Contribution to a book

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2022-12-05
15:08
[DZNE-2022-01748] Contribution to a book
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Light Microscopy and Dynamic Light Scattering to Study Liquid-Liquid Phase Separation of Tau Proteins In Vitro.
Protein Aggregation / Cieplak, Andrzej Stanisław (Editor) ; New York, NY : Springer US, 2023, Chapter 15 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-2596-5=978-1-0716-2597-2 ; doi:10.1007/978-1-0716-2597-2 New York, NY : Springer US, Methods in Molecular Biology 2551, 225 - 243 () [10.1007/978-1-0716-2597-2_15]
Tau is an intrinsically disordered protein that binds and stabilizes axonal microtubules (MTs) in neurons of the central nervous system. The binding of Tau to MTs is mediated by its repeat domain and flanking proline-rich domains. [...]

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2022-12-05
14:19
DBCoverage [DZNE-2022-01734] Journal Article/Contribution to a conference proceedings/Contribution to a book
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A novel link prediction approach on clinical knowledge graphs utilizing graph structures
Proceedings of the of the 17th Conference on Computer Science and Intelligence Systems : [Proceedings] - , 2022. - ISBN - doi:10.15439/2022F36
17th Conference on Computer Science and Intelligence Systems, Meeting location, 4 Sep 2022 - 7 Sep 20222022-09-042022-09-07
Annals of computer science and information systems 30, () [10.15439/2022F36]
This paper presents a novel approach towards link prediction in clinical knowledge graphs. They play a central role for linking data from different data sources and are widely used in big data integration, especially for connecting data from different domains. [...]

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2022-12-05
11:33
[DZNE-2022-01728] Contribution to a conference proceedings/Contribution to a book
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Large-scale Multimodal Recordings on a High-density Neurochip: Olfactory Bulb and Hippocampal Networks.
2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) : [Proceedings] - IEEE, 2022. - ISBN 978-1-7281-2782-8 - doi:10.1109/EMBC48229.2022.9871961
2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), GlasgowGlasgow, Scotland, 11 Jul 2022 - 15 Jul 20222022-07-112022-07-15
IEEE 2022, 3111-3114 () [10.1109/EMBC48229.2022.9871961]
A striking example of the brain's complexity and continued plasticity is the addition of new neuronal components to a circuit in a process called neurogenesis. Two brain regions exhibit profound circuit remodeling through this process - the olfactory bulb and hippocampus. [...]

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2022-12-02
12:19
[DZNE-2022-01712] Contribution to a book
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Parkinson disease and other synucleinopathies
Neurobiology of Brain Disorders / Gasser, Thomas ; : Elsevier, 2023, ; ISBN: 9780323856546 ; doi:10.1016/B978-0-323-85654-6.00015-0 Elsevier 253-274 () [10.1016/B978-0-323-85654-6.00015-0]
Parkinson disease (PD) is a heterogeneous and progressive neurodegenerative disorder. PD was traditionally defined as a movement disorder resulting from loss of dopamine in the basal ganglia, but its pathology is now known to be more widespread, involving both the central and peripheral nervous system, and leading to various motor and nonmotor signs and symptoms. [...]

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2022-12-02
12:11
[DZNE-2022-01709] Contribution to a book
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Verification of Protein Changes Determined by 2D-DIGE Based Proteomics Using Immunofluorescence Microscopy.
Difference Gel Electrophoresis / Ohlendieck, Kay (Editor) ; New York, NY : Springer US, 2023, Chapter 30 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-2830-0=978-1-0716-2831-7 ; doi:10.1007/978-1-0716-2831-7 New York, NY : Springer US, Methods in Molecular Biology 2596, 445 - 464 () [10.1007/978-1-0716-2831-7_30]
Fluorescence two-dimensional difference gel electrophoresis (2D-DIGE) is a key biochemical method for the comparative analysis of complex protein mixtures. The technique focuses on the identification and characterization of individual protein species following gel electrophoretic separation making it an important analytical tool of top-down proteomics. [...]

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2022-12-02
12:09
[DZNE-2022-01708] Contribution to a book
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Three-Dimensional Biohybrid StarPEG-Heparin Hydrogel Cultures for Modeling Human Neuronal Development and Alzheimer's Disease Pathology.
Alzheimer’s Disease / Chun, Jerold (Editor) ; New York, NY : Springer US, 2023, Chapter 8 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-2654-2=978-1-0716-2655-9 ; doi:10.1007/978-1-0716-2655-9 New York, NY : Springer US, Methods in Molecular Biology 2561, 159 - 170 () [10.1007/978-1-0716-2655-9_8]
In this chapter, we present the methodology currently used in our laboratory to generate a starPEG-MMP (starPEG)- and heparin maleimide HM06 (heparin)-based 3D cell culture system, in a hydrogel, that can be used to study human neuronal development and Alzheimer's disease (AD) pathology. A 3D cell culture system can mimic the in vivo cellular environment better than a 2D format, in which these cells exhibit neural network formation, electrophysiological activity, tissue-specific extracellular matrix (ECM) deposition, and neurotransmitter responsiveness. [...]

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2022-12-02
12:06
[DZNE-2022-01707] Contribution to a book
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Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer's Disease.
Protein Aggregation / Cieplak, Andrzej Stanisław (Editor) ; New York, NY : Springer US, 2023, Chapter 9 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-2596-5=978-1-0716-2597-2 ; doi:10.1007/978-1-0716-2597-2 New York, NY : Springer US, Methods in Molecular Biology 2551, 111 - 123 () [10.1007/978-1-0716-2597-2_9]
Tau is a microtubule-associated protein found mainly in the axons of neurons in the brain. Abnormal changes in Tau (e.g., aggregation, hyperphosphorylation) are hallmarks of Alzheimer's disease. [...]

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2022-12-02
12:03
[DZNE-2022-01706] Contribution to a book
; ; ; et al
Analysis of Tau/Nucleoporin Interactions by Surface Plasmon Resonance Spectroscopy.
Protein Aggregation / Cieplak, Andrzej Stanisław (Editor) ; New York, NY : Springer US, 2023, Chapter 8 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-2596-5=978-1-0716-2597-2 ; doi:10.1007/978-1-0716-2597-2 New York, NY : Springer US, Methods in Molecular Biology 2551, 95 - 109 () [10.1007/978-1-0716-2597-2_8]
Tau, a soluble and predominantly neuronal protein, is best known for its microtubule (MT)-binding function in the cytosol, where it decisively contributes to stability as well as modulation of MT dynamics. In Alzheimer's disease and other tauopathies, Tau is altered into forming intracellular neurofibrillary tangles; additionally, also a mislocalization from the cytosol to the nucleus has been observed where interactions of Tau with the nucleus become possible. [...]

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2022-10-11
17:09
OpenAccess [DZNE-2022-01580] Contribution to a conference proceedings/Contribution to a book
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Collaborative Wayfinding Under Distributed Spatial Knowledge (Short Paper)
LIPIcs, Vol. 240, 15th International Conference on Spatial Information Theory (COSIT 2022), pages 25:1-25:10
15th International Conference on Spatial Information Theory (COSIT 2022)., Meeting location,
Schloss Dagstuhl - Leibniz-Zentrum für Informatik 240, 25:1-25:10 () [10.4230/LIPIcs.COSIT.2022.25]
In many everyday situations, two or more people navigate collaboratively but their spatial knowledge does not necessarily overlap. However, most research to date, has investigated social wayfinding under either 1-sided or fully shared spatial information. [...]
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2022-10-10
15:15
[DZNE-2022-01542] Contribution to a book
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Allergy and autoimmunity: Share of genetics and environment
Translational Autoimmunity / Manibarathi, Kalaivani ; : Elsevier, 2022, ; ISBN: 9780323854153 ; doi:10.1016/B978-0-323-85415-3.00016-7 Elsevier, Translational Immunology 3, 231-260 () [10.1016/B978-0-323-85415-3.00016-7]
Allergy and autoimmune diseases generate from the dysfunction of the immune system. According to the conventional dogma, both these immunological disorders generate from diverse pathways. [...]

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