286087 20260413113902.0 10.1038/s41598-026-42430-1 doi pmid:41776314 pmid pmc:PMC13066363 pmc DZNE-2026-00383 English 600 Nager, Ladina 0 Sleep is associated with posttraumatic stress symptom severity in patients with an implantable cardioverter-defibrillator depending on age. [London] 2026 Springer Nature article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1776073069_13395 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Patients with implantable cardioverter-defibrillators (ICDs) are vulnerable to psychological distress, including posttraumatic stress disorder (PTSD). Impaired sleep is a hallmark of PTSD, and may also act as a risk factor that maintains or exacerbates PTSD, yet this relationship has not been examined in ICD recipients across different ages. We assessed 422 patients with ICD or cardiac resynchronisation therapy with defibrillator (CRT-D) who completed the Pittsburgh sleep quality index (PSQI) and post-traumatic diagnostic scale (PDS). 44.2% of patients showed impaired sleep (PSQI > 5). A multiple linear regression model showed that poorer sleep was associated with greater PTSD severity, and this association weakened with increasing age (interaction β = - 0.002, 95% CI [- 0.004, - 0.001], p = 0.008), indicating stronger effects in younger patients. Exploratory component analyses identified daytime dysfunction (β = 0.351, 95% CI [0.212, 0.490], p < 0.001) and sleep disturbance (β = 0.345, 95% CI [0.126, 0.564], p = 0.002) as the components most strongly linked to PTSD symptoms. These findings support that routine sleep screening is an important component of comprehensive ICD care, identifying clinically relevant sleep disturbance associated with PTSD symptom severity and underscoring sleep as a meaningful and modifiable treatment target. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Age Other Implantable cardioverter-defibrillator (ICD) Other Pittsburgh sleep quality index (PSQI) Other Posttraumatic stress disorder (PTSD) Other Sleep Other Humans MeSH Stress Disorders, Post-Traumatic: etiology MeSH Stress Disorders, Post-Traumatic: physiopathology MeSH Defibrillators, Implantable: psychology MeSH Defibrillators, Implantable: adverse effects MeSH Male MeSH Female MeSH Middle Aged MeSH Aged MeSH Sleep Wake Disorders MeSH Severity of Illness Index MeSH Age Factors MeSH Sleep: physiology MeSH Adult MeSH Risk Factors MeSH Sleep Quality MeSH Princip, Mary 1 Attanasio, Veronica 2 Dörner, Marc P:(DE-2719)9002951 3 dzne Guth, Lisa 4 Zirngast, Sina 5 Sila, Rahel 6 Pazhenkottil, Aju P 7 Menzi, Anna 8 König, Noelle 9 Zuccarella-Hackl, Claudia 10 von Känel, Roland 11 10.1038/s41598-026-42430-1 Vol. 16, no. 1, p. 11869 PERI:(DE-600)2615211-3 1 11869 Scientific reports 16 2026 2045-2322 http://pub.dzne.de/record/286087/files/DZNE-2026-00383.pdf Restricted http://pub.dzne.de/record/286087/files/DZNE-2026-00383.pdf?subformat=pdfa pdfa Restricted Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)9002951 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 JCR StatID:(DE-HGF)0100 StatID SCI REP-UK : 2022 2025-11-07 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2025-11-07 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-11-07 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2025-11-07 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2025-08-21T14:09:21Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2025-08-21T14:09:21Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Anonymous peer review 2025-08-21T14:09:21Z DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2025-11-07 Peer Review StatID:(DE-HGF)0030 StatID ASC 2025-11-07 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2025-11-07 DBCoverage StatID:(DE-HGF)1150 StatID Current Contents - Physical, Chemical and Earth Sciences 2025-11-07 DBCoverage StatID:(DE-HGF)1190 StatID Biological Abstracts 2025-11-07 DBCoverage StatID:(DE-HGF)1040 StatID Zoological Record 2025-11-07 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2025-11-07 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2025-11-07 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2025-11-07 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2025-11-07 IF < 5 StatID:(DE-HGF)9900 StatID 2025-11-07 Article Processing Charges StatID:(DE-HGF)0561 StatID 2025-11-07 Fees StatID:(DE-HGF)0700 StatID 2025-11-07 I:(DE-2719)1310010 AG Schreiber Mixed Cerebral Pathologies and Cognitive Aging 0 journal EDITORS VDBINPRINT I:(DE-2719)1310010 UNRESTRICTED