285019 20260220105948.0 10.1002/alz70856_106502 doi 1552-5260 ISSN 1552-5279 ISSN DZNE-2026-00145 610 Lopez, Susanna 0 Alzheimer’s Association International Conference AAIC 25 Toronto 2025-07-27 - 2025-07-31 Canada Older adults with subjective memory complaints and brain amyloidosis show stable electroencephalographic rhythms, cortical structure, and cognitive performances over 2 years 2025 Abstract abstract abstract PUB:(DE-HGF)1 1771496315_26619 PUB:(DE-HGF) Conference Paper 33 EndNote INPROCEEDINGS BibTeX conferenceObject DRIVER Journal Article PUB:(DE-HGF)16 PUB:(DE-HGF) journal Output Types/Conference Abstract DataCite OTHER ORCID Background: It is well-known that in patients with Alzheimer's disease (AD) and high education attainment, cognitive performance is typically better than expected based on the burden of brain neuropathology and neurodegeneration (Stern et al., 2018; doi: 10.1016/j.neuroimage.2018.05.033). This resilience of the cognitive status was attributed to a sort of cognitive reserve (CR) accumulated by persons with high education attainment, which predicts a life with engaging job, intellectual, and social demands (Arenaza-Urquijo et al. 2015; doi: 10.3389/fnagi.2015.00134; Stern et al. 2018). Previous resting-state eyes-closed electroencephalographic (rsEEG) studies showed that alpha rhythms in posterior visual and visuospatial areas are related to CR in healthy adults, subjective memory complaints (SMC) seniors, and patients with mild cognitive impairment due to AD (ADMCI). Method: In the present exploratory study, we used the database of the INSIGHT cohort (Dubois et al., 2018; doi: 10.1016/S1474-4422(18)30029-2), we investigated whether older adults with subjective memory complaints (SMC) and brain amyloid-β accumulation may exhibit clinical progression over 2 years as a function of educational attainment (a proxy of cognitive reserve). Result: SMCneg with high educational attainment (Edu+) participants showed greater posterior rsEEG alpha rhythms compared to SMCneg with low educational attainment (Edu-) participants. In contrast, SMCpos Edu+ participants exhibited reduced posterior rsEEG alpha rhythms and parietal cortical thickness compared to SMCpos Edu- participants. No EEG (Figure 1) or MRI (Figure 2) marker significantly changed over the 2-year follow-up period. Conclusion: These findings suggest that a substantially longer time interval than 2 years should be assessed to evaluate the Alzheimer's disease progression and biomarker-guided targeted therapies in presymptomatic SMCpos adults. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, Journals: pub.dzne.de Hampel, Harald 1 Percio, Claudio Del 2 Noce, Giuseppe 3 Lizio, Roberta 4 Teipel, Stefan P:(DE-2719)2000026 5 dzne Dyrba, Martin P:(DE-2719)2810283 6 dzne Vergallo, Andrea 7 Ferri, Raffaele 8 Pardini, Matteo 9 Babiloni, Claudio 10 10.1002/alz70856_106502 Vol. 21, no. S2, p. e106502 PERI:(DE-600)2201940-6 S2 e106502 Alzheimer's and dementia 21 2025 1552-5260 OpenAccess http://pub.dzne.de/record/285019/files/DZNE-2026-00145.pdf OpenAccess pdfa http://pub.dzne.de/record/285019/files/DZNE-2026-00145.pdf?subformat=pdfa oai:pub.dzne.de:285019 openaire open_access VDB driver dnbdelivery External Institute I:(DE-HGF)0 Extern 5 P:(DE-2719)2000026 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)2810283 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2025-11-11 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2025-11-11 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC JCR StatID:(DE-HGF)0100 StatID ALZHEIMERS DEMENT : 2022 2025-11-11 IF >= 10 StatID:(DE-HGF)9910 StatID ALZHEIMERS DEMENT : 2022 2025-11-11 DEAL Wiley StatID:(DE-HGF)3001 StatID 2025-11-11 ger WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2025-11-11 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2025-11-11 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2025-11-11 OpenAccess StatID:(DE-HGF)0510 StatID DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-11-11 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2025-11-11 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2025-11-11 I:(DE-2719)1510100 AG Teipel Clinical Dementia Research (Rostock /Greifswald) 0 abstract VDB UNRESTRICTED journal I:(DE-2719)1510100 FullTexts