282586 20251219103450.0 10.1177/23969873251342048 doi pmid:40501059 pmid pmc:PMC12162553 pmc 2396-9873 ISSN 2396-9881 ISSN DZNE-2025-01346 English 610 von Danwitz, Niklas M P:(DE-2719)9002283 0 First author Patterns and predictors of delayed functional independence and dependence after thrombectomy in large vessel occlusion stroke: A multicenter analysis. London 2025 Sage Publishing article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1766051416_31259 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Predicting functional outcomes following endovascular treatment (EVT) for large-vessel occlusion stroke (LVOS) is challenging. Some patients achieve functional independence (modified Rankin Scale (mRS) 0 -2) at 90 days despite being dependent at discharge, termed delayed functional independence (DFI), while others lose independence after discharge, termed delayed functional dependence (DFD). This study explores patterns and predictors of DFI and DFD in LVOS patients undergoing EVT.We analyzed anterior circulation LVOS patients from the prospective multicenter German Stroke Registry. Multivariable logistic regression models identified independent predictors of DFI and DFD.Of 5909 patients, 2346 were independent at discharge, with 16.1% experiencing DFD at 90 days. DFD was associated with older age (median 78 vs 69 years, p < 0.001), female sex (61.4% vs 46.1%, p < 0.001), and greater stroke severity. Variables associated with DFD in multivariable analysis included older age, female sex, higher premorbid and discharge mRS, higher NIHSS at discharge, and absence of IV thrombolysis. Of 3563 patients dependent at discharge, 20.6% achieved DFI. DFI patients were younger (median 71 vs 77 years, p < 0.001), less likely female (38.7% vs 52.6%, p < 0.001) and had lower admission NIHSS, better pre-stroke functional status, higher ASPECTS and more frequent successful recanalization. Variables associated with DFI in multivariable analysis included younger age, male sex, better pre-stroke functional status, lower stroke severity and successful recanalization.Both DFD and DFI are frequent in clinical practice, with higher DFD and lower DFI rates in women, which warrants further investigation. Understanding these predictors can enhance individualized patient counseling and management strategies. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 354 - Disease Prevention and Healthy Aging (POF4-354) G:(DE-HGF)POF4-354 POF4-354 POF IV 1 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Stroke Other delayed dependence Other endovascular treatment Other functional dependence Other functional independence Other mechanical thrombectomy Other outcome Other Humans MeSH Female MeSH Male MeSH Aged MeSH Thrombectomy: methods MeSH Aged, 80 and over MeSH Middle Aged MeSH Treatment Outcome MeSH Recovery of Function MeSH Registries MeSH Ischemic Stroke: surgery MeSH Functional Status MeSH Prospective Studies MeSH Endovascular Procedures MeSH Stroke: surgery MeSH Germany MeSH Bode, Felix J P:(DE-2719)2811949 1 Samani, Omid Shirvani P:(DE-2719)9002936 2 Asperger, Hannah P:(DE-2719)9003181 3 dzne Ebrahimi, Taraneh P:(DE-2719)9003076 4 Kaesmacher, Johannes 5 Layer, Julia 0000-0001-5904-5316 6 Lehnen, Nils 7 Nitsch, Louisa 8 Meissner, Julius N 0000-0002-8980-9337 9 Odensass, Svenja 10 Stösser, Sebastian P:(DE-2719)9000778 11 dzne Thielscher, Christian P:(DE-2719)9002386 12 dzne Zidan, Mousa 0000-0002-5236-3992 13 Dorn, Franziska 14 Petzold, Gabor C P:(DE-2719)2810273 15 dzne Weller, Johannes M 0000-0001-5818-5392 16 10.1177/23969873251342048 Vol. 10, no. 4, p. 1292 - 1299 PERI:(DE-600)2851287-X 4 1292 - 1299 European stroke journal 10 2025 2396-9873 http://pub.dzne.de/record/282586/files/DZNE-2025-01346%20SUP.docx http://pub.dzne.de/record/282586/files/DZNE-2025-01346_Restricted.pdf http://pub.dzne.de/record/282586/files/DZNE-2025-01346_Restricted.pdf?subformat=pdfa pdfa http://pub.dzne.de/record/282586/files/DZNE-2025-01346%20SUP.doc http://pub.dzne.de/record/282586/files/DZNE-2025-01346%20SUP.odt http://pub.dzne.de/record/282586/files/DZNE-2025-01346%20SUP.pdf oai:pub.dzne.de:282586 VDB Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9002283 External Institute I:(DE-HGF)0 Extern 1 P:(DE-2719)2811949 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)9002936 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)9003181 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)9003076 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 0000-0001-5904-5316 External Institute I:(DE-HGF)0 Extern 11 P:(DE-2719)9000778 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 12 P:(DE-2719)9002386 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 15 P:(DE-2719)2810273 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-354 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Prevention and Healthy Aging 1 2025 National-Konsortium StatID:(DE-HGF)0430 StatID 2024-12-28 ger JCR StatID:(DE-HGF)0100 StatID EUR STROKE J : 2022 2024-12-28 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2024-12-28 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2024-12-28 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2024-12-28 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2024-12-28 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2024-12-28 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2024-12-28 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2024-12-28 IF >= 5 StatID:(DE-HGF)9905 StatID EUR STROKE J : 2022 2024-12-28 I:(DE-2719)1011401 Clinical Research Platform (CRP) Clinical Research Platform (CRP) 0 I:(DE-2719)1013020 AG Petzold Vascular Neurology 1 I:(DE-2719)1013038 AG Schultze Clinical Single Cell Omics (CSCO) / Systems Medicine 2 I:(DE-2719)1011101 Patient Studies (Bonn) Patient Studies (Bonn) 3 journal VDB I:(DE-2719)1011401 I:(DE-2719)1013020 I:(DE-2719)1013038 I:(DE-2719)1011101 UNRESTRICTED