279186 20260105130716.0 pmid:40800978 pmid 10.1162/imag_a_00453 doi altmetric:173235689 altmetric pmc:PMC12319795 pmc DZNE-2025-00714 610 Chai, Yuhui 0 Blood nulling versus tissue suppression: Enhancing integrated VASO and perfusion (VAPER) contrast for laminar fMRI Cambridge, MA 2025 MIT Press article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1751967400_3176 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Cerebral blood volume (CBV) and cerebral blood flow (CBF)-based functional magnetic resonance imaging (fMRI) have proven to be more laminar-specific than blood-oxygen-level-dependent (BOLD) contrast fMRI, but they suffer from relatively low sensitivity. In previous work, we integrated CBV and CBF into one contrast using DANTE (Delay Alternating with Nutation for Tailored Excitation) pulse trains combined with 3D echo-planar imaging (EPI) to create an integrated blood volume and perfusion (VAPER)-weighted contrast (Chai et al., 2020). Building on this, we have now introduced a magnetization transfer approach to induce a tissue-suppression-based VASO (vascular space occupancy) effect and incorporated it with the VAPER technique to boost the overall sensitivity while maintaining superior laminar specificity, all without altering the original VAPER sequence timing scheme. This magnetization transfer (MT)-VAPER fMRI acquisition alternates between DANTE blood-nulling and MT-tissue-suppression conditions, generating an integrated VASO and perfusion contrast enhanced by MT. Both theoretical and experimental evaluation demonstrated an approximately 30% enhancement in VAPER sensitivity with MT application. This novel MT-VAPER method was empirically validated in human primary motor and visual cortices, demonstrating its superior laminar specificity and robust reproducibility, establishing it as valuable non-BOLD tool for laminar fMRI in human brain function research. 354 - Disease Prevention and Healthy Aging (POF4-354) G:(DE-HGF)POF4-354 POF4-354 POF IV 0 Dataset connected to CrossRef, Journals: pub.dzne.de Li, Linqing 1 Stirnberg, Rüdiger P:(DE-2719)2810697 2 dzne Huber, Laurentius 3 Stöcker, Tony P:(DE-2719)2810538 4 dzne Bandettini, Peter A. 5 Sutton, Bradley P. 6 10.1162/imag_a_00453 Vol. 3, p. imag_a_00453 PERI:(DE-600)3167925-0 imag_a_00453 Imaging neuroscience 3 2025 2837-6056 http://pub.dzne.de/record/279186/files/DZNE-2025-00714%20SUP.pdf OpenAccess http://pub.dzne.de/record/279186/files/DZNE-2025-00714.pdf pdfa http://pub.dzne.de/record/279186/files/DZNE-2025-00714%20SUP.pdf?subformat=pdfa OpenAccess pdfa http://pub.dzne.de/record/279186/files/DZNE-2025-00714.pdf?subformat=pdfa oai:pub.dzne.de:279186 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2810697 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2810538 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-354 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Prevention and Healthy Aging 0 2025 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2024-09-26T09:40:26Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2024-09-26T09:40:26Z OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Anonymous peer review 2024-09-26T09:40:26Z Article Processing Charges StatID:(DE-HGF)0561 StatID 2025-01-02 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-01-02 Fees StatID:(DE-HGF)0700 StatID 2025-01-02 I:(DE-2719)1013026 AG Stöcker MR Physics 0 journal VDB UNRESTRICTED I:(DE-2719)1013026 FullTexts