285920 20260408132829.0 10.1162/IMAG.a.1196 doi DZNE-2026-00366 610 Kransberg, Jonas 0000-0001-9770-8360 0 Failure to detect entorhinal grid-like signals in a passive navigation human fMRI study Cambridge, MA 2026 MIT Press article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1775647588_23151 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Grid cells in the human entorhinal cortex (EC) play a critical role in spatial navigation and memory. The EC is also one of the first regions affected by ageing and Alzheimer’s disease. This pre-registered functional magnetic resonance imaging (fMRI) study aimed to detect grid-cell-like signals (GLS) in a passive virtual navigation task. Contrary to our hypotheses and previous findings, we did not observe significant GLS at a population level, even in younger participants. Further exploratory analyses investigated the impact of task-engagement, as inferred from object-location memory performance, and showed no relationship with GLS magnitude. We also examined potential influences of a confounding one-fold directional signal and various data-processing choices but observed no consistent patterns. Our findings, consistent with recent null results from similar studies, suggest that passive navigation paradigms may be insufficient for reliably eliciting grid-like signals in human fMRI. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, Journals: pub.dzne.de Sjøli Bråthen, Anne Cecilie 0000-0002-5118-0000 1 Falch, Emilie Sogn 0009-0000-0813-4394 2 Øverbye, Knut E. Ø. 0000-0003-0809-960X 3 Garrido, Pablo F. 0000-0002-6005-7178 4 Fjell, Anders M. 0000-0003-2502-8774 5 Stangl, Matthias P:(DE-2719)2810620 6 Wolbers, Thomas P:(DE-2719)2810583 7 Sneve, Markus H. 0000-0001-7644-7915 8 Walhovd, Kristine B. 0000-0003-1918-1123 9 10.1162/IMAG.a.1196 Vol. 4, p. IMAG.a.1196 PERI:(DE-600)3167925-0 IMAG.a.1196 Imaging neuroscience 4 2026 2837-6056 http://pub.dzne.de/record/285920/files/DZNE-2026-00366.pdf Restricted http://pub.dzne.de/record/285920/files/DZNE-2026-00366.pdf?subformat=pdfa pdfa Restricted Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)2810583 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2025-11-05 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-11-05 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2025-11-05 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2024-09-26T09:40:26Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2024-09-26T09:40:26Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Anonymous peer review 2024-09-26T09:40:26Z Creative Commons Attribution CC BY (No Version) LIC:(DE-HGF)CCBYNV V:(DE-HGF) DOAJ 2024-09-26T09:40:26Z DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2025-11-05 WoS StatID:(DE-HGF)0112 StatID Emerging Sources Citation Index 2025-11-05 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2025-11-05 Article Processing Charges StatID:(DE-HGF)0561 StatID 2025-11-05 Fees StatID:(DE-HGF)0700 StatID 2025-11-05 I:(DE-2719)1310002 AG Wolbers Aging, Cognition and Technology 0 journal EDITORS VDBINPRINT I:(DE-2719)1310002 UNRESTRICTED