Contribution to a book

Tau is an intrinsically disordered protein that binds and stabilizes axonal microtubules (MTs) in neurons of the central nervous system. The binding of Tau to MTs is mediated by its repeat domain and flanking proline-rich domains. [...]

This paper presents a novel approach towards link prediction in clinical knowledge graphs. They play a central role for linking data from different data sources and are widely used in big data integration, especially for connecting data from different domains. [...]

A striking example of the brain's complexity and continued plasticity is the addition of new neuronal components to a circuit in a process called neurogenesis. Two brain regions exhibit profound circuit remodeling through this process - the olfactory bulb and hippocampus. [...]

Parkinson disease (PD) is a heterogeneous and progressive neurodegenerative disorder. PD was traditionally defined as a movement disorder resulting from loss of dopamine in the basal ganglia, but its pathology is now known to be more widespread, involving both the central and peripheral nervous system, and leading to various motor and nonmotor signs and symptoms. [...]

Fluorescence two-dimensional difference gel electrophoresis (2D-DIGE) is a key biochemical method for the comparative analysis of complex protein mixtures. The technique focuses on the identification and characterization of individual protein species following gel electrophoretic separation making it an important analytical tool of top-down proteomics. [...]

In this chapter, we present the methodology currently used in our laboratory to generate a starPEG-MMP (starPEG)- and heparin maleimide HM06 (heparin)-based 3D cell culture system, in a hydrogel, that can be used to study human neuronal development and Alzheimer's disease (AD) pathology. A 3D cell culture system can mimic the in vivo cellular environment better than a 2D format, in which these cells exhibit neural network formation, electrophysiological activity, tissue-specific extracellular matrix (ECM) deposition, and neurotransmitter responsiveness. [...]

Tau is a microtubule-associated protein found mainly in the axons of neurons in the brain. Abnormal changes in Tau (e.g., aggregation, hyperphosphorylation) are hallmarks of Alzheimer's disease. [...]

Tau, a soluble and predominantly neuronal protein, is best known for its microtubule (MT)-binding function in the cytosol, where it decisively contributes to stability as well as modulation of MT dynamics. In Alzheimer's disease and other tauopathies, Tau is altered into forming intracellular neurofibrillary tangles; additionally, also a mislocalization from the cytosol to the nucleus has been observed where interactions of Tau with the nucleus become possible. [...]

In many everyday situations, two or more people navigate collaboratively but their spatial knowledge does not necessarily overlap. However, most research to date, has investigated social wayfinding under either 1-sided or fully shared spatial information. [...]

Allergy and autoimmune diseases generate from the dysfunction of the immune system. According to the conventional dogma, both these immunological disorders generate from diverse pathways. [...]