282575 20260105130517.0 pmc:PMC12703981 pmc 10.1016/j.ebiom.2025.106040 doi pmid:41314150 pmid DZNE-2025-01335 English 610 Held, Nina Rebecca P:(DE-2719)9003256 0 dzne Quantitative susceptibility mapping at 7T as a biomarker of post- and interictal extravascular iron in patients with focal epilepsy. Amsterdam [u.a.] 2025 Elsevier article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1764936831_11989 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Iron deposition in the brain has been associated with epilepsy, but its anatomical distribution and its temporal association to seizures remain unclear. Here, we investigate brain iron in individuals with focal epilepsy using interictal and postictal quantitative susceptibility mapping (QSM) at 7 T MRI and explore its functional relevance.80 consecutive participants with focal epilepsy undergoing presurgical evaluation and 50 healthy controls were included. 8/80 participants with focal epilepsy had interictal and postictal scans. High-resolution T1- and susceptibility-weighted images were acquired and processed using custom pipelines for QSM. Seizure onset zones were determined by expert consensus, and neuropsychological assessments included memory and mood. Parcel-wise analyses examined group differences and correlations with cognitive scores, controlling for age and sex.Participants with focal epilepsy showed significantly higher interictal susceptibility, which colocalised with the presumed seizure onset zone. Impaired memory performance and more severe depressive symptoms were correlated with higher interictal susceptibility. Postictal susceptibility was significantly higher than interictal susceptibility and associated to the number of preceding seizures.QSM reflects both ictal iron extravasation and interictal iron accumulation. If further validated, it may help to non-invasively delineate the epileptogenic zone and become a long-term biomarker for seizure-burden.N.R.H. and T.Bauer were supported by the BONFOR research commission of the Medical Faculty of the University of Bonn. T.Bauer was funded by the Deutsche Forschungsgemeinschaft. T.Bauer., L.W., A.L. and T.R. are funded by the German Ministry for Research, Technology and Space. 354 - Disease Prevention and Healthy Aging (POF4-354) G:(DE-HGF)POF4-354 POF4-354 POF IV 0 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 1 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Blood–brain-barrier dysfunction Other Neuroinflammation Other Postictal imaging Other Ultra-high-field MRI Other Humans MeSH Male MeSH Female MeSH Adult MeSH Iron: metabolism MeSH Epilepsies, Partial: metabolism MeSH Epilepsies, Partial: diagnostic imaging MeSH Epilepsies, Partial: diagnosis MeSH Epilepsies, Partial: physiopathology MeSH Biomarkers: metabolism MeSH Magnetic Resonance Imaging: methods MeSH Middle Aged MeSH Young Adult MeSH Brain: diagnostic imaging MeSH Brain: metabolism MeSH Brain Mapping MeSH Case-Control Studies MeSH Disease Susceptibility MeSH Bauer, Tobias P:(DE-2719)9002598 1 dzne Stirnberg, Rüdiger P:(DE-2719)2810697 2 dzne Recke, Theda von der 3 Lehnen, Nils Christian 4 Baumgartner, Tobias 5 Witt, Juri-Alexander 6 Rácz, Attila 7 Pukropski, Jan 8 Walger, Lennart 9 von Wrede, Randi 10 Badr, Mostafa 11 Wolf, David 12 Kersting, Lennart Nils 13 Lange, Annalena 14 Bisten, Justus 15 Schmidt, Markus 16 Pracht, Eberhard P:(DE-2719)2810559 17 dzne Löwen, Daniel P:(DE-2719)9001317 18 dzne Faber, Jennifer P:(DE-2719)2811327 19 dzne Helmstaedter, Christoph 20 Reuter, Martin P:(DE-2719)2812134 21 dzne Friedman, Alon 22 Radbruch, Alexander P:(DE-2719)9001861 23 dzne Surges, Rainer 24 Stöcker, Tony P:(DE-2719)2810538 25 dzne Rüber, Theodor P:(DE-HGF)0 26 Last author 10.1016/j.ebiom.2025.106040 Vol. 122, p. 106040 - PERI:(DE-600)2799017-5 106040 EBioMedicine 122 2025 2352-3964 OpenAccess http://pub.dzne.de/record/282575/files/DZNE-2025-01335.pdf OpenAccess pdfa http://pub.dzne.de/record/282575/files/DZNE-2025-01335.pdf?subformat=pdfa oai:pub.dzne.de:282575 openaire open_access VDB driver dnbdelivery External Institute I:(DE-HGF)0 Extern 0 P:(DE-2719)9003256 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)9002598 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2810697 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 17 P:(DE-2719)2810559 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 18 P:(DE-2719)9001317 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 19 P:(DE-2719)2811327 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 21 P:(DE-2719)2812134 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 23 P:(DE-2719)9001861 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 25 P:(DE-2719)2810538 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 26 P:(DE-HGF)0 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-354 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Prevention and Healthy Aging 0 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 1 2025 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2025-01-07 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2025-01-07 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC JCR StatID:(DE-HGF)0100 StatID EBIOMEDICINE : 2022 2025-01-07 IF >= 10 StatID:(DE-HGF)9910 StatID EBIOMEDICINE : 2022 2025-01-07 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2023-05-02T08:51:17Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2023-05-02T08:51:17Z WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2025-01-07 Fees StatID:(DE-HGF)0700 StatID 2025-01-07 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2025-01-07 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Anonymous peer review 2023-05-02T08:51:17Z Article Processing Charges StatID:(DE-HGF)0561 StatID 2025-01-07 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-01-07 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2025-01-07 I:(DE-2719)1013026 AG Stöcker MR Physics 0 I:(DE-2719)1011001 Clinical Research (Bonn) Clinical Research Coordination 1 I:(DE-2719)1040310 AG Reuter Artificial Intelligence in Medicine 2 I:(DE-2719)5000075 AG Radbruch Clinical Neuroimaging 3 journal VDB UNRESTRICTED I:(DE-2719)1013026 I:(DE-2719)1011001 I:(DE-2719)1040310 I:(DE-2719)5000075 FullTexts