17 Chatterjee, Soumick Yassin, Hadya Dubost, Florian Nürnberger, Andreas Speck, Oliver AG Speck Neurocomputing Neurocomputing Elsevier Amsterdam 0925-2312 10.1016/j.neucom.2026.133460 133460 682 Deep learning has demonstrated significant potential in medical imaging; however, the opacity of “black-box” models hinders clinical trust, while segmentation tasks typically necessitate laborious, hard-to-obtain pixel-wise annotations. To address these challenges simultaneously, this paper introduces a framework for three inherently explainable classifiers (GP-UNet, GP-ShuffleUNet, and GP-ReconResNet). By integrating a global pooling mechanism, these networks generate localisation heatmaps that directly influence classification decisions, offering inherent interpretability without relying on potentially unreliable post-hoc methods. These heatmaps are subsequently thresholded to achieve weakly-supervised segmentation, requiring only image-level classification labels for training. Validated on two datasets for multi-class brain tumour classification, the proposed models achieved a peak F1-score of 0.93. For the weakly-supervised segmentation task, a median Dice score of 0.728 (95% CI: 0.715–0.739) was recorded. Notably, on a subset of tumour-only images, the best model achieved an accuracy of 98.7%, outperforming state-of-the-art glioma grading binary classifiers. Furthermore, comparative Precision-Recall analysis validated the framework’s robustness against severe class imbalance, establishing a direct correlation between diagnostic confidence and segmentation fidelity. These results demonstrate that the proposed framework successfully combines high diagnostic accuracy with essential transparency, offering a promising direction for trustworthy clinical decision support. PUB:(DE-HGF)16, ; 0, ; Journal Article 2026 DZNE-2026-00388 2026 https://pub.dzne.de/record/286092 https://doi.org/10.1016/j.neucom.2026.133460