Contribution to a book

This case highlights a diagnostic challenge in a 63-year-old female with mild cognitive impairment (MCI) and an arteriovenous malformation (AVM) in the right parieto-occipital brain region. While the patient exhibited minor memory deficits with preserved daily function, a tau-PET scan using [18F]PI-2620 was performed to evaluate possible underlying tauopathy. [...]

This case study reports a diagnostically complex scenario involving a 77-year-old female who initially presented with mild memory complaints. Over the course of one year, she exhibited significant cognitive decline, with MMSE scores dropping from 27/30 to 20/30. [...]

In many biomedical segmentation tasks, the preservation of elongated structure continuity and length is more important than voxel-wise accuracy. We propose two novel loss functions, Negative Centerline Loss and Simplified Topology Loss, that, applied to Convolutional Neural Networks (CNNs), help preserve connectivity of output instances. [...]

Global societies face unprecedented challenges as populations age. The ability to navigate is central to nearly all meaningful activities in which older adults participate, promoting both independence and health. [...]

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is projected to affect over 130 million people globally by 2050. While extensive efforts have focused on targeting molecular hallmarks such as amyloid-beta (Aβ) plaques and tau pathology, network-level dysfunction remains a critical but underexplored component of AD progression. [...]

Learning and memory are fundamental brain functions governed by rhythmic oscillatory activity, which synchronizes neural communication and modulates network dynamics. Distinct oscillatory patterns-theta (θ), beta (β), gamma (γ), and sharp wave-ripples (SWR)-coordinate neural ensemble activity, particularly in the hippocampal CA1-CA3 regions, where they play a crucial role in learning and memory. [...]

Unraveling the complexity of network-level synaptic plasticity remains a challenge due to the dynamic and interconnected nature of neural circuits. In this study, we employ network motifs-recurrent, functionally specialized patterns of connectivity-as a framework to dissect long-term potentiation (LTP)-induced reorganization in hippocampal CA1-CA3 networks. [...]

70 million people suffer from epilepsy worldwide with temporal lobe epilepsy (TLE) being the most common focal epilepsy in adults. The hippocampus, a region associated with TLE, is highly susceptible to pathological synchronization and epileptogenesis due to its functional and anatomical organization. [...]

Robust analysis of biosignals hinges on well-crafted processing pipelines, yet assembling them is still a slow, errorprone exercise, requiring both domain expertise and programming skills. While Large Language Models (LLMs) offer promising assistance, they fundamentally lack the combinatorial reasoning capabilities needed for designing reliable and reproducible processing pipelines. [...]