285805 20260401135951.0 10.1097/RLI.0000000000001252 doi pmid:41416735 pmid 0020-9996 ISSN 1536-0210 ISSN DZNE-2026-00341 English 610 Faber, Jennifer P:(DE-2719)2811327 0 First author Ready for Routine: Homogeneous, High-Resolution, and Multicontrast Whole-Brain MRI at 7 Tesla in Short Scan Time With 'plug-and-Play' pTx Sequences. Philadelphia, Pa. 2025 Lippincott Williams & Wilkins article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1775044439_19741 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote 7T MRI received FDA/CE clearance almost 7 years ago. However, until today, it has not yet been widely adopted in clinical routine. This is mainly due to field inhomogeneities that impede whole-brain coverage. Moreover, the long scan times often associated with high-resolution imaging are an additional limiting factor.To combine calibration-free parallel transmit technology (pTx) using universal pulses (UP) with advanced imaging acceleration strategies to achieve homogenous multicontrast 7T MRI with whole-brain coverage and high spatial resolution in short scan time.Ten healthy volunteers were scanned both with conventional vendor-provided sequences and with custom sequences for anatomical whole-brain imaging [-weighted, -weighted, FLAIR, and susceptibility-weighted]. The scan times for the 2 anatomical protocols were matched (25 minutes). In addition, a quantitative MRI protocol [multi-parametric mapping (MPM) and chemical exchange saturation transfer (CEST)] was scanned twice using custom sequences with conventional (circular polarized) and UPs, respectively, in a scan time of 2×25 minutes. Moreover, 4 patients with different neurological diseases were scanned, namely temporal lobe epilepsy, spinocerebellar ataxia, cerebral amyloid angiopathy, and glioblastoma. For the patients, only optimized custom sequences with UPs were acquired.Compared with conventional implementations, the custom sequences provide strongly improved image homogeneity and quality with significantly higher SNR and CNR across the whole brain, including cerebellum and brain stem. Moreover, UPs improve the repeatability of derived quantitative parameters. The suggested protocol has additionally been successfully demonstrated in 4 patients with different neurological pathologies.Homogeneous whole-brain 7T MRI with high spatial resolution and high image quality is possible in clinically feasible scan times. The developed protocol can be applied without any expert knowledge and is ready for clinical use. The approach could largely extend applicability of UHF MRI in neuroradiology paving the way for increased routine use of 7T MRI. 354 - Disease Prevention and Healthy Aging (POF4-354) G:(DE-HGF)POF4-354 POF4-354 POF IV 0 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 1 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de 7 Tesla Other 7T Other CEST Other MPM Other MPRAGE Other infratentorial structures Other neuroradiology Other pTx Other ultra-high field Other Paech, Daniel P:(DE-2719)9001705 1 dzne Pracht, Eberhard P:(DE-2719)2810559 2 dzne Stirnberg, Rüdiger P:(DE-2719)2810697 3 dzne Ehses, Philipp P:(DE-2719)2812222 4 dzne Völzke, Yannik P:(DE-2719)2811521 5 Löwen, Daniel P:(DE-2719)9001317 6 dzne Ferreira, Mónica P:(DE-2719)9003289 7 dzne Brunheim, Sascha P:(DE-2719)2812752 8 dzne Boulant, Nicolas 9 Gras, Vincent 10 Mauconduit, Franck P:(DE-2719)9002043 11 Massire, Aurélien 12 Goa, Pal Erik P:(DE-2719)9002873 13 dzne Lamalle, Laurent 14 Rüber, Theodor 15 Bauer, Tobias P:(DE-2719)9002598 16 dzne Petzold, Gabor C P:(DE-2719)2810273 17 dzne Nordsiek, Julia P:(DE-2719)9001884 18 Schneider, Matthias 19 Schaub, Christina 20 Klockgether, Thomas P:(DE-2719)2810314 21 dzne Radbruch, Alexander P:(DE-2719)9001861 22 dzne Stöcker, Tony P:(DE-2719)2810538 23 Last author dzne 10.1097/RLI.0000000000001252 PERI:(DE-600)2041543-6 - Investigative radiology Advance online publication 2025 0020-9996 http://pub.dzne.de/record/285805/files/DZNE-2026-00341_Restricted.pdf http://pub.dzne.de/record/285805/files/DZNE-2026-00341_Restricted.pdf?subformat=pdfa pdfa Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2811327 External Institute I:(DE-HGF)0 Extern 1 P:(DE-2719)9001705 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2810559 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2810697 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2812222 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)2811521 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)9001317 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)9003289 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 8 P:(DE-2719)2812752 External Institute I:(DE-HGF)0 Extern 13 P:(DE-2719)9002873 External Institute I:(DE-HGF)0 Extern 16 P:(DE-2719)9002598 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 17 P:(DE-2719)2810273 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 18 P:(DE-2719)9001884 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 21 P:(DE-2719)2810314 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 22 P:(DE-2719)9001861 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 23 P:(DE-2719)2810538 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-354 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Prevention and Healthy Aging 0 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 1 Allianz-Lizenz StatID:(DE-HGF)0410 StatID 2025-11-10 ger JCR StatID:(DE-HGF)0100 StatID INVEST RADIOL : 2022 2025-11-10 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2025-11-10 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-11-10 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2025-11-10 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2025-11-10 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2025-11-10 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2025-11-10 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2025-11-10 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2025-11-10 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2025-11-10 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2025-11-10 IF >= 5 StatID:(DE-HGF)9905 StatID INVEST RADIOL : 2022 2025-11-10 I:(DE-2719)1013026 AG Stöcker MR Physics 0 I:(DE-2719)1011001 Clinical Research (Bonn) Clinical Research Coordination 1 I:(DE-2719)5000075 AG Radbruch Clinical Neuroimaging 2 I:(DE-2719)1013020 AG Petzold Vascular Neurology 3 I:(DE-2719)1011101 Patient Studies (Bonn) Patient Studies (Bonn) 4 journal EDITORS VDBINPRINT I:(DE-2719)1013026 I:(DE-2719)1011001 I:(DE-2719)5000075 I:(DE-2719)1013020 I:(DE-2719)1011101 UNRESTRICTED