284356 20260212105836.0 10.1371/journal.pone.0340182 doi DZNE-2026-00124 English 610 Wolff, Andreas P:(DE-2719)9003609 0 dzne Retrospective analysis of neurofilament-light chain in patients with inflammatory bowel disease – A pilot study San Francisco, California, US 2026 PLOS article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1770812631_18489 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Chronic inflammatory bowel diseases, encompassing Crohn's disease and ulcerative colitis, are characterized by persistent inflammation of the gastrointestinal tract. While traditionally regarded as confined to the gut, the systemic nature of inflammatory bowel disease has been increasingly recognized. The nervous system has garnered particular attention due to molecular and clinical evidence suggesting a potential interplay between inflammatory bowel disease and neurodegenerative diseases. Inflammatory bowel disease patients have a higher risk of developing neurological disorders such as Parkinson's disease, all-cause dementia, and multiple sclerosis. Still, causative molecular mechanisms are poorly understood. Neurofilament light chain (NfL) has been established as a disease-independent biomarker of axonal damage reflecting neurodegeneration.In this pilot study, we assessed molecular evidence of neurodegeneration by measuring serum NfL in a single-molecule array using the HD-X SIMOA platform (Quanterix, MA, USA) and employing correlation with clinical data in forty-nine patients with histopathologically confirmed inflammatory bowel disease. In total, 24 Crohn's disease patients, 25 ulcerative colitis patients, and 23 controls, aged 18-79 years, were included.We found an age-dependency of serological NfL levels, however, no apparent differences between disease groups and controls. Crohn's disease patients showed a slower age-dependent incline in serological NfL compared to control subjects (p = 0.03). No correlation of NfL with disease duration, disease severity, or inflammatory bowel disease treatment was found.A slower age-dependent increase in serological NfL levels was found in Crohn's disease patients compared to control subjects. Larger studies assessing additional markers of neurodegeneration may be instrumental in addressing this question in the future. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, Journals: pub.dzne.de Neurofilament Proteins NLM Chemicals neurofilament protein L NLM Chemicals Biomarkers NLM Chemicals Humans MeSH Neurofilament Proteins: blood MeSH Pilot Projects MeSH Adult MeSH Middle Aged MeSH Male MeSH Female MeSH Aged MeSH Biomarkers: blood MeSH Adolescent MeSH Young Adult MeSH Retrospective Studies MeSH Inflammatory Bowel Diseases: blood MeSH Crohn Disease: blood MeSH Crohn Disease: pathology MeSH Colitis, Ulcerative: blood MeSH Colitis, Ulcerative: pathology MeSH Case-Control Studies MeSH Feneberg, Emily 1 Shakhtour, Julius 2 Steiger, Katja 0000-0002-7269-5433 3 Schmid, Roland M. 4 Haller, Bernhard 5 Reinhardt, Nya 6 Middelhoff, Moritz 7 Schult-Hannemann, David 8 Lingor, Paul P:(DE-2719)2812561 9 Last author 10.1371/journal.pone.0340182 Vol. 21, no. 1, p. e0340182 - PERI:(DE-600)2267670-3 1 e0340182 PLOS ONE 21 2026 1932-6203 http://pub.dzne.de/record/284356/files/DZNE-2026-00124%20SUP.docx OpenAccess http://pub.dzne.de/record/284356/files/DZNE-2026-00124.pdf OpenAccess pdfa http://pub.dzne.de/record/284356/files/DZNE-2026-00124.pdf?subformat=pdfa http://pub.dzne.de/record/284356/files/DZNE-2026-00124%20SUP.doc http://pub.dzne.de/record/284356/files/DZNE-2026-00124%20SUP.odt http://pub.dzne.de/record/284356/files/DZNE-2026-00124%20SUP.pdf oai:pub.dzne.de:284356 openaire open_access VDB driver dnbdelivery External Institute I:(DE-HGF)0 Extern 0 P:(DE-2719)9003609 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 9 P:(DE-2719)2812561 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2026 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2024-12-16 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2024-12-16 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2024-12-16 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2024-12-16 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2024-12-16 DBCoverage StatID:(DE-HGF)1040 StatID Zoological Record 2024-12-16 JCR StatID:(DE-HGF)0100 StatID PLOS ONE : 2022 2024-12-16 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2024-02-08T09:37:46Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2024-02-08T09:37:46Z WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2024-12-16 Fees StatID:(DE-HGF)0700 StatID 2024-12-16 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2024-12-16 IF < 5 StatID:(DE-HGF)9900 StatID 2024-12-16 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2024-12-16 Article Processing Charges StatID:(DE-HGF)0561 StatID 2024-12-16 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2024-12-16 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2024-12-16 I:(DE-2719)1111015 Clinical Research (Munich) Clinical Research (Munich) 0 journal VDB UNRESTRICTED I:(DE-2719)1111015 FullTexts