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@ARTICLE{Schwarzer:281880,
      author       = {Schwarzer, Johannes and Khadhraoui, Eya and Einspänner,
                      Eric and Kukhlenko, Olga and Behme, Daniel and Büntjen,
                      Lars and Schmitt, Friedhelm C and Müller, Sebastian
                      Johannes},
      title        = {{C}omparison of brain volumetry in patients with
                      non-lesional epilepsy on 3 and 7 {T} {MPRAGE}.},
      journal      = {Quantitative imaging in medicine and surgery},
      volume       = {15},
      number       = {11},
      issn         = {2223-4292},
      address      = {Hong Kong},
      publisher    = {AME Publ.},
      reportid     = {DZNE-2025-01251},
      pages        = {11408 - 11426},
      year         = {2025},
      abstract     = {7 Tesla (T) magnetic resonance imaging (MRI) provides more
                      accurate image resolution than 3 T MRI due to its higher
                      field strength. This could lead to a significant improvement
                      in diagnostics, especially in small anatomical regions like
                      the substructures of the hippocampus and amygdala. However,
                      inhomogeneities arise due to higher field strengths, which
                      could reduce this benefit. We compared current segmentations
                      between 3 and 7 T in a clinical setup. The aim of this study
                      was to evaluate the feasibility of FreeSurfer and FastSurfer
                      at 7 T MRI in comparison to 3 T MRI. Since the hippocampus
                      and amygdala also play an important role in epilepsy
                      research, we additionally tested the FreeSurfer hippocampus
                      scripts on both the FreeSurfer and FastSurfer
                      segmentations.As part of a prospective study, we performed
                      both a 3 T MRI and a 7 T MRI on patients with non-lesional
                      epilepsy initially diagnosed on 3 T. FreeSurfer and
                      FastSurfer segmented and volumetrically measured both data
                      sets using T1-weighted MPRAGE. We also performed hippocampal
                      subfield volumetry and calculated inter-scanner
                      variability.We found significant differences between
                      FreeSurfer and FastSurfer at both 3 and 7 T, with FastSurfer
                      typically producing higher volumetric estimates. We detected
                      significant deviations in FreeSurfer in the subsegmentation
                      of the left hippocampus on 7 T caused by inhomogeneities.
                      The hippocampus segmentation on 3 T demonstrated overall
                      greater homogeneity.Both methods and field strengths possess
                      inherent advantages and limitations, resulting in
                      differences in segmentation outcomes. Pre-processing can
                      partially mitigate these discrepancies.},
      keywords     = {7-Tesla (7 T) (Other) / FastSurfer (Other) / FreeSurfer
                      (Other) / epilepsy (Other) / hippocampal subfields (Other)},
      cin          = {AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41209181},
      pmc          = {pmc:PMC12591911},
      doi          = {10.21037/qims-2025-1263},
      url          = {https://pub.dzne.de/record/281880},
}