281857 20251118102958.0 10.1177/13872877251331222 doi pmid:40255031 pmid pmc:PMC12583655 pmc 1387-2877 ISSN 1875-8908 ISSN DZNE-2025-01230 English 610 Singh, Devesh P:(DE-2719)9002353 0 First author A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans. Amsterdam 2025 IOS Press article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1763374569_17169 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote BackgroundConvolutional neural network (CNN) based volumetry of MRI data can help differentiate Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD) as causes of cognitive decline and dementia. However, existing CNN-based MRI volumetry tools lack a structured hierarchical representation of brain anatomy, which would allow for aggregating regional pathological information and automated computational inference.ObjectiveDevelop a computational ontology pipeline for quantifying hierarchical pathological abnormalities and visualize summary charts for brain atrophy findings, aiding differential diagnosis.MethodsUsing FastSurfer, we segmented brain regions and measured volume and cortical thickness from MRI scans pooled across multiple cohorts (N = 3433; ADNI, AIBL, DELCODE, DESCRIBE, EDSD, and NIFD), including healthy controls, prodromal and clinical AD cases, and bvFTD cases. Employing the Web Ontology Language (OWL), we built a semantic model encoding hierarchical anatomical information. Additionally, we created summary visualizations based on sunburst plots for visual inspection of the information stored in the ontology.ResultsOur computational framework dynamically estimated and aggregated regional pathological deviations across different levels of neuroanatomy abstraction. The disease similarity index derived from the volumetric and cortical thickness deviations achieved an AUC of 0.88 for separating AD and bvFTD, which was also reflected by distinct atrophy profile visualizations.ConclusionsThe proposed automated pipeline facilitates visual comparison of atrophy profiles across various disease types and stages. It provides a generalizable computational framework for summarizing pathologic findings, potentially enhancing the physicians' ability to evaluate brain pathologies robustly and interpretably. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Alzheimer's disease Other brain volumetry Other computer graphics Other frontotemporal dementia Other magnetic resonance imaging Other neuroanatomy Other ontology Other Humans MeSH Magnetic Resonance Imaging: methods MeSH Alzheimer Disease: pathology MeSH Alzheimer Disease: diagnostic imaging MeSH Brain: pathology MeSH Brain: diagnostic imaging MeSH Male MeSH Female MeSH Aged MeSH Frontotemporal Dementia: pathology MeSH Frontotemporal Dementia: diagnostic imaging MeSH Atrophy: pathology MeSH Neural Networks, Computer MeSH Middle Aged MeSH Grazia, Alice P:(DE-2719)9001307 1 Reiz, Achim 0000-0003-1446-9670 2 Hermann, Andreas P:(DE-2719)2811732 3 Altenstein, Slawek P:(DE-2719)2811720 4 Beichert, Lukas 0009-0000-9259-9230 5 Bernhardt, Alexander P:(DE-2719)9002620 6 Buerger, Katharina P:(DE-2719)2811351 7 dzne Butryn, Michaela P:(DE-2719)9001011 8 dzne Dechent, Peter 0009-0006-4005-3352 9 Duezel, Emrah P:(DE-2719)2000005 10 dzne Ewers, Michael P:(DE-2719)9000543 11 Fliessbach, Klaus P:(DE-2719)2811326 12 dzne Freiesleben, Silka D P:(DE-2719)2812392 13 Glanz, Wenzel P:(DE-2719)2811614 14 Hetzer, Stefan 0000-0002-1773-1518 15 Janowitz, Daniel P:(DE-2719)9002557 16 dzne Kilimann, Ingo P:(DE-2719)2810394 17 Kimmich, Okka P:(DE-2719)9002382 18 dzne Laske, Christoph P:(DE-2719)2000055 19 dzne Levin, Johannes P:(DE-2719)2811659 20 Lohse, Andrea P:(DE-2719)2811189 21 Lüsebrink-Rindsland, Jann Falk Silvester P:(DE-2719)9002520 22 dzne Munk, Matthias P:(DE-2719)9001516 23 Perneczky, Robert P:(DE-2719)2812234 24 Peters, Oliver P:(DE-2719)2811024 25 Preis, Lukas P:(DE-2719)9000703 26 dzne Priller, Josef P:(DE-2719)2811122 27 Prudlo, Johannes P:(DE-2719)2380559 28 dzne Rauchmann, Boris Stephan P:(DE-2719)9001808 29 dzne Rostamzadeh, Ayda 0000-0001-5189-134X 30 Roy-Kluth, Nina P:(DE-2719)2812341 31 dzne Scheffler, Klaus 0000-0001-6316-8773 32 Schneider, Anja P:(DE-2719)2812035 33 dzne Schneider, Luisa-Sophie P:(DE-2719)9002878 34 dzne Schott, Björn H P:(DE-2719)2814326 35 Spottke, Annika P:(DE-2719)2811324 36 dzne Spruth, Eike Jakob P:(DE-2719)2812446 37 dzne Synofzik, Matthis P:(DE-2719)2811275 38 Wiltfang, Jens P:(DE-2719)2811317 39 Jessen, Frank P:(DE-2719)2000032 40 dzne Teipel, Stefan J P:(DE-2719)2000026 41 Dyrba, Martin P:(DE-2719)2810283 42 Last author ADNI 43 Collaboration Author AIBL 44 Collaboration Author FTLDNI 45 Collaboration Author groups, study 46 Collaboration Author 10.1177/13872877251331222 Vol. 108, no. 1_suppl PERI:(DE-600)2070772-1 1_suppl S258 - S273 Journal of Alzheimer's disease 108 2025 1387-2877 http://pub.dzne.de/record/281857/files/DZNE-2025-01230%20SUP.docx OpenAccess http://pub.dzne.de/record/281857/files/DZNE-2025-01230.pdf http://pub.dzne.de/record/281857/files/DZNE-2025-01230%20SUP.doc http://pub.dzne.de/record/281857/files/DZNE-2025-01230%20SUP.odt http://pub.dzne.de/record/281857/files/DZNE-2025-01230%20SUP.pdf OpenAccess pdfa http://pub.dzne.de/record/281857/files/DZNE-2025-01230.pdf?subformat=pdfa oai:pub.dzne.de:281857 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9002353 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)9001307 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2811732 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2811720 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)9002620 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)2811351 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 8 P:(DE-2719)9001011 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 10 P:(DE-2719)2000005 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 11 P:(DE-2719)9000543 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 12 P:(DE-2719)2811326 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 13 P:(DE-2719)2812392 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 14 P:(DE-2719)2811614 External Institute I:(DE-HGF)0 Extern 16 P:(DE-2719)9002557 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 17 P:(DE-2719)2810394 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 18 P:(DE-2719)9002382 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 19 P:(DE-2719)2000055 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 20 P:(DE-2719)2811659 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 22 P:(DE-2719)9002520 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 23 P:(DE-2719)9001516 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 24 P:(DE-2719)2812234 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 25 P:(DE-2719)2811024 External Institute I:(DE-HGF)0 Extern 26 P:(DE-2719)9000703 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 27 P:(DE-2719)2811122 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 28 P:(DE-2719)2380559 External Institute I:(DE-HGF)0 Extern 29 P:(DE-2719)9001808 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 31 P:(DE-2719)2812341 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 33 P:(DE-2719)2812035 External Institute I:(DE-HGF)0 Extern 34 P:(DE-2719)9002878 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 35 P:(DE-2719)2814326 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 36 P:(DE-2719)2811324 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 37 P:(DE-2719)2812446 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 38 P:(DE-2719)2811275 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 39 P:(DE-2719)2811317 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 40 P:(DE-2719)2000032 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 41 P:(DE-2719)2000026 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 42 P:(DE-2719)2810283 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2025 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2024-12-20 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2024-12-20 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2024-12-20 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2024-12-20 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2024-12-20 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2024-12-20 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2024-12-20 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2024-12-20 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2024-12-20 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2024-12-20 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2024-12-20 I:(DE-2719)1510100 AG Teipel Clinical Dementia Research (Rostock /Greifswald) 0 I:(DE-2719)1011103 AG Spottke Clinical Research Platform (CRP) 1 I:(DE-2719)1011401 Clinical Research Platform (CRP) Clinical Research Platform (CRP) 2 I:(DE-2719)1511100 AG Hermann Translational Neurodegeneration 3 I:(DE-2719)5000007 AG Priller Translational Neuropsychiatry 4 I:(DE-2719)1111015 Clinical Research (Munich) Clinical Research (Munich) 5 I:(DE-2719)5000006 AG Düzel Clinical Neurophysiology and Memory 6 I:(DE-2719)1011101 Patient Studies (Bonn) Patient Studies (Bonn) 7 I:(DE-2719)5000000 AG Peters Biomarker-Assisted Early Detection of Dementias 8 I:(DE-2719)1011001 Clinical Research (Bonn) Clinical Research Coordination 9 I:(DE-2719)1210000 AG Gasser Parkinson Genetics 10 I:(DE-2719)1111016 AG Levin Clinical Neurodegeneration 11 I:(DE-2719)5000022 AG Dichgans Vascular Cognitive Impairment & Post-Stroke Dementia 12 I:(DE-2719)1011305 AG Schneider Translational Dementia Research (Bonn) 13 I:(DE-2719)1011102 AG Jessen Clinical Alzheimer’s Disease Research 14 I:(DE-2719)1410006 AG Wiltfang Molecular biomarkers for predictive diagnostics of neurodegenerative diseases 15 journal VDB UNRESTRICTED I:(DE-2719)1510100 I:(DE-2719)1011103 I:(DE-2719)1011401 I:(DE-2719)1511100 I:(DE-2719)5000007 I:(DE-2719)1111015 I:(DE-2719)5000006 I:(DE-2719)1011101 I:(DE-2719)5000000 I:(DE-2719)1011001 I:(DE-2719)1210000 I:(DE-2719)1111016 I:(DE-2719)5000022 I:(DE-2719)1011305 I:(DE-2719)1011102 I:(DE-2719)1410006 FullTexts