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@ARTICLE{Sol:281876,
      author       = {Solé, B. and Montejo, L. and Budde, M. and Valentí, M.
                      and Borràs, R. and Martín-Parra, S. and Ruiz, A. and
                      Martínez-Aran, A. and Adorjan, K. and Heilbronner, M. and
                      Navarro-Flores, A. and Oraki Kohshour, M. and
                      Reich-Erkelenz, D. and Schulte, E. C. and Senner, F. and
                      Anghelescu, I. G. and Arolt, V. and Baune, B. T. and
                      Dannlowski, U. and Dietrich, D. E. and Fallgatter, A. J. and
                      Figge, C. and Juckel, G. and Konrad, C. and Reimer, J. and
                      Reininghaus, E. Z. and Schmauß, M. and Spitzer, C. and
                      Wiltfang, J. and Zimmermann, J. and Falkai, P. and Vieta, E.
                      and Schulze, T. G. and Torrent, C. and Heilbronner, U. and
                      Papiol, S.},
      title        = {{U}nravelling the {L}ink {B}etween {B}ody {M}ass {I}ndex
                      and {C}ognitive {P}erformance in {I}ndividuals {W}ith
                      {B}ipolar {D}isorder and {E}xploration of {PRS} {M}oderation
                      {E}ffect: {F}indings {F}rom the {P}sy{C}ourse {S}tudy.},
      journal      = {Acta psychiatrica Scandinavica},
      volume       = {152},
      number       = {6},
      issn         = {0001-690X},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-01247},
      pages        = {451 - 461},
      year         = {2025},
      abstract     = {Bipolar disorder (BD) is a severe mental disorder
                      characterized by extreme mood swings, often accompanied by
                      metabolic comorbidities, such as cardiovascular disease,
                      which increase mortality and reduce quality of life. Both
                      metabolic dysfunctions and BD are associated with cognitive
                      dysfunction. Body mass index (BMI) is closely linked to
                      metabolic health and cognitive performance. This study
                      examined the link between BMI and cognitive function in
                      individuals with BD and how genetic factors, namely
                      polygenic risk scores (PRS) for BD and BMI, might influence
                      this link.Genetic (PRS scores) and phenotypic data
                      (sociodemographic factors, clinical symptoms and cognitive
                      function) of 341 adult patients with BD diagnosis from the
                      PsyCourse Study, a large, multi-site, and naturalistic
                      longitudinal study, were utilized for this study. First, we
                      performed univariate and multivariate regression analyses to
                      investigate associations between BMI and cognitive
                      performance. Second, moderation analyses were conducted to
                      examine the potential moderator effects of BD-PRS or BMI-PRS
                      in the relationship between BMI and different cognitive
                      outcomes.BMI was associated with processing speed (TMT-A)
                      and executive function (TMT-B), with individuals with higher
                      BMI showing poorer performance. Moderation analyses revealed
                      that the effect of BMI on cognition was moderated by BD-PRS
                      only regarding the processing speed. BMI-PRS did not
                      moderate the association between BMI and cognitive
                      variables.Our findings indicate that the relationship
                      between BMI and cognitive impairment in BD is partially
                      moderated by BD genetic liability but not by BMI genetic
                      load.},
      keywords     = {Humans / Bipolar Disorder: genetics / Bipolar Disorder:
                      physiopathology / Bipolar Disorder: complications / Male /
                      Female / Body Mass Index / Adult / Middle Aged / Cognitive
                      Dysfunction: physiopathology / Cognitive Dysfunction:
                      etiology / Cognitive Dysfunction: genetics / Longitudinal
                      Studies / Executive Function: physiology / Multifactorial
                      Inheritance / bipolar disorder (Other) / body mass index
                      (Other) / executive function (Other) / polygenic risk scores
                      (PRS) (Other) / psychomotor speed (Other)},
      cin          = {AG Wiltfang},
      ddc          = {610},
      cid          = {I:(DE-2719)1410006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40887816},
      doi          = {10.1111/acps.70028},
      url          = {https://pub.dzne.de/record/281876},
}