17 Löwen, Daniel Pracht, Eberhard D Veldmann, Marten Gras, Vincent Mauconduit, Franck Boulant, Nicolas Stöcker, Tony AG Stöcker Magnetic resonance in medicine Magnetic resonance in medicine Wiley-Liss New York, NY [u.a.] 1522-2594 10.1002/mrm.70266 English 3104 - 3115 6 95 Extend the universal pulse GRAPE formalism to pulses with a defined spectral response, and apply the concept to spatial selection.We added Bloch simulations at several frequencies for each voxel to the pulse calculation to create universal spectrally-selective GRAPE pulses. With a superimposed constant gradient field spatial selection was achieved. The method was tested in slice- and slab-selective imaging experiments.Universal spatially-selective GRAPE pulses increased FA homogeneity and SNR. In 2D gradient echoes, the SNR could be increased by approximately 6% compared to CP pulses, and in a slab-selective TSE sequence, the SNR increased by 29% against k T -spokes pulses. Additionally, the slab-selective GRAPE pulse proved to be more robust against B 0 deviations and is significantly shorter in comparison to k T -spokes pulses while maintaining a similar FA homogeneity.Spatially-selective universal GRAPE pulses exhibit superior performance compared to k T -spokes pulses. These short and robust pTx pulses hold potential for enhancing a wide range of imaging applications, thereby advancing 7T MRI technology closer to clinical use. PUB:(DE-HGF)16, ; 0, ; Phantoms, Imaging Humans Algorithms Magnetic Resonance Imaging: methods Signal-To-Noise Ratio Calibration Image Processing, Computer-Assisted: methods Computer Simulation Brain: diagnostic imaging GRAPE parallel transmission ultra‐high field universal pulses Journal Article 2026 DZNE-2026-00360 2026 pmc:PMC13049268 pmid:41588662 https://pub.dzne.de/record/285914 https://doi.org/10.1002/mrm.70266