285806 20260401140558.0 10.1109/EMBC58623.2025.11253841 doi pmid:41337179 pmid DZNE-2026-00342 English Emery, Brett Addison P:(DE-2719)9001361 0 First author dzne 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBC Copenhagen 2025-07-14 - 2025-07-18 Denmark Spatiotemporal Mapping of Epileptiform Dynamics in the Hippocampal Circuit via High-Density Biosensors. 2025 IEEE 2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : [Proceedings] - IEEE, 2025. - ISBN 979-8-3315-8618-8 - doi:10.1109/EMBC58623.2025.11253841 1-4 CONFERENCE_PAPER ORCID Conference Paper 33 EndNote INPROCEEDINGS BibTeX conferenceObject DRIVER Output Types/Conference Paper DataCite Contribution to a conference proceedings contrib contrib PUB:(DE-HGF)8 1775044992_19839 PUB:(DE-HGF) Contribution to a book PUB:(DE-HGF)7 PUB:(DE-HGF) contb Missing Journal: Annu Int Conf IEEE Eng Med Biol Soc = 2375-7477 (import from CrossRef Conference, PubMed, , Journals: pub.dzne.de) 70 million people suffer from epilepsy worldwide with temporal lobe epilepsy (TLE) being the most common focal epilepsy in adults. The hippocampus, a region associated with TLE, is highly susceptible to pathological synchronization and epileptogenesis due to its functional and anatomical organization. Despite progress, understanding the distinct contributions of hippocampal subregions to multiplexed activation and hyperactivity remains challenging due to the interplay of receptor dynamics, ion channel regulation, and network synchronization. Here, a large-scale ex-vivo electrophysiological platform was implemented using a high-density CMOS-based biosensor (HD-MEA) to probe the spatiotemporal dynamics of 4AP and ATPA, benchmark compounds for inducing hyperactivity, within the hippocampal circuit. This approach demonstrates the use of large-scale biosensors to address these challenges by enabling high-resolution spatiotemporal mapping of circuit activity, demonstrating their potential to uncover ion channel and receptor-specific spatiotemporal signatures of hyperactivity. 351 - Brain Function (POF4-351) G:(DE-HGF)POF4-351 POF4-351 POF IV 0 Dataset connected to CrossRef Conference, PubMed, , Journals: pub.dzne.de Biosensing Techniques: methods MeSH Biosensing Techniques: instrumentation MeSH Hippocampus: physiopathology MeSH Animals MeSH Epilepsy: physiopathology MeSH Epilepsy, Temporal Lobe: physiopathology MeSH Spatio-Temporal Analysis MeSH Humans MeSH Khanzada, Shahrukh P:(DE-2719)9001867 1 dzne Hu, Xin P:(DE-2719)2814182 2 dzne Amin, Hayder P:(DE-2719)2812628 3 Last author dzne 10.1109/EMBC58623.2025.11253841 http://pub.dzne.de/record/285806/files/DZNE-2026-00342_Restricted.pdf http://pub.dzne.de/record/285806/files/DZNE-2026-00342_Restricted.pdf?subformat=pdfa pdfa Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9001361 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)9001867 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2814182 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2812628 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-351 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Brain Function 0 I:(DE-2719)1710010 AG Amin Biohybrid Neuroelectronics (BIONICS) 0 contrib EDITORS VDBINPRINT contb I:(DE-2719)1710010 UNRESTRICTED