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000281880 041__ $$aEnglish
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000281880 1001_ $$aSchwarzer, Johannes$$b0
000281880 245__ $$aComparison of brain volumetry in patients with non-lesional epilepsy on 3 and 7 T MPRAGE.
000281880 260__ $$aHong Kong$$bAME Publ.$$c2025
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000281880 520__ $$a7 Tesla (T) magnetic resonance imaging (MRI) provides more accurate image resolution than 3 T MRI due to its higher field strength. This could lead to a significant improvement in diagnostics, especially in small anatomical regions like the substructures of the hippocampus and amygdala. However, inhomogeneities arise due to higher field strengths, which could reduce this benefit. We compared current segmentations between 3 and 7 T in a clinical setup. The aim of this study was to evaluate the feasibility of FreeSurfer and FastSurfer at 7 T MRI in comparison to 3 T MRI. Since the hippocampus and amygdala also play an important role in epilepsy research, we additionally tested the FreeSurfer hippocampus scripts on both the FreeSurfer and FastSurfer segmentations.As part of a prospective study, we performed both a 3 T MRI and a 7 T MRI on patients with non-lesional epilepsy initially diagnosed on 3 T. FreeSurfer and FastSurfer segmented and volumetrically measured both data sets using T1-weighted MPRAGE. We also performed hippocampal subfield volumetry and calculated inter-scanner variability.We found significant differences between FreeSurfer and FastSurfer at both 3 and 7 T, with FastSurfer typically producing higher volumetric estimates. We detected significant deviations in FreeSurfer in the subsegmentation of the left hippocampus on 7 T caused by inhomogeneities. The hippocampus segmentation on 3 T demonstrated overall greater homogeneity.Both methods and field strengths possess inherent advantages and limitations, resulting in differences in segmentation outcomes. Pre-processing can partially mitigate these discrepancies.
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000281880 650_7 $$2Other$$a7-Tesla (7 T)
000281880 650_7 $$2Other$$aFastSurfer
000281880 650_7 $$2Other$$aFreeSurfer
000281880 650_7 $$2Other$$aepilepsy
000281880 650_7 $$2Other$$ahippocampal subfields
000281880 7001_ $$00000-0002-5433-1572$$aKhadhraoui, Eya$$b1
000281880 7001_ $$0P:(DE-2719)9002802$$aEinspänner, Eric$$b2$$udzne
000281880 7001_ $$aKukhlenko, Olga$$b3
000281880 7001_ $$aBehme, Daniel$$b4
000281880 7001_ $$aBüntjen, Lars$$b5
000281880 7001_ $$00000-0003-0361-9215$$aSchmitt, Friedhelm C$$b6
000281880 7001_ $$00000-0003-2147-9797$$aMüller, Sebastian Johannes$$b7
000281880 773__ $$0PERI:(DE-600)2653586-5$$a10.21037/qims-2025-1263$$gVol. 15, no. 11, p. 11408 - 11426$$n11$$p11408 - 11426$$tQuantitative imaging in medicine and surgery$$v15$$x2223-4292$$y2025
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