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@ARTICLE{vonZedtwitz:281644,
      author       = {von Zedtwitz, Katharina and Tebartz van Elst, Ludger and
                      Feige, Bernd and Matteit, Isabelle and Schlump, Andrea and
                      Lange, Thomas and Runge, Kimon and Nickel, Kathrin and
                      Venhoff, Nils and Domschke, Katharina and Prüss, Harald and
                      Rau, Alexander and Reisert, Marco and Maier, Simon J and
                      Endres, Dominique},
      title        = {{M}orphometric {MRI} findings in patients with suspected
                      autoimmune psychosis spectrum syndromes and association with
                      {EEG} slowing, {CSF} changes, and
                      psychometric/neuropsychological findings.},
      journal      = {Frontiers in immunology},
      volume       = {16},
      issn         = {1664-3224},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DZNE-2025-01162},
      pages        = {1648946},
      year         = {2025},
      abstract     = {Patients with autoimmune encephalitis - who often have
                      accompanying psychiatric symptoms - frequently have
                      electroencephalography (EEG) changes and normal conventional
                      magnetic resonance imaging (MRI) findings. The aim of this
                      paper was to analyze automated EEG and morphometric MRI
                      findings in psychiatric patients with suspected autoimmune
                      psychosis (AP) spectrum syndromes versus controls and the
                      correlation of MRI measures with EEG, cerebrospinal fluid
                      (CSF), and psychometric/neuropsychological findings.In
                      total, forty patients were included. Suspected AP spectrum
                      syndromes were defined broadly based on the autoimmune
                      psychiatric syndrome concept. All patients showed signs of
                      an autoimmune process. That is, upon further diagnostic
                      testing, they tested at least positive for
                      well-characterized neuronal antibodies, novel central
                      nervous system antibodies, or well-characterized systemic
                      antibodies with brain involvement. For EEG, thirty-seven
                      matched patient-control pairs, and for structural MRI,
                      thirty-five patients and matched controls, were available.
                      EEG analysis for intermittent rhythmic delta/theta activity
                      (IRDA/IRTA) was performed using independent component
                      analysis. MRI scans were analyzed using FreeSurfer (7.2) for
                      the subcortical measures and CAT12 for cortical thickness
                      and global volumes.Patients did not show significantly
                      increased IRDA/IRTA rates. Regarding brain volumes, there
                      was a significant decrease in grey matter volume/total
                      intracranial volume (TIV) (p=0.027) and a significant
                      increase in CSF/TIV (p=0.027), which remained significant
                      after correction for multiple comparisons. Further
                      differences with lower white matter volume/TIV, reduced
                      cortical thickness in the left parahippocampal and
                      transversotemporal gyri and an increase in the volume of the
                      left lateral ventricle of patients did not remain
                      significant after correcting for multiple testing. White
                      blood cell counts in the CSF of the whole patient group
                      correlated positively with increased hippocampal volumes.
                      Brain volumes did not correlate with psychometric scales,
                      but with several neuropsychological
                      scores.Autoantibody-associated suspected AP spectrum
                      syndromes seem to be associated with slight global grey
                      matter volume reductions and secondary increased CSF
                      volumes. Associations between hippocampal volume increases
                      and inflammatory CSF markers could, in contrast, reflect
                      edematous swelling within the limbic system. Further
                      multimodal imaging studies of more homogeneous AP groups
                      might be promising to detect morphometric correlates.},
      keywords     = {Humans / Female / Male / Electroencephalography / Magnetic
                      Resonance Imaging / Adult / Psychotic Disorders: diagnostic
                      imaging / Psychotic Disorders: physiopathology / Psychotic
                      Disorders: psychology / Psychotic Disorders: diagnosis /
                      Psychotic Disorders: immunology / Middle Aged /
                      Psychometrics / Brain: diagnostic imaging / Brain:
                      physiopathology / Neuropsychological Tests / Young Adult /
                      autoantibody (Other) / brain (Other) / cortical thickness
                      (Other) / neuroinflammation (Other) / structural MRI
                      (Other)},
      cin          = {AG Prüß},
      ddc          = {610},
      cid          = {I:(DE-2719)1810003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41064005},
      pmc          = {pmc:PMC12500446},
      doi          = {10.3389/fimmu.2025.1648946},
      url          = {https://pub.dzne.de/record/281644},
}