engHu, XinKhanzada, ShahrukhEmery, Brett AddisonAmin, HayderA Computational Framework for Learning and Memory: Network Motif Evolution During LTP-Induced Plasticity.Long-Term Potentiation: physiologyAnimalsMemory: physiologyNeuronal Plasticity: physiologyLearning: physiologyModels, NeurologicalRatsNerve Net: physiologyUnraveling the complexity of network-level synaptic plasticity remains a challenge due to the dynamic and interconnected nature of neural circuits. In this study, we employ network motifs-recurrent, functionally specialized patterns of connectivity-as a framework to dissect long-term potentiation (LTP)-induced reorganization in hippocampal CA1-CA3 networks. Using network LTP recordings from highdensity microelectrode arrays (HD-MEA), we systematically tracked motif evolution before and after high-frequency stimulation, assessing their roles in network stability, synaptic strength modulation, and criticality-redundancy trade-offs, linking these dynamics to firing synchrony and network potentiation. The Graph-theoretic analysis further demonstrated that LTP-induced reorganization follows a structured motif-guided trajectory, with early-phase motif recruitment optimizing efficiency, followed by phase-dependent refinement. These findings provide new insights into how structured connectivity enables network-level plasticity, balancing efficiency with stability, and offer a potential framework for understanding memory encoding mechanisms and their dysfunction in neurological disorders.IEEE 1-4 (2025). doi:10.1109/EMBC58623.2025.11254218info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersion2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : [Proceedings] - IEEE, 2025. - ISBN 979-8-3315-8618-8 - doi:10.1109/EMBC58623.2025.112542182025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : [Proceedings] - IEEE, 2025. - ISBN 979-8-3315-8618-8 - doi:10.1109/EMBC58623.2025.11254218<br/>47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC, Copenhagen, Denmark, 2025-07-14 - 2025-07-18IEEE2025info:eu-repo/semantics/closedAccessDEhttps://pub.dzne.de/record/285807https://pub.dzne.de/search?p=id:%22DZNE-2026-00343%22Researchersinfo:eu-repo/semantics/altIdentifier/doi/10.1109/EMBC58623.2025.11254218info:eu-repo/semantics/altIdentifier/pmid/pmid:41336996