285816 20260402150430.0 10.1007/s11136-026-04229-5 doi pmid:41920450 pmid 0962-9343 ISSN 1573-2649 ISSN DZNE-2026-00352 English 100 Goodwin, Elizabeth 0000-0003-1351-9170 0 Measuring health-related quality of life in multiple sclerosis: comparing the acceptability, validity and responsiveness of the EQ-5D-3L and MSIS-8D. Cham 2026 Springer Nature Switzerland AG article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1775134909_16505 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Purpose: Concerns have been raised about the sensitivity and responsiveness of the EQ-5D, one of the most commonly used preference-based health-related quality of life measures, in the context of multiple sclerosis (MS). In response to these concerns, a condition-specific preference-based measure, the Multiple Sclerosis Impact Scale Eight Dimensions (MSIS-8D), was developed. This research aimed to assess the psychometric and distributional properties of the MSIS-8D compared to the EQ-5D-3L, in people with MS. Methods: Analyses were undertaken using data from the UK MS Register. Both measures were compared in terms of acceptability (missing data), distributional properties (health state frequencies, health state density curves and indices), construct validity in relation to disability, mobility, fatigue, anxiety and depression (discriminative and convergent validity, using ANOVA, independent t-tests and Spearman correlations), and responsiveness to symptom onset and relapse (mean change scores, standardised response means, standardised effect sizes, paired t-tests). Results: The MSIS-8D exhibited superior distributional properties, while the EQ-5D-3L showed greater acceptability. Both measures demonstrated excellent construct validity. Neither measure appeared responsive to symptom onset, and only the MSIS-8D met all criteria for responsiveness when people moved from a non-relapse to a relapse state. Conclusion: Although the MSIS-8D appears to offer superior distributional properties and responsiveness compared to the EQ-5D-3L, the responsiveness of both measures in this analysis was limited. This adds weight to existing concerns about the ability of utility measures used in healthcare decision-making to fully capture treatment effects in MS. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de EQ-5D Other Economic evaluation Other Health-related quality of life Other Multiple sclerosis Other Preference-based measures Other Psychometrics Other Michalowsky, Bernhard P:(DE-2719)2810763 1 Middleton, Rod 0000-0002-2130-4420 2 Hawton, Annie 0000-0002-1336-5899 3 10.1007/s11136-026-04229-5 Vol. 35, no. 5, p. 124 PERI:(DE-600)2008960-0 5 124 Quality of life research 35 2026 0962-9343 http://pub.dzne.de/record/285816/files/DZNE-2026-00352.pdf Restricted http://pub.dzne.de/record/285816/files/DZNE-2026-00352.pdf?subformat=pdfa pdfa Restricted Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2810763 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 National-Konsortium StatID:(DE-HGF)0430 StatID 2024-12-18 ger DEAL Springer StatID:(DE-HGF)3002 StatID 2024-12-18 ger DEAL Springer StatID:(DE-HGF)3002 StatID 2024-12-18 ger JCR StatID:(DE-HGF)0100 StatID QUAL LIFE RES : 2022 2024-12-18 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2024-12-18 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2024-12-18 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2024-12-18 Peer Review StatID:(DE-HGF)0030 StatID ASC 2024-12-18 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2024-12-18 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2024-12-18 DBCoverage StatID:(DE-HGF)1180 StatID Current Contents - Social and Behavioral Sciences 2024-12-18 DBCoverage StatID:(DE-HGF)0130 StatID Social Sciences Citation Index 2024-12-18 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2024-12-18 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2024-12-18 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2024-12-18 IF < 5 StatID:(DE-HGF)9900 StatID 2024-12-18 I:(DE-2719)5000067 AG Michalowsky Patient-Reported Outcomes and Health Economics Research 0 journal EDITORS VDBINPRINT I:(DE-2719)5000067 UNRESTRICTED