281820 20260105141703.0 pmc:PMC12559990 pmc 10.1113/JP286400 doi pmid:39367860 pmid 0022-3751 ISSN 1469-7793 ISSN DZNE-2025-01201 English 610 Reshetniak, Sofiia 0000-0003-4847-4144 0 The synaptic vesicle cluster as a controller of pre- and postsynaptic structure and function. Hoboken, NJ 2025 Wiley-Blackwell article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1763031559_32671 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter-loaded vesicles during synaptic activity, at the same time as also controlling the local concentrations of numerous exo- and endocytosis cofactors. In addition, the SVC hosts molecules that participate in other aspects of synaptic function, from cytoskeletal components to adhesion proteins, and affects the location and function of organelles such as mitochondria and the endoplasmic reticulum. We argue here that these features extend the functional involvement of the SVC in synapse formation, signalling and plasticity, as well as synapse stabilization and metabolism. We also propose that changes in the size of the SVC coalesce with changes in the postsynaptic compartment, supporting the interplay between pre- and postsynaptic dynamics. Thereby, the SVC could be seen as an 'all-in-one' regulator of synaptic structure and function, which should be investigated in more detail, to reveal molecular mechanisms that control synaptic function and heterogeneity. 352 - Disease Mechanisms (POF4-352) G:(DE-HGF)POF4-352 POF4-352 POF IV 0 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 1 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de synapse Other synapse formation Other synaptic plasticity Other synaptic vesicle cluster Other vesicle Other Synaptic Vesicles: physiology MeSH Animals MeSH Humans MeSH Synapses: physiology MeSH Synaptic Transmission: physiology MeSH Presynaptic Terminals: physiology MeSH Bogaciu, Cristian A 0009-0004-7781-7040 1 Bonn, Stefan P:(DE-2719)2810547 2 Brose, Nils 3 Cooper, Benjamin H 4 D'Este, Elisa 5 Fauth, Michael 6 Fernández-Busnadiego, Rubén 0000-0002-8366-7622 7 Fiosins, Maksims 8 Fischer, André P:(DE-2719)2000047 9 Georgiev, Svilen V 10 Jakobs, Stefan 11 Klumpp, Stefan 0000-0003-0584-2146 12 Köster, Sarah 13 Lange, Felix 0000-0003-1135-0797 14 Lipstein, Noa 0000-0002-0755-5899 15 Macarrón-Palacios, Victor 0000-0001-7788-4914 16 Milovanovic, Dragomir P:(DE-2719)9000670 17 Moser, Tobias 0000-0001-7145-0533 18 Müller, Marcus 0000-0002-7472-973X 19 Opazo, Felipe 0000-0002-4968-9713 20 Outeiro, Tiago P:(DE-2719)2814138 21 dzne Pape, Constantin 22 Priesemann, Viola 23 Rehling, Peter 0000-0001-5661-5272 24 Salditt, Tim 25 Schlüter, Oliver 26 Simeth, Nadja 0000-0001-8130-883X 27 Steinem, Claudia 28 Tchumatchenko, Tatjana 29 Tetzlaff, Christian 30 Tirard, Marilyn 0000-0002-5669-9610 31 Urlaub, Henning 32 Wichmann, Carolin 33 Wolf, Fred 34 Rizzoli, Silvio O 0000-0002-1667-7839 35 The giant impact of synapses on brain function and disease 10.1113/JP286400 Vol. 603, no. 20, p. 5935 - 5964 PERI:(DE-600)1475290-6 20 5935 - 5964 The journal of physiology 603 2025 0022-3751 http://pub.dzne.de/record/281820/files/DZNE-2025-01201%20SUP.pdf OpenAccess http://pub.dzne.de/record/281820/files/DZNE-2025-01201.pdf pdfa http://pub.dzne.de/record/281820/files/DZNE-2025-01201%20SUP.pdf?subformat=pdfa OpenAccess pdfa http://pub.dzne.de/record/281820/files/DZNE-2025-01201.pdf?subformat=pdfa oai:pub.dzne.de:281820 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 9 P:(DE-2719)2000047 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 17 P:(DE-2719)9000670 External Institute I:(DE-HGF)0 Extern 21 P:(DE-2719)2814138 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-352 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Mechanisms 0 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 1 2025 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2025-01-02 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-01-02 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2025-01-02 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2025-01-02 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2025-01-02 JCR StatID:(DE-HGF)0100 StatID J PHYSIOL-LONDON : 2022 2025-01-02 DEAL Wiley StatID:(DE-HGF)3001 StatID 2025-01-02 ger DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2025-01-02 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2025-01-02 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2025-01-02 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2025-01-02 IF >= 5 StatID:(DE-HGF)9905 StatID J PHYSIOL-LONDON : 2022 2025-01-02 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2025-01-02 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2025-01-02 I:(DE-2719)1410002 AG Fischer Epigenetics and Systems Medicine in Neurodegenerative Diseases 0 I:(DE-2719)1813002 AG Milovanovic (Berlin) Molecular Neuroscience 1 journal VDB UNRESTRICTED I:(DE-2719)1410002 I:(DE-2719)1813002 FullTexts