283100 20260217130202.0 journal VDB UNRESTRICTED I:(DE-2719)5000075 I:(DE-2719)1011303 FullTexts DRIVER article DataCite Output Types/Journal article PUB:(DE-HGF)16 PUB:(DE-HGF) Journal Article journal journal 1767101377_6288 BibTeX ARTICLE ORCID JOURNAL_ARTICLE 0 EndNote Journal Article P:(DE-2719)2810687 Widmann, Catherine Nichols 1 P:(DE-2719)9000373 Kindler, Christine 2 dzne P:(DE-2719)9001860 Haase, Robert 3 P:(DE-HGF)0 Sauer, Malte 4 P:(DE-2719)2000008 Heneka, Michael 5 P:(DE-2719)9001861 Radbruch, Alexander 6 dzne P:(DE-2719)9001551 Schmeel, Frederic Carsten 7 Last author DZNE-2025-01507 http://pub.dzne.de/record/283100/files/DZNE-2025-1507.pdf OpenAccess http://pub.dzne.de/record/283100/files/DZNE-2025-1507.pdf?subformat=pdfa pdfa OpenAccess Background/Objectives: SARS-CoV-2 infection has been linked to long-term neurological sequelae and structural brain alterations. Previous analyses, including baseline results from the COVIMMUNE-Clin study, showed brain volume reductions in COVID-19 patients. Longitudinal data on progression are scarce. This study examined brain volume changes 12 months after baseline MRI in individuals who have recovered from mild or severe COVID-19 compared with controls. Methods: In this IRB-approved cohort study, 112 out of 172 recruited age- and sex-matched participants (38 controls, 36 mild/asymptomatic 38 severe COVID-19) underwent standardized brain MRI 12 months after baseline. Volumetric analysis was performed using AI-based software (mdbrain). Regional volumes were compared between groups with respect to absolute and normalized values. Multivariate regression controlled for demographics. Results: After 12 months, a significant decline in right hippocampal volume was observed across all groups, most pronounced in severe COVID-19 (SEV: Δ = -0.32 mL, p = 0.001). Normalized to intracranial volume, the reduction remained significant (SEV: Δ = -0.0003, p = 0.001; ASY: Δ = -0.0001, p = 0.001; CTL: minimal reduction, Δ ≈ 0, p = 0.005). Minor reductions in frontal and parietal lobes (e.g., right frontal SEV: Δ = -1.35 mL, p = 0.001), largely fell within physiological norms. These mild regional changes are consistent with expected ageing-related variability and do not suggest pathological progression. No widespread progressive atrophy was detected. Conclusions: This study demonstrates delayed, severity-dependent right hippocampal atrophy in recovered COVID-19 patients, suggesting long-term vulnerability of this memory-related region. In contrast, no progression of atrophy in other areas was observed. These findings highlight the need for extended post-COVID neurological monitoring, particularly of hippocampal integrity and its cognitive relevance. Other COVID-19 Other SARS-CoV-2 Other artificial intelligence Other brain atrophy Other hippocampal volume Other magnetic resonance imaging StatID:(DE-HGF)0200 StatID DBCoverage SCOPUS 2025-01-07 StatID:(DE-HGF)0160 StatID DBCoverage Essential Science Indicators 2025-01-07 LIC:(DE-HGF)CCBY4 HGFVOC Creative Commons Attribution CC BY 4.0 StatID:(DE-HGF)0600 StatID DBCoverage Ebsco Academic Search 2025-01-07 StatID:(DE-HGF)0100 StatID JCR DIAGNOSTICS : 2022 2025-01-07 StatID:(DE-HGF)0501 StatID DBCoverage DOAJ Seal 2024-08-29T10:48:13Z StatID:(DE-HGF)0500 StatID DBCoverage DOAJ 2024-08-29T10:48:13Z StatID:(DE-HGF)0113 StatID WoS Science Citation Index Expanded 2025-01-07 StatID:(DE-HGF)0700 StatID Fees 2025-01-07 StatID:(DE-HGF)0150 StatID DBCoverage Web of Science Core Collection 2025-01-07 StatID:(DE-HGF)9900 StatID IF < 5 2025-01-07 StatID:(DE-HGF)0510 StatID OpenAccess StatID:(DE-HGF)0030 StatID Peer Review ASC 2025-01-07 StatID:(DE-HGF)0561 StatID Article Processing Charges 2025-01-07 StatID:(DE-HGF)0300 StatID DBCoverage Medline 2025-01-07 StatID:(DE-HGF)1110 StatID DBCoverage Current Contents - Clinical Medicine 2025-01-07 StatID:(DE-HGF)0199 StatID DBCoverage Clarivate Analytics Master Journal List 2025-01-07 2025 I:(DE-588)1065079516 P:(DE-2719)9003165 Deutsches Zentrum für Neurodegenerative Erkrankungen 0 DZNE I:(DE-588)1065079516 P:(DE-2719)2810687 Deutsches Zentrum für Neurodegenerative Erkrankungen 1 DZNE I:(DE-HGF)0 P:(DE-2719)9000373 External Institute 2 Extern I:(DE-588)1065079516 P:(DE-2719)9001860 Deutsches Zentrum für Neurodegenerative Erkrankungen 3 DZNE I:(DE-588)1065079516 P:(DE-2719)2000008 Deutsches Zentrum für Neurodegenerative Erkrankungen 5 DZNE I:(DE-588)1065079516 P:(DE-2719)9001861 Deutsches Zentrum für Neurodegenerative Erkrankungen 6 DZNE I:(DE-588)1065079516 P:(DE-2719)9001551 Deutsches Zentrum für Neurodegenerative Erkrankungen 7 DZNE G:(DE-HGF)POF4-353 G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-300 G:(DE-HGF)POF4 G:(DE-HGF)POF DE-HGF Gesundheit Neurodegenerative Diseases Clinical and Health Care Research 0 Advancing Clinical Diagnosis with Artificial Intelligence: Applications, Challenges, and Future Directions PERI:(DE-600)2662336-5 10.3390/diagnostics15243244 Vol. 15, no. 24, p. 3244 - 24 3244 Diagnostics 15 2075-4418 2025 610 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Longitudinal Monitoring of Brain Volume Changes After COVID-19 Infection Using Artificial Intelligence-Based MRI Volumetry. pmc pmc:PMC12731685 doi 10.3390/diagnostics15243244 pmid pmid:41464243 Basel MDPI 2025 P:(DE-2719)9003165 Bendella, Zeynep 0 First author dzne English oai:pub.dzne.de:283100 openaire open_access VDB driver dnbdelivery G:(DE-HGF)POF4-353 353 - Clinical and Health Care Research (POF4-353) POF4-353 POF IV 0 I:(DE-2719)5000075 AG Radbruch Clinical Neuroimaging 0 I:(DE-2719)1011303 AG Heneka Neuroinflammation, Biomarker 1