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000281876 0247_ $$2ISSN$$a0065-1591
000281876 0247_ $$2ISSN$$a1600-0447
000281876 0247_ $$2ISSN$$a1600-5473
000281876 037__ $$aDZNE-2025-01247
000281876 041__ $$aEnglish
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000281876 1001_ $$aSolé, B.$$b0
000281876 245__ $$aUnravelling the Link Between Body Mass Index and Cognitive Performance in Individuals With Bipolar Disorder and Exploration of PRS Moderation Effect: Findings From the PsyCourse Study.
000281876 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2025
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000281876 520__ $$aBipolar disorder (BD) is a severe mental disorder characterized by extreme mood swings, often accompanied by metabolic comorbidities, such as cardiovascular disease, which increase mortality and reduce quality of life. Both metabolic dysfunctions and BD are associated with cognitive dysfunction. Body mass index (BMI) is closely linked to metabolic health and cognitive performance. This study examined the link between BMI and cognitive function in individuals with BD and how genetic factors, namely polygenic risk scores (PRS) for BD and BMI, might influence this link.Genetic (PRS scores) and phenotypic data (sociodemographic factors, clinical symptoms and cognitive function) of 341 adult patients with BD diagnosis from the PsyCourse Study, a large, multi-site, and naturalistic longitudinal study, were utilized for this study. First, we performed univariate and multivariate regression analyses to investigate associations between BMI and cognitive performance. Second, moderation analyses were conducted to examine the potential moderator effects of BD-PRS or BMI-PRS in the relationship between BMI and different cognitive outcomes.BMI was associated with processing speed (TMT-A) and executive function (TMT-B), with individuals with higher BMI showing poorer performance. Moderation analyses revealed that the effect of BMI on cognition was moderated by BD-PRS only regarding the processing speed. BMI-PRS did not moderate the association between BMI and cognitive variables.Our findings indicate that the relationship between BMI and cognitive impairment in BD is partially moderated by BD genetic liability but not by BMI genetic load.
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000281876 650_7 $$2Other$$abipolar disorder
000281876 650_7 $$2Other$$abody mass index
000281876 650_7 $$2Other$$aexecutive function
000281876 650_7 $$2Other$$apolygenic risk scores (PRS)
000281876 650_7 $$2Other$$apsychomotor speed
000281876 650_2 $$2MeSH$$aHumans
000281876 650_2 $$2MeSH$$aBipolar Disorder: genetics
000281876 650_2 $$2MeSH$$aBipolar Disorder: physiopathology
000281876 650_2 $$2MeSH$$aBipolar Disorder: complications
000281876 650_2 $$2MeSH$$aMale
000281876 650_2 $$2MeSH$$aFemale
000281876 650_2 $$2MeSH$$aBody Mass Index
000281876 650_2 $$2MeSH$$aAdult
000281876 650_2 $$2MeSH$$aMiddle Aged
000281876 650_2 $$2MeSH$$aCognitive Dysfunction: physiopathology
000281876 650_2 $$2MeSH$$aCognitive Dysfunction: etiology
000281876 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000281876 650_2 $$2MeSH$$aLongitudinal Studies
000281876 650_2 $$2MeSH$$aExecutive Function: physiology
000281876 650_2 $$2MeSH$$aMultifactorial Inheritance
000281876 7001_ $$aMontejo, L.$$b1
000281876 7001_ $$aBudde, M.$$b2
000281876 7001_ $$aValentí, M.$$b3
000281876 7001_ $$aBorràs, R.$$b4
000281876 7001_ $$aMartín-Parra, S.$$b5
000281876 7001_ $$aRuiz, A.$$b6
000281876 7001_ $$aMartínez-Aran, A.$$b7
000281876 7001_ $$aAdorjan, K.$$b8
000281876 7001_ $$aHeilbronner, M.$$b9
000281876 7001_ $$aNavarro-Flores, A.$$b10
000281876 7001_ $$aOraki Kohshour, M.$$b11
000281876 7001_ $$aReich-Erkelenz, D.$$b12
000281876 7001_ $$0P:(DE-HGF)0$$aSchulte, E. C.$$b13
000281876 7001_ $$aSenner, F.$$b14
000281876 7001_ $$aAnghelescu, I. G.$$b15
000281876 7001_ $$aArolt, V.$$b16
000281876 7001_ $$aBaune, B. T.$$b17
000281876 7001_ $$aDannlowski, U.$$b18
000281876 7001_ $$aDietrich, D. E.$$b19
000281876 7001_ $$0P:(DE-HGF)0$$aFallgatter, A. J.$$b20
000281876 7001_ $$aFigge, C.$$b21
000281876 7001_ $$00000-0001-9860-9620$$aJuckel, G.$$b22
000281876 7001_ $$0P:(DE-HGF)0$$aKonrad, C.$$b23
000281876 7001_ $$aReimer, J.$$b24
000281876 7001_ $$aReininghaus, E. Z.$$b25
000281876 7001_ $$aSchmauß, M.$$b26
000281876 7001_ $$aSpitzer, C.$$b27
000281876 7001_ $$0P:(DE-2719)2811317$$aWiltfang, J.$$b28$$udzne
000281876 7001_ $$aZimmermann, J.$$b29
000281876 7001_ $$aFalkai, P.$$b30
000281876 7001_ $$00000-0002-0548-0053$$aVieta, E.$$b31
000281876 7001_ $$0P:(DE-HGF)0$$aSchulze, T. G.$$b32
000281876 7001_ $$0P:(DE-HGF)0$$aTorrent, C.$$b33
000281876 7001_ $$aHeilbronner, U.$$b34
000281876 7001_ $$aPapiol, S.$$b35
000281876 773__ $$0PERI:(DE-600)2005703-9$$a10.1111/acps.70028$$gVol. 152, no. 6, p. 451 - 461$$n6$$p451 - 461$$tActa psychiatrica Scandinavica$$v152$$x0001-690X$$y2025
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