engLim, Kai ShiPeriñan, Maria TeresaKaiyrzhanov, RauanDivya, K. P.Pal, PramodKukkle, Prashanth LingappaRajan, RoopaBorgohain, RupamSalari, MehriQuattrone, AndreaValente, Enza MariaAvenali, MicolParnetti, LucillaHoulden, HenrySchirinzi, TommasoShiraishi, TomotakaKarimova, AltynayKaishibayeva, GulnazShambetova, CholponKrüger, RejkoAbdul Murad, Nor AzianAzmin, ShahrulMohamed, WaelMartinez-Ramirez, DanielIsayan, MariamRodriguez-Violante, MayelaReayes-Perez, PaulaTserensodnom, BayasgalanOjha, RajeevAnderson, Tim J.Pitcher, Toni L.Ojo, OluwadamilolaAasly, Jan O.Pihlstrøm, LasseTan, ManuelaTay, Yi WenUr-Rehman, ShoaibCornejo-Olivas, MarioDoquenia, Maria LeilaRosales, RaymondVinuela, AngelIakovenko, ElenaMubarak, Bashayer AlUmair, MuhammadAmod, FerzanaCarr, JonathanToh, Tzi ShinBardien, SorayaJeon, BeomseokKim, Yun JoongCubo, EstherAlvarez, IgnacioHoenicka, JanetBeyer, KatrinPastor, PauEl-Sadig, SarahZweier, ChristianeLit, Lei-ChengKrack, PaulWu, Ruey-MeeiWu, Hsiu-ChuanWu, Yih-RuKung, Pin-JuiWu, SerenaAmouri, RimSassi, Samia BenBaşak, A. NazlÇakmak, Özgür ÖztopKhairul Anuar, Anis NadhirahErtan, SibelGenc, GencerMartínez-Carrasco, AlejandroSchrag, AnetteSchapira, AnthonyStafford, Eleanor J.Morris, HuwHardy, JohnWood, NicholasOkunoye, OlaitanDing, Hans XingWeil, RimonaJasaitye, SimonaObese, VidaCarroll, CamilleBale, ClaireGrosset, DonaldMok, Kin Y.Williams, NigelLewis, Patrick A.Love, SethScreven, LaurelStott, SimonEspay, AlbertoMarsili, LucaO’Grady, AlyssaSiddiqi, BernadetteCasey, BradfordFiske, BrianComart, CharisseSolle, Justin C.Murphy, KaileighIbrahim, Norlinah MohamedKuhl, MaggieLouie, NaomiChowdhury, SohiniSherer, ToddSobering, Andrew K.Jonas, CabellCruchaga, CarlosPantazis, Caroline B.Wegel, ClaireHall, DeborahChew, Elaine Guo YanLin, Chin-HsienShamim, EjazWilliamson, JaredRiley, EkeminiDumanis, SonyaSerrano, Geidy E.Beach, ThomasChen, HongleiKeller Sarmiento, Ignacio JuanMencacci, Niccolò E.Lubbe, StevenKim, Han-JoonJankovic, JosephInca-Martinez, MiguelShulman, JoshuaNuytemans, KarenKieburtz, KarlMarkopoulou, KaterinaMarek, KennethChahine, Lana M.Ruffrage, LaurenDean, MarissaLee, Jee-YoungShulman, LisaAlbin, RogerAlcalay, RoyWalker, RuthXie, TaoForoud, TatianaNguyen, DuanNguyen, ToanAtadzhanov, MasharipChung, Sun JuFoo, Jia NeeTan, Eng-KingLim, Shen-YangTan, Ai HueyBandres-Ciga, SaraAhmad-Annuar, AzlinaLee, Paul SuhwanYan Chew, Elaine GuoKhairul Anuar, Anis NadhirahRizig, MieOkubadejo, NjidekaGatto, Emilia M.Kauffman, MarceloKhachatryan, SamsonTavadyan, ZaruhiShepherd, Claire E.Hunter, JulieAkçimen, FulyaKumar, KishoreEllis, MelinaRentería, Miguel E.Koks, SulevZimprich, AlexanderRieder, CarlosTumas, VitorCamargos, SarahFon, Edward A.Fon, TedLim, Jia LunMonchi, OuryGalleguillos, Benjamin PizarroOlguin, PatricioMiranda, MarceloBustamante, Maria LeonorTang, BeishaShang, HuifangGuo, JifengChan, PiuLuo, WeiKoretsky, Mathew J.Arboleda, GonzaloOrozco, Jorgedel Rio, Marlene JimenezHernandez, AlvaroSalama, MohamedKamel, Walaa A.Zewde, Yared Z.Brice, AlexisCorvol, Jean-ChristopheWestenberger, AnaFunayama, ManabuKlein, ChristineVollstedt, Eva-JulianeMadoev, HarutyunTrinh, JoanneJunker, JohannaLohmann, KatjaIllarionova, AnastasiaMollenhauer, BritHopfner, FranziskaHöglinger, GünterYoshino, HiroyoLange, Lara M.Sharma, ManuGasser, ThomasFang, Zih-HuaGroppa, SergioAkpalu, AlbertXiromerisiou, GeorgiaHadjigeorgiou, GeorgiosDardiotis, EfthymiosDagklis, IoannisHattori, NobutakaTarnanas, IoannisStefanis, LeonidasStamelou, MariaMedina, AlexChan, Germaine Hiu-FaiCheung, Nelson Yuk-FaiIp, NancyChan, PhillipZhou, XiaopuKishore, AshaAssociation of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onsetinfo:eu-repo/classification/ddc/610Common and rare variants in LRRK2 influence Parkinson’s disease (PD) risk across diverse populations, and in this study, the rare p.A419V variant was investigated across multiple ancestry cohorts comprising over 200,000 PD cases and controls. In cases of East Asian (EAS) ancestry, p.A419V was significantly associated with increased risk of PD (OR = 2.9; 95% CI: 1.66–5.10; p = 0.0002), and was not in linkage disequilibrium with other LRRK2 coding variants. The variant was significantly associated with a lower age at PD onset in the study cohort, while a meta-analysis of the EAS cases indicated a similar, albeit non-significant trend. LRRK2 protein modelling prediction indicated that binding sites for RAB8A, RAB29 and RAB32 were in close proximity to the p.A419V variant within the ARM domain. Together, these findings confirm the p.A419V as a significant PD risk factor in EAS populations, as well as highlight disease-relevant variants in the ARM domain and the link with LRRK2-RAB signaling.npj Parkinson's Disease 12(1), 51 (2026). doi:10.1038/s41531-026-01265-3info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionSpringer Nature2026info:eu-repo/semantics/closedAccessDEhttps://pub.dzne.de/record/285811https://pub.dzne.de/search?p=id:%22DZNE-2026-00347%22Researchersinfo:eu-repo/semantics/altIdentifier/issn/2373-8057info:eu-repo/semantics/altIdentifier/doi/10.1038/s41531-026-01265-3