Ph.D. Theses

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2021-10-11
10:13
[DZNE-2021-01292] Dissertation / PhD Thesis

Hippocampal network and inhibitory neuron dysfunction in age and disease
158 pages, 21 figures () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
Aging and Alzheimer' s disease (AD) are two highly intertwined pathological processes. Indeed, one of the highest risk factors for developing AD is age. [...]

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2021-07-21
10:57
[DZNE-2021-00619] Dissertation / PhD Thesis

Propagation of Tau pathology in Alzheimer disease
167 pages, 74 figures () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
Clinical and experimental evidences suggest that the spreading of tau protein throughout the brain may underlie the stereotypical progression of pathology in the brains of Alzheimer disease (AD) patients and concomitant cognitive decline. Although previous studies showed that tau protein can be released, and taken up by cells, several open questions regarding the spreading of tau pathology still exist. [...]

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2021-07-20
13:49
[DZNE-2021-00617] Dissertation / PhD Thesis

Neuroinvasion and cerebral ischemia as possible sources for alpha-synuclein prions in Parkinson's disease
88 pages, 24 figures, 7 tables () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
In synucleinopathies such as Parkinson's disease misfolding of a-synuclein, normally a cellular and soluble protein, leads to the accumulation of insoluble protein aggregates and to central nervous system disease (CNS). Misfolded a-synuclein acts as a seed, by recruiting native a-synuclein and inducing its misfolding into insoluble a-synuclein aggregates. [...]

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2021-07-20
13:48
[DZNE-2021-00616] Dissertation / PhD Thesis

The chromatin organizer Satb1 regulates the differentiation into CD4+Th subsets and is essential for the development of Th17 cells
186 pages, 66 figures, 25 tables () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
CD4+ T cells play a critical role in host defense and tissue homeostasis. Upon encountering their specific antigen, naive CD4+ T cells can differentiate into the effector T helper (TH) subsets THl, TH2, TH9, THl 7 and regulatory T cells (Treg), which fulfill various functions. [...]
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2021-07-20
13:46
OpenAccess [DZNE-2021-00615] Dissertation / PhD Thesis

Locus coeruleus modulates locomotor activity via the medial septum and the diagonal band of Broca
123 pages, 51 figures, 14 tables () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
The locus coeruleus (LC) is positioned in the brainstem and one of the main sources of norepinephrine in the brain. With its projections throughout the whole brain, the LC plays an important role in regulating the general level of arousal and in motivation. [...]
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2021-07-20
13:41
[DZNE-2021-00614] Dissertation / PhD Thesis

Translatome analysis and in vivo Ca2+ imaging of astrocytes in an Alzheimer's disease mouse model
113 pages, 28 figures, 22 tables () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
One of the most prominent hallmarks of Alzheimer's Disease (AD) is the accumulation of amyloid-beta (Aß) species, which have the Lendency to form extracellular insoluble Aß plaques and induce reactive astrogliosis in surrounding astrocytes. We have previously shown that periplaque reactive astrocytes become hyperactive in mouse models of AD (APP /PSl and APPPSl-21), and that one key signalling pathway for this hyperactivity is mediated by purinergic signalling. [...]
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2021-07-20
13:38
OpenAccess [DZNE-2021-00613] Dissertation / PhD Thesis

Odor-evoked Modulation of the Olfactory Bulb by Projections from the Horizontal Limb of the Diagonal Band of Broca
91 pages, 14 figures () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
Olfactory input encodes essential information about the environment and shapes adapted behavioral reactions. Hence, the olfactory system is complex with diverse brain areas processing the sensory input on different levels. [...]
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2021-07-20
13:26
[DZNE-2021-00612] Dissertation / PhD Thesis

Systemic Administration of Epothilones and Pregabalin induces Axon Sprouting and Promotes Functional Recovery in a model of Cortical Stroke
67 pages, 23 figures, 3 tables () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
Strake is a debilitating disease resulting in neuronal lass, axonal degeneration, and sensorimotor deficits. The brain has a limited intrinsic capacity for axonal regeneration after strake, however, thispost-injury compensatory regeneration cannot compensate for the lesion-induced lass of established connections, especially since the growth-inhibitory environment of the peri-stroke region poses afurther hindrance towards regeneration. [...]
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2021-07-20
13:24
[DZNE-2021-00611] Dissertation / PhD Thesis

Investigating the neural circuitry of the Mushroom body calyx in Drosophila melanogaster
92 pages, 18 figures, 12 tables () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
In Drosophila melanogaster, the mushroom body (MB) is essential for the formation and retrieval of olfactory associative memories. Within its input region, the MB calyx, olfactory information is delivered from second order projection neurons (PN) to MB intrinsic neurons. [...]

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2021-07-20
13:23
[DZNE-2021-00610] Dissertation / PhD Thesis

Characterization of cellular functions of the deubiquitinating enzyme OTUD4
128 pages, 28 figures, 13 tables () = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2019
Post-translational modification of proteins with ubiquitin influences myriad of cellular processes by affecting protein stability, degradation, localization and protein-protein interactions. Ubiquitin gets transferred to target proteins via an E1-E2-E3 enzymatic cascade. [...]

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