280047 20260105130744.0 pmc:PMC12279471 pmc 10.1002/alz.70482 doi pmid:40691867 pmid 1552-5260 ISSN 1552-5279 ISSN altmetric:179651630 altmetric DZNE-2025-00886 English 610 Baumeister, Hannah P:(DE-2719)9001499 0 First author dzne Disease stage-specific atrophy markers in Alzheimer's disease. Hoboken, NJ 2025 Wiley article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1755687043_25773 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Structural magnetic resonance imaging (MRI) often lacks diagnostic, prognostic, and monitoring value in Alzheimer's disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal atrophy markers for different intended uses.We included 363 older adults; cognitively unimpaired individuals who were negative or positive for amyloid beta (Aβ) and Aβ-positive patients with subjective cognitive decline, mild cognitive impairment, or dementia of the Alzheimer type. MRI and neuropsychological assessments were administered annually for up to 3 years.Accelerated atrophy of medial temporal lobe subregions was evident already during preclinical AD. Symptomatic disease stages most notably differed in their hippocampal and parietal atrophy signatures. Atrophy-cognition relationships varied by intended use and disease stage.With the appropriate marker, MRI can detect abnormal atrophy already during preclinical AD. To optimize performance, atrophy markers should be tailored to the targeted disease stage and intended use.Subregional atrophy markers detect ongoing atrophy in preclinical Alzheimer's disease (AD). Subjective cognitive decline in preclinical AD links to manifest atrophy. Optimal atrophy markers differ by the disease stage and intended use. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 352 - Disease Mechanisms (POF4-352) G:(DE-HGF)POF4-352 POF4-352 POF IV 1 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de imaging biomarker Other longitudinal atrophy Other magnetic resonance imaging Other medial temporal lobe Other parietal lobe Other Biomarkers NLM Chemicals Amyloid beta-Peptides NLM Chemicals Humans MeSH Alzheimer Disease: pathology MeSH Alzheimer Disease: diagnostic imaging MeSH Atrophy: pathology MeSH Magnetic Resonance Imaging MeSH Male MeSH Female MeSH Aged MeSH Cognitive Dysfunction: pathology MeSH Cognitive Dysfunction: diagnostic imaging MeSH Neuropsychological Tests MeSH Biomarkers MeSH Amyloid beta-Peptides MeSH Brain: pathology MeSH Brain: diagnostic imaging MeSH Disease Progression MeSH Aged, 80 and over MeSH Hippocampus: pathology MeSH EXP:(DE-2719)DELCODE-20140101 EXP:(DE-2719)DELCODE-20140101 Longitudinal Cognitive Impairment and Dementia Study 0 Gellersen, Helena M P:(DE-2719)9002125 1 dzne Polk, Sarah E P:(DE-2719)9002772 2 dzne Lattmann, René P:(DE-2719)9001995 3 dzne Wuestefeld, Anika 4 Wisse, Laura E M 5 Glenn, Trevor 6 Yakupov, Renat P:(DE-2719)2812398 7 dzne Stark, Melina P:(DE-2719)9001773 8 dzne Kleineidam, Luca P:(DE-2719)2812139 9 dzne Roeske, Sandra P:(DE-2719)2810395 10 dzne Marcos Morgado, Barbara P:(DE-2719)9003591 11 dzne Esselmann, Hermann 12 Brosseron, Frederic P:(DE-2719)2810593 13 dzne Ramirez, Alfredo P:(DE-2719)2812825 14 dzne Lüsebrink, Falk P:(DE-2719)9002520 15 dzne Synofzik, Matthis P:(DE-2719)2811275 16 dzne Schott, Björn H P:(DE-2719)2814326 17 dzne Schmid, Matthias C P:(DE-2719)2811245 18 dzne Hetzer, Stefan 19 Dechent, Peter 20 Scheffler, Klaus 21 Ewers, Michael P:(DE-2719)9000543 22 Hellmann-Regen, Julian P:(DE-2719)9003016 23 dzne Ersözlü, Ersin P:(DE-2719)9002917 24 dzne Spruth, Eike Jakob P:(DE-2719)2812446 25 Gemenetzi, Maria P:(DE-2719)9002025 26 dzne Fliessbach, Klaus P:(DE-2719)2811326 27 dzne Bartels, Claudia 28 Rostamzadeh, Ayda 29 Glanz, Wenzel P:(DE-2719)2811614 30 dzne Incesoy, Enise I P:(DE-2719)9001517 31 dzne Janowitz, Daniel P:(DE-2719)9002557 32 dzne Rauchmann, Boris Stephan P:(DE-2719)9001808 33 dzne Kilimann, Ingo P:(DE-2719)2810394 34 dzne Sodenkamp, Sebastian P:(DE-2719)9003152 35 dzne Coenjaerts, Marie P:(DE-HGF)0 36 Spottke, Annika P:(DE-2719)2811324 37 dzne Peters, Oliver P:(DE-2719)2811024 38 dzne Priller, Josef P:(DE-2719)2811122 39 dzne Schneider, Anja P:(DE-2719)2812035 40 dzne Wiltfang, Jens P:(DE-2719)2811317 41 dzne Buerger, Katharina P:(DE-2719)2811351 42 dzne Perneczky, Robert P:(DE-2719)2812234 43 dzne Teipel, Stefan P:(DE-2719)2000026 44 dzne Laske, Christoph P:(DE-2719)2000055 45 dzne Wagner, Michael P:(DE-2719)2000057 46 dzne Ziegler, Gabriel P:(DE-2719)2814076 47 dzne Jessen, Frank P:(DE-2719)2000032 48 dzne Düzel, Emrah P:(DE-2719)2000005 49 dzne Berron, David P:(DE-2719)2812972 50 Last author dzne group, DELCODE study 51 Collaboration Author 10.1002/alz.70482 Vol. 21, no. 7, p. e70482 PERI:(DE-600)2201940-6 7 e70482 Alzheimer's and dementia 21 2025 1552-5260 http://pub.dzne.de/record/280047/files/DZNE-2025-00886%20SUP1.docx http://pub.dzne.de/record/280047/files/DZNE-2025-00886%20SUP2.pdf OpenAccess http://pub.dzne.de/record/280047/files/DZNE-2025-00886.pdf pdfa http://pub.dzne.de/record/280047/files/DZNE-2025-00886%20SUP2.pdf?subformat=pdfa OpenAccess pdfa http://pub.dzne.de/record/280047/files/DZNE-2025-00886.pdf?subformat=pdfa oai:pub.dzne.de:280047 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9001499 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)9002125 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)9002772 Deutsches Zentrum für Neurodegenerative 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G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-352 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Mechanisms 1 2025 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2025-01-06 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2025-01-06 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC JCR StatID:(DE-HGF)0100 StatID ALZHEIMERS DEMENT : 2022 2025-01-06 DEAL Wiley StatID:(DE-HGF)3001 StatID 2025-01-06 ger WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2025-01-06 IF >= 10 StatID:(DE-HGF)9910 StatID ALZHEIMERS DEMENT : 2022 2025-01-06 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2025-01-06 OpenAccess StatID:(DE-HGF)0510 StatID DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-01-06 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2025-01-06 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2025-01-06 I:(DE-2719)5000070 AG Berron Clinical Cognitive Neuroscience 0 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