286086 20260413113805.0 10.14814/phy2.70845 doi pmid:41954020 pmid pmc:PMC13062934 pmc DZNE-2026-00382 English 610 Streckfuss-Bömeke, Katrin 0000-0001-5137-7228 0 Models of the human heart for biomedical research: Opportunities and challenges. [Erscheinungsort nicht ermittelbar] 2026 Wiley article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1776073044_12975 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Model systems that mimic human cardiac structure and function are essential for the development of novel diagnostics and effective treatments for cardiovascular diseases. While non-human vertebrate models, from zebrafish to pig, remain vital to cardiovascular research, the translatability of findings to human patients is often limited. Therefore, animal experiments should be supplemented with human model systems, including human induced pluripotent stem cell-derived cells, 3D engineered constructs, and last but not least, native tissue preparations and isolated primary cardiomyocytes. However, while human myocardium remains the gold standard, human heart tissue - and particularly tissue from control hearts-remains scarce, and its use in research is generally restricted to settings where tissue has been excised from diseased or failing hearts. While it is in principle possible to use tissue from rejected non-failing donor hearts that cannot be transplanted, legal hurdles (e.g., in Germany) can restrict the use of non-transplanted donor organs in research. Given the challenges associated with accessing and using human tissue in biomedical research, an integrated strategy towards combining non-human vertebrate models, in silico models, and human tissue-derived models is recommended, enhancing the chances of successful research and development, and helping bridge the gap between preclinical and clinical research. 352 - Disease Mechanisms (POF4-352) G:(DE-HGF)POF4-352 POF4-352 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de animal models Other donor tissue Other human myocardium Other stem cell models Other vertebrate models Other Humans MeSH Biomedical Research: methods MeSH Animals MeSH Heart: physiology MeSH Myocytes, Cardiac MeSH Induced Pluripotent Stem Cells MeSH Zelarayán, Laura C 0000-0002-9001-0346 1 Schnabel, Renate B 0000-0001-7170-9509 2 Kränkel, Nicolle 0000-0002-9363-1770 3 Maack, Christoph 0000-0003-3694-4559 4 Eschenhagen, Thomas 0000-0003-1750-1170 5 Kappler, Hannah E 0000-0002-8615-6561 6 Klingmüller, Ursula 0000-0001-9845-3099 7 Kramann, Rafael 0000-0003-4048-6351 8 Loewe, Axel 0000-0002-2487-4744 9 Milting, Hendrik 0000-0001-9722-0007 10 Molina, Cristina E 0000-0003-3094-1568 11 Panáková, Daniela 0000-0002-8739-6225 12 Podesser, Bruno K 0000-0002-4641-7202 13 Schnieke, Angelika 0000-0002-5761-9635 14 Schröder, Katrin 0000-0002-3099-526X 15 Seidel, Thomas 0000-0002-3127-1693 16 Sossalla, Samuel 0000-0001-8034-2673 17 Zgierski-Johnston, Callum 0000-0002-6773-9884 18 Zimmermann, Wolfram-Hubertus P:(DE-2719)9001434 19 Rog-Zielinska, Eva A 0000-0002-3295-4728 20 Kohl, Peter 0000-0003-0416-6270 21 10.14814/phy2.70845 Vol. 14, no. 7, p. e70845 PERI:(DE-600)2724325-4 7 e70845 Physiological reports 14 2026 2051-817X http://pub.dzne.de/record/286086/files/DZNE-2026-00382.pdf Restricted http://pub.dzne.de/record/286086/files/DZNE-2026-00382.pdf?subformat=pdfa pdfa Restricted Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 19 P:(DE-2719)9001434 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-352 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Disease Mechanisms 0 2026 DEAL Wiley StatID:(DE-HGF)3001 StatID 2024-12-05 ger JCR StatID:(DE-HGF)0100 StatID PHYSIOL REP : 2022 2024-12-05 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2024-12-05 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2024-12-05 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2024-08-08T17:09:21Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2024-08-08T17:09:21Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Peer review 2024-08-08T17:09:21Z Creative Commons Attribution CC BY (No Version) LIC:(DE-HGF)CCBYNV V:(DE-HGF) DOAJ 2024-08-08T17:09:21Z DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2024-12-05 Peer Review StatID:(DE-HGF)0030 StatID ASC 2024-12-05 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2024-12-05 WoS StatID:(DE-HGF)0112 StatID Emerging Sources Citation Index 2024-12-05 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2024-12-05 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2024-12-05 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2024-12-05 IF < 5 StatID:(DE-HGF)9900 StatID 2024-12-05 Article Processing Charges StatID:(DE-HGF)0561 StatID 2024-12-05 Fees StatID:(DE-HGF)0700 StatID 2024-12-05 I:(DE-2719)1410002 AG Fischer Epigenetics and Systems Medicine in Neurodegenerative Diseases 0 journal EDITORS VDBINPRINT I:(DE-2719)1410002 UNRESTRICTED