286091 20260413130401.0 10.1016/j.tjpad.2026.100556 doi pmid:41935406 pmid 2274-5807 ISSN 2426-0266 ISSN DZNE-2026-00387 English 610 Sannemann, Lena 0 Dementia risk factor assessment in a local Alzheimer's prevention population: a German cross-sectional, observational study. [Paris] 2026 Elsevier Masson SAS article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1776077933_32198 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The risk for dementia is to a significant extent driven by potentially modifiable factors. Prevention strategies are increasingly aiming at individually tailored risk reduction approaches, particularly in light of emerging Brain Health Services for dementia prevention (dBHS).The cross-sectional observational study 'Individual Risk Profiling for Alzheimer's and Dementia Prevention' (INSPIRATION) assessed the individual risk factors of 162 participants of the local Cologne Alzheimer Prevention Registry and provided individual feedback on risk profiles during a single visit. We analysed the frequency and patterns of risk factors and explored their association with cognition and Alzheimer's disease (AD) plasma biomarkers.The most common risk factors in this population were obesity, non-adherence to a Mediterranean diet, low subjective sleep quality, subjective experience of stress, and hearing impairment. A principal component analysis (PCA) revealed six principal components (PC), which we labeled as (1) psychosocial factors, (2) blood pressure, (3) physical condition, (4) hearing impairment, (5) lifestyle, and (6) substance use. We found isolated associations between PCs, cognition, and AD plasma biomarkers.These findings provide initial insights into which risk factors may be most relevant and actionable for highly-educated and prevention-motivated populations likely to seek dBHS. Interventions addressing the domains of psychosocial factors, physical condition, and lifestyle may be particularly relevant to consider for a personally tailored risk reduction approach in comparable populations.The study was funded by research funds of the Medical Faculty and the University Hospital Cologne, University of Cologne and the non-profit association Kölner Verein für seelische Gesundheit e.V. 353 - Clinical and Health Care Research (POF4-353) G:(DE-HGF)POF4-353 POF4-353 POF IV 0 Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de Alzheimer’s disease Other Dementia Other Modifiable risk factors Other Prevention Other Risk assessment Other Risk communication Other Gerards, Michelle P:(DE-2719)9003021 1 dzne Bohr, Lara 2 Brosseron, Frederic P:(DE-2719)2810593 3 dzne Escher, Claus P:(DE-2719)9002022 4 dzne Kalthegener, Franziska 5 Müller, Theresa 6 Ramírez, Alfredo P:(DE-2719)2812825 7 dzne Zeyen, Philip 8 Jessen, Frank P:(DE-2719)2000032 9 dzne Rostamzadeh, Ayda 10 10.1016/j.tjpad.2026.100556 Vol. 13, no. 6, p. 100556 - PERI:(DE-600)2782183-3 6 100556 The journal of prevention of Alzheimer's disease 13 2026 2274-5807 http://pub.dzne.de/record/286091/files/DZNE-2026-00387.pdf Restricted http://pub.dzne.de/record/286091/files/DZNE-2026-00387.pdf?subformat=pdfa pdfa Restricted External Institute I:(DE-HGF)0 Extern 1 P:(DE-2719)9003021 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2810593 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)9002022 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)2812825 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 9 P:(DE-2719)2000032 DE-HGF Gesundheit Neurodegenerative Diseases G:(DE-HGF)POF4-350 G:(DE-HGF)POF4-353 G:(DE-HGF)POF4 G:(DE-HGF)POF4-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DEAL Springer StatID:(DE-HGF)3002 StatID 2025-11-11 ger DEAL Springer StatID:(DE-HGF)3002 StatID 2025-11-11 ger JCR StatID:(DE-HGF)0100 StatID JPAD-J PREV ALZHEIM : 2022 2025-11-11 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2025-11-11 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2025-11-11 DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central 2025-11-11 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2025-11-11 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2025-11-11 DBCoverage StatID:(DE-HGF)0160 StatID Essential Science Indicators 2025-11-11 WoS StatID:(DE-HGF)0113 StatID Science Citation Index Expanded 2025-11-11 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2025-11-11 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2025-05-28T09:11:42Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2025-05-28T09:11:42Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Anonymous peer review 2025-05-28T09:11:42Z IF >= 5 StatID:(DE-HGF)9905 StatID JPAD-J PREV ALZHEIM : 2022 2025-11-11 Article Processing Charges StatID:(DE-HGF)0561 StatID 2025-11-11 Fees StatID:(DE-HGF)0700 StatID 2025-11-11 I:(DE-2719)1011303 AG Heneka Neuroinflammation, Biomarker 0 I:(DE-2719)1011102 AG Jessen Clinical Alzheimer’s Disease Research 1 I:(DE-2719)1011001 Clinical Research (Bonn) Clinical Research Coordination 2 I:(DE-2719)1011101 Patient Studies (Bonn) Patient Studies (Bonn) 3 journal EDITORS VDBINPRINT I:(DE-2719)1011303 I:(DE-2719)1011102 I:(DE-2719)1011001 I:(DE-2719)1011101 UNRESTRICTED