2021-10-11 10:13 |
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2021-07-21 10:57 |
[DZNE-2021-00619]
Dissertation / PhD Thesis
Ferreira Rodrigues, S.
Propagation of Tau pathology in Alzheimer disease
167 pages, 74 figures (2020)2020 = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
Clinical and experimental evidences suggest that the spreading of tau protein throughout the brain may underlie the stereotypical progression of pathology in the brains of Alzheimer disease (AD) patients and concomitant cognitive decline. Although previous studies showed that tau protein can be released, and taken up by cells, several open questions regarding the spreading of tau pathology still exist. [...]
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2021-07-20 13:49 |
[DZNE-2021-00617]
Dissertation / PhD Thesis
Lohmann, S.
Neuroinvasion and cerebral ischemia as possible sources for alpha-synuclein prions in Parkinson's disease
88 pages, 24 figures, 7 tables (2021)2021 = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
In synucleinopathies such as Parkinson's disease misfolding of a-synuclein, normally a cellular and soluble protein, leads to the accumulation of insoluble protein aggregates and to central nervous system disease (CNS). Misfolded a-synuclein acts as a seed, by recruiting native a-synuclein and inducing its misfolding into insoluble a-synuclein aggregates. [...]
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2021-07-20 13:48 |
[DZNE-2021-00616]
Dissertation / PhD Thesis
Köhne, M. C.
The chromatin organizer Satb1 regulates the differentiation into CD4+Th subsets and is essential for the development of Th17 cells
186 pages, 66 figures, 25 tables (2021)2021 = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
CD4+ T cells play a critical role in host defense and tissue homeostasis. Upon encountering their specific antigen, naive CD4+ T cells can differentiate into the effector T helper (TH) subsets THl, TH2, TH9, THl 7 and regulatory T cells (Treg), which fulfill various functions. [...]
External link: Fulltext
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2021-07-20 13:46 |
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2021-07-20 13:41 |
[DZNE-2021-00614]
Dissertation / PhD Thesis
Blank, N.
Translatome analysis and in vivo Ca2+ imaging of astrocytes in an Alzheimer's disease mouse model
113 pages, 28 figures, 22 tables (2020)2020 = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
One of the most prominent hallmarks of Alzheimer's Disease (AD) is the accumulation of amyloid-beta (Aß) species, which have the Lendency to form extracellular insoluble Aß plaques and induce reactive astrogliosis in surrounding astrocytes. We have previously shown that periplaque reactive astrocytes become hyperactive in mouse models of AD (APP /PSl and APPPSl-21), and that one key signalling pathway for this hyperactivity is mediated by purinergic signalling. [...]
External link: Fulltext
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2021-07-20 13:38 |
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2021-07-20 13:26 |
[DZNE-2021-00612]
Dissertation / PhD Thesis
Kugler, C.
Systemic Administration of Epothilones and Pregabalin induces Axon Sprouting and Promotes Functional Recovery in a model of Cortical Stroke
67 pages, 23 figures, 3 tables (2020)2020 = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
Strake is a debilitating disease resulting in neuronal lass, axonal degeneration, and sensorimotor deficits. The brain has a limited intrinsic capacity for axonal regeneration after strake, however, thispost-injury compensatory regeneration cannot compensate for the lesion-induced lass of established connections, especially since the growth-inhibitory environment of the peri-stroke region poses afurther hindrance towards regeneration. [...]
External link: Fulltext
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2021-07-20 13:24 |
[DZNE-2021-00611]
Dissertation / PhD Thesis
Ranft, P. M.
Investigating the neural circuitry of the Mushroom body calyx in Drosophila melanogaster
92 pages, 18 figures, 12 tables (2020)2020 = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
In Drosophila melanogaster, the mushroom body (MB) is essential for the formation and retrieval of olfactory associative memories. Within its input region, the MB calyx, olfactory information is delivered from second order projection neurons (PN) to MB intrinsic neurons. [...]
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2021-07-20 13:23 |
[DZNE-2021-00610]
Dissertation / PhD Thesis
Das, R.
Characterization of cellular functions of the deubiquitinating enzyme OTUD4
128 pages, 28 figures, 13 tables (2019)2019 = Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2019
Post-translational modification of proteins with ubiquitin influences myriad of cellular processes by affecting protein stability, degradation, localization and protein-protein interactions. Ubiquitin gets transferred to target proteins via an E1-E2-E3 enzymatic cascade. [...]
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