285915 20260407160218.0 10.1016/j.neurot.2026.e00864 doi pmid:41764014 pmid pmc:PMC12993401 pmc 1933-7213 ISSN 1545-5343 ISSN 1545-5351 ISSN 1878-7479 ISSN DZNE-2026-00361 English 610 Liu, Jinlong 0 Functional network reorganization following VIM-MRgFUS for essential tremor. [Amsterdam] 2026 Elsevier B.V. article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1775570369_6691 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Magnetic resonance-guided focused ultrasound (MRgFUS) is a promising, noninvasive therapeutic approach for essential tremor (ET), yet the effects of the respective lesions on functional brain network organization remain poorly understood. Here, we performed graph theory analysis to investigate changes in small-world properties and modular architecture in ET patients six months after unilateral MRgFUS of the thalamic ventral intermediate (VIM) nucleus. Small-worldness and normalized clustering coefficient increased significantly after MRgFUS, while clustering coefficient, characteristic path length, normalized characteristic path length, global efficiency, and local efficiency remained unchanged. Modular organization was largely preserved, but trend-level enhancements in inter-modular connectivity were observed between frontoparietal and subcortical modules, as well as between frontoparietal and frontotemporal-parietal modules. Within these modules, betweenness centrality increased significantly in specific cortical hubs, including the left superior frontal gyrus, right superior parietal lobule, and left postcentral gyrus. These findings indicate that unilateral VIM-MRgFUS induces selective functional network reorganization, particularly affecting relative clustering and nodal centrality patterns. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Brain networks Other Essential tremor Other Graph theory analysis Other MRgFUS Other Ventral intermediate nucleus Other Humans MeSH Essential Tremor: diagnostic imaging MeSH Essential Tremor: therapy MeSH Essential Tremor: physiopathology MeSH Essential Tremor: surgery MeSH Male MeSH Female MeSH Magnetic Resonance Imaging: methods MeSH Middle Aged MeSH Aged MeSH Ventral Thalamic Nuclei: diagnostic imaging MeSH Ventral Thalamic Nuclei: surgery MeSH Nerve Net: diagnostic imaging MeSH Krauss, Jonas P:(DE-HGF)0 1 Purrer, Veronika P:(DE-2719)9000867 2 dzne Borger, Valeri 3 Essler, Markus 4 Radbruch, Alexander P:(DE-2719)9001861 5 dzne Wüllner, Ullrich P:(DE-2719)2000056 6 dzne Upadhyay, Neeraj P:(DE-2719)2812558 7 dzne Boecker, Henning P:(DE-2719)2810726 8 Last author dzne 10.1016/j.neurot.2026.e00864 Vol. 23, no. 2, p. e00864 - PERI:(DE-600)2279496-7 2 e00864 Neurotherapeutics 23 2026 1933-7213 http://pub.dzne.de/record/285915/files/DZNE-2026-00361.pdf Restricted http://pub.dzne.de/record/285915/files/DZNE-2026-00361.pdf?subformat=pdfa pdfa Restricted Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-HGF)0 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)9000867 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)9001861 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)2000056 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)2812558 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 8 P:(DE-2719)2810726 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DEAL Springer StatID:(DE-HGF)3002 StatID 2025-11-06 ger DEAL Springer StatID:(DE-HGF)3002 StatID 2025-11-06 ger DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2025-11-06 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-11-06 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2025-11-06 JCR StatID:(DE-HGF)0100 StatID NEUROTHERAPEUTICS : 2022 2025-11-06 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2025-04-16T07:50:47Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2025-04-16T07:50:47Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Anonymous peer review 2025-04-16T07:50:47Z DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2025-11-06 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2025-11-06 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2025-11-06 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2025-11-06 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2025-11-06 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2025-11-06 IF >= 5 StatID:(DE-HGF)9905 StatID NEUROTHERAPEUTICS : 2022 2025-11-06 Article Processing Charges StatID:(DE-HGF)0561 StatID 2025-11-06 Fees StatID:(DE-HGF)0700 StatID 2025-11-06 I:(DE-2719)1011202 AG Boecker Positron Emissions Tomography (PET) 0 I:(DE-2719)1011001 Clinical Research (Bonn) Clinical Research Coordination 1 I:(DE-2719)5000075 AG Radbruch Clinical Neuroimaging 2 I:(DE-2719)1011302 AG Wüllner Biomarker Parkinson's Disease 3 I:(DE-2719)1011101 Patient Studies (Bonn) Patient Studies (Bonn) 4 journal EDITORS VDBINPRINT I:(DE-2719)1011202 I:(DE-2719)1011001 I:(DE-2719)5000075 I:(DE-2719)1011302 I:(DE-2719)1011101 UNRESTRICTED