2024-03-04 09:32 |
[DZNE-2024-00238]
Contribution to a book
Perneczky, R. ; Hansen, N. ; Hofmann, A. ; et al
Blood-Based Biomarkers for Early Alzheimer's Disease Diagnosis in Real-World Settings.
2024Biomarkers for Alzheimer’s Disease Drug Development / Perneczky, Robert (Editor) ; New York, NY : Springer US, 2024, Chapter 1 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-3773-9=978-1-0716-3774-6 ; doi:10.1007/978-1-0716-3774-6
New York, NY : Springer US, Methods in Molecular Biology 2785, 3 - 14 (2024) [10.1007/978-1-0716-3774-6_1]2024
As our knowledge about the biology of Alzheimer's disease (AD) expands and we recognize the significance of early intervention for effective treatment, there is a shift in focus toward detecting the disease at an early stage. AD is characterized by the accumulation of misfolded amyloid-β (Aβ) and phosphorylated tau proteins in the brain, leading to the formation of senile plaques and neurofibrillary tangles. [...]
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2024-03-04 09:29 |
[DZNE-2024-00237]
Contribution to a book
Malpetti, M. ; Franzmeier, N. ; Brendel, M.
PET Imaging to Measure Neuroinflammation In Vivo.
2024Biomarkers for Alzheimer’s Disease Drug Development / Perneczky, Robert (Editor) ; New York, NY : Springer US, 2024, Chapter 12 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-3773-9=978-1-0716-3774-6 ; doi:10.1007/978-1-0716-3774-6
New York, NY : Springer US, Methods in Molecular Biology 2785, 177 - 193 (2024) [10.1007/978-1-0716-3774-6_12]2024
This paper provides an overview of the role of neuroinflammation in Alzheimer's disease and other neurodegenerative diseases, highlighting the potential of anti-inflammatory treatments to slow or prevent decline. This research focuses on the use of positron emission tomography (PET) imaging to visualize and quantify molecular brain changes in patients, specifically microglial activation and reactive astrogliosis. [...]
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2024-03-04 09:23 |
[DZNE-2024-00236]
Contribution to a book
Perneczky, R. ; Ersözlü, E. ; Rauchmann, B.-S.
Analysis of Resting-State Functional Magnetic Resonance Imaging in Alzheimer’s Disease
2024Biomarkers for Alzheimer’s Disease Drug Development / Perneczky, Robert (Editor) ; New York, NY : Springer US, 2024, Chapter 7 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-3773-9=978-1-0716-3774-6 ; doi:10.1007/978-1-0716-3774-6
New York, NY : Springer US, Methods in Molecular Biology 2785, 89 - 104 (2024) [10.1007/978-1-0716-3774-6_7]2024
Alzheimer’s disease (AD) has been characterized by widespread network disconnection among brain regions, widely overlapping with the hallmarks of the disease. Functional connectivity has been studied with an upward trend in the last two decades, predominantly in AD among other neuropsychiatric disorders, and presents a potential biomarker with various features that might provide unique contributions to foster our understanding of neural mechanisms of AD. [...]
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2024-03-04 09:20 |
[DZNE-2024-00235]
Contribution to a book
Perneczky, R.
Alzheimer's Disease Prevention and Treatment Based on Population-Based Approaches.
2024Biomarkers for Alzheimer’s Disease Drug Development / Perneczky, Robert (Editor) ; New York, NY : Springer US, 2024, Chapter 2 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-3773-9=978-1-0716-3774-6 ; doi:10.1007/978-1-0716-3774-6
New York, NY : Springer US, Methods in Molecular Biology 2785, 15 - 33 (2024) [10.1007/978-1-0716-3774-6_2]2024
The development of effective prevention and treatment strategies for Alzheimer's disease (AD) and dementia is hindered by limited knowledge of the underlying biological and environmental causes. While certain genetic factors have been associated with AD, and various lifestyle and environmental factors have been linked to dementia risk, the interactions between genes and the environment are not yet fully understood. [...]
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2024-01-22 13:51 |
[DZNE-2024-00089]
Contribution to a conference proceedings/Contribution to a book
Betz, P. K. ; Stoll, J. ; Grappendorf, V. ; et al
ESID: Exploring the Design and Development of a Visual Analytics Tool for Epidemiological Emergencies
20232023 IEEE VIS Workshop on Visualization for Pandemic and Emergency Responses (Vis4PandEmRes) : [Proceedings] - IEEE, 2023. - ISBN 979-8-3503-3026-7 - doi:10.1109/Vis4PandEmRes60343.2023.00007 2023 IEEE VIS Workshop on Visualization for Pandemic and Emergency Responses (Vis4PandEmRes), MelbourneMelbourne, Australia, 22 Oct 2023 - 23 Oct 20232023-10-222023-10-23
IEEE 8 - 14 (2023) [10.1109/Vis4PandEmRes60343.2023.00007]2023
Visual analytics tools can help illustrate the spread of infectious diseases and enable informed decisions on epidemiological and public health issues. To create visualisation tools that are intuitive, easy to use, and effective in communicating information, continued research and development focusing on user-centric and methodological design models is extremely important. [...]
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2023-12-18 10:56 |
[DZNE-2023-01148]
Contribution to a book
Stöcker, T.
Recommendations for neuro MRI acquisition strategies
2021Advanced Neuro MR Techniques and Applications / Stöcker, Tony ; : Elsevier, 2021, ; ISSN: 26669099 ; ISBN: 9780128224793 ; doi:10.1016/B978-0-12-822479-3.00009-9
Elsevier, Advances in Magnetic Resonance Technology and Applications 4, 3 - 20 (2021) [10.1016/B978-0-12-822479-3.00009-9]2021
The field of MR neuroimaging is evolving rapidly. New, promising methods are being developed at a breathtaking speed, providing a plethora of image contrasts to investigate brain structure and function. [...]
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2023-12-18 10:55 |
[DZNE-2023-01147]
Contribution to a book
Ehses, P. ; Heule, R.
Multiproperty Mapping Methods
2020Quantitative Magnetic Resonance Imaging / Ehses, Philipp ; : Elsevier, 2020, ; ISSN: 26669099 ; ISBN: 9780128170571 ; doi:10.1016/B978-0-12-817057-1.00006-8
Elsevier, Advances in Magnetic Resonance Technology and Applications 1, 65 - 90 (2020) [10.1016/B978-0-12-817057-1.00006-8]2020
This chapter presents an incomplete overview of techniques for the joint quantification of multiple relaxometry parameters from a single experiment. The joint approach has several advantages over the sequential quantification of multiple parameters. [...]
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2023-12-18 10:53 |
[DZNE-2023-01146]
Contribution to a book
Mattern, H. ; Lüsebrink, F. ; Speck, O.
High-resolution structural brain imaging
2022Motion Correction in MR - Correction of Position, Motion, and Dynamic Field Changes / Mattern, Hendrik ; : Elsevier, 2022, ; ISSN: 26669099 ; ISBN: 9780128244609 ; doi:10.1016/B978-0-12-824460-9.00014-5
Elsevier, Advances in Magnetic Resonance Technology and Applications 6, 433 - 448 (2022) [10.1016/B978-0-12-824460-9.00014-5]2022
At high spatial resolution, unintentional motion due to breathing or slow head drifts is of the same order as the voxel size. Further, higher resolution is prolonging scan sessions, rendering subject motion more likely. [...]
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2023-12-18 10:50 |
[DZNE-2023-01145]
Contribution to a book
Grande, X. ; Wisse, L. ; Berron, D.
Ultra-high field imaging of the human medial temporal lobe
2023Ultra-High Field Neuro MRI / Grande, Xenia ; : Elsevier, 2023, ; ISSN: 26669099 ; ISBN: 9780323998987 ; doi:10.1016/B978-0-323-99898-7.00031-6
Elsevier, Advances in Magnetic Resonance Technology and Applications 10, 259 - 272 (2023) [10.1016/B978-0-323-99898-7.00031-6]2023
Ultra-high field (UHF) imaging provides substantial benefits for the structural and functional investigation of the human medial temporal lobe. The medial temporal lobe is a complex system of many subregions that is critically involved in many cognitive functions and vulnerable to neurodegenerative processes. [...]
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2023-12-18 10:48 |
[DZNE-2023-01144]
Contribution to a book
Betts, M. J. ; Perosa, V. ; Hämmerer, D. ; et al
Healthy aging and Alzheimer's disease
2023Ultra-High Field Neuro MRI / Betts, Matthew J. ; : Elsevier, 2023, ; ISSN: 26669099 ; ISBN: 9780323998987 ; doi:10.1016/B978-0-323-99898-7.00030-4
Elsevier, Advances in Magnetic Resonance Technology and Applications 10, 537 - 547 (2023) [10.1016/B978-0-323-99898-7.00030-4]2023
The recent approval of 7T clinical MRI systems by regulatory bodies in the United States and Europe has set the ground running to transition from purely research applications to research and clinical utilization. Moving toward ultra-high field (UHF) MRI opens up a number of opportunities for clinical imaging owing to the significant increase in the signal-to-noise ratio (SNR). [...]
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