17 Lim, Kai Shi Periñan, Maria Teresa Chew, Elaine Guo Yan Lee, Paul Suhwan Akçimen, Fulya Lim, Jia Lun Koretsky, Mathew J. Funayama, Manabu Yoshino, Hiroyo Hattori, Nobutaka Kaiyrzhanov, Rauan Houlden, Henry Isayan, Mariam Tay, Yi Wen Toh, Tzi Shin Lit, Lei-Cheng Khairul Anuar, Anis Nadhirah Ding, Hans Xing Screven, Laurel Ibrahim, Norlinah Mohamed Lin, Chin-Hsien Kim, Han-Joon Lee, Jee-Young Chung, Sun Ju Foo, Jia Nee Tan, Eng-King Lim, Shen-Yang Tan, Ai Huey Bandres-Ciga, Sara Ahmad-Annuar, Azlina Yan Chew, Elaine Guo Khairul Anuar, Anis Nadhirah Rizig, Mie Okubadejo, Njideka Gatto, Emilia M. Kauffman, Marcelo Khachatryan, Samson Tavadyan, Zaruhi Shepherd, Claire E. Hunter, Julie Kumar, Kishore Ellis, Melina Rentería, Miguel E. Koks, Sulev Zimprich, Alexander Rieder, Carlos Tumas, Vitor Camargos, Sarah Fon, Edward A. Fon, Ted Monchi, Oury Galleguillos, Benjamin Pizarro Olguin, Patricio Miranda, Marcelo Bustamante, Maria Leonor Tang, Beisha Shang, Huifang Guo, Jifeng Chan, Piu Luo, Wei Arboleda, Gonzalo Orozco, Jorge del Rio, Marlene Jimenez Hernandez, Alvaro Salama, Mohamed Kamel, Walaa A. Zewde, Yared Z. Brice, Alexis Corvol, Jean-Christophe Westenberger, Ana Klein, Christine Vollstedt, Eva-Juliane Madoev, Harutyun Trinh, Joanne Junker, Johanna Lohmann, Katja Illarionova, Anastasia Mollenhauer, Brit Hopfner, Franziska Höglinger, Günter Lange, Lara M. Sharma, Manu Gasser, Thomas Fang, Zih-Hua Groppa, Sergio Akpalu, Albert Xiromerisiou, Georgia Hadjigeorgiou, Georgios Dardiotis, Efthymios Dagklis, Ioannis Tarnanas, Ioannis Stefanis, Leonidas Stamelou, Maria Medina, Alex Chan, Germaine Hiu-Fai Cheung, Nelson Yuk-Fai Ip, Nancy Chan, Phillip Zhou, Xiaopu Kishore, Asha Divya, K. P. Pal, Pramod Kukkle, Prashanth Lingappa Rajan, Roopa Borgohain, Rupam Salari, Mehri Quattrone, Andrea Valente, Enza Maria Avenali, Micol Parnetti, Lucilla Schirinzi, Tommaso Shiraishi, Tomotaka Karimova, Altynay Kaishibayeva, Gulnaz Shambetova, Cholpon Krüger, Rejko Abdul Murad, Nor Azian Azmin, Shahrul Mohamed, Wael Martinez-Ramirez, Daniel Rodriguez-Violante, Mayela Reayes-Perez, Paula Tserensodnom, Bayasgalan Ojha, Rajeev Anderson, Tim J. Pitcher, Toni L. Ojo, Oluwadamilola Aasly, Jan O. Pihlstrøm, Lasse Tan, Manuela Ur-Rehman, Shoaib Cornejo-Olivas, Mario Doquenia, Maria Leila Rosales, Raymond Vinuela, Angel Iakovenko, Elena Mubarak, Bashayer Al Umair, Muhammad Amod, Ferzana Carr, Jonathan Bardien, Soraya Jeon, Beomseok Kim, Yun Joong Cubo, Esther Alvarez, Ignacio Hoenicka, Janet Beyer, Katrin Pastor, Pau El-Sadig, Sarah Zweier, Christiane Krack, Paul Wu, Ruey-Meei Wu, Hsiu-Chuan Wu, Yih-Ru Kung, Pin-Jui Wu, Serena Amouri, Rim Sassi, Samia Ben Başak, A. Nazl Çakmak, Özgür Öztop Ertan, Sibel Genc, Gencer Martínez-Carrasco, Alejandro Schrag, Anette Schapira, Anthony Stafford, Eleanor J. Morris, Huw Hardy, John Wood, Nicholas Okunoye, Olaitan Weil, Rimona Jasaitye, Simona Obese, Vida Carroll, Camille Bale, Claire Grosset, Donald Mok, Kin Y. Williams, Nigel Lewis, Patrick A. Love, Seth Stott, Simon Espay, Alberto Marsili, Luca O’Grady, Alyssa Siddiqi, Bernadette Casey, Bradford Fiske, Brian Comart, Charisse Solle, Justin C. Murphy, Kaileigh Kuhl, Maggie Louie, Naomi Chowdhury, Sohini Sherer, Todd Sobering, Andrew K. Jonas, Cabell Cruchaga, Carlos Pantazis, Caroline B. Wegel, Claire Hall, Deborah Shamim, Ejaz Williamson, Jared Riley, Ekemini Dumanis, Sonya Serrano, Geidy E. Beach, Thomas Chen, Honglei Keller Sarmiento, Ignacio Juan Mencacci, Niccolò E. Lubbe, Steven Jankovic, Joseph Inca-Martinez, Miguel Shulman, Joshua Nuytemans, Karen Kieburtz, Karl Markopoulou, Katerina Marek, Kenneth Chahine, Lana M. Ruffrage, Lauren Dean, Marissa Shulman, Lisa Albin, Roger Alcalay, Roy Walker, Ruth Xie, Tao Foroud, Tatiana Nguyen, Duan Nguyen, Toan Atadzhanov, Masharip AG Gasser ICRU npj Parkinson's Disease npj Parkinson's Disease Springer Nature [London] 2373-8057 10.1038/s41531-026-01265-3 51 1 12 Common and rare variants in LRRK2 influence Parkinson’s disease (PD) risk across diverse populations, and in this study, the rare p.A419V variant was investigated across multiple ancestry cohorts comprising over 200,000 PD cases and controls. In cases of East Asian (EAS) ancestry, p.A419V was significantly associated with increased risk of PD (OR = 2.9; 95% CI: 1.66–5.10; p = 0.0002), and was not in linkage disequilibrium with other LRRK2 coding variants. The variant was significantly associated with a lower age at PD onset in the study cohort, while a meta-analysis of the EAS cases indicated a similar, albeit non-significant trend. LRRK2 protein modelling prediction indicated that binding sites for RAB8A, RAB29 and RAB32 were in close proximity to the p.A419V variant within the ARM domain. Together, these findings confirm the p.A419V as a significant PD risk factor in EAS populations, as well as highlight disease-relevant variants in the ARM domain and the link with LRRK2-RAB signaling. PUB:(DE-HGF)16, ; 0, ; Journal Article 2026 DZNE-2026-00347 2026 https://pub.dzne.de/record/285811 https://doi.org/10.1038/s41531-026-01265-3