Postdoctoral Theses

Magnetic Resonance Imaging (MRI) is an essential tool in both clinical diagnostics and research, offering a wide range of contrast mechanisms for imaging anatomical structures and assessing tissue properties. One key MRI application is diffusion-weighted imaging (DWI), which sensitizes the MRI signal to the diffusive motion of water molecules, enabling the investigation of tissue microstructure. [...]

Magnetic resonance imaging (MRI) has emerged as a leading, non-ionizing diagnostic tool in medical practice over the last decades. Beyond, MRI has evolved into an expansive field of research, yielding a multitude of novel advancements in technical innovations and a variety of new contrasts. [...]

Magnetic resonance imaging (MRI) is a non-invasive and radiation-free imaging method that has been utilized in medicine for decades. Using magnetic fields, the nuclear spins within the tissue are perturbed, and the resulting magnetization is measured. [...]

Magnetic resonance imaging (MRI) is a versatile imaging modality that has substantially advanced clinical diagnostics by enabling early and accurate detection of disease. However, the inherently low signal-to-noise ratio (SNR) of MRI remains a fundamental limitation and continues to motivate methodological developments. [...]

Pseudo-continuous arterial spin labeling (pCASL) is a magnetic resonance technique for imaging and quantifying cerebral blood flow. Magnetically labeled arterial blood serves as an endogenous tracer. [...]

This study was aimed at evaluating different modulators of amyloid-beta aggregation in Drosophila melanogaster models of Alzheimer’s disease. Fly model studies are cost-effective and fast in vivo systems to screen therapeutic compounds for further testing in mouse models. [...]

Tauopathien sind eine Gruppe von neurodegenerativen Erkrankungen, die durch die Akkumulation von hyperphosphoryliertem Tau, einem Mikrotubuli-assoziierten Protein, gekennzeichnet sind. Sie stellen in Hinblick auf ihre Klinik und Ätiologie ein heterogenes Krankheitsbild dar. [...]

Discovered in 2007, anti-N-Methyl-D-Aspartat receptor (NMDAR) encephalitis is one of the most commonly identified causes for encephalitis. The disease often runs a severe and rapid course showing reduced state of consciousness, epileptic seizures, autonomic dysregulation and hypopnea leading to intensive care unit treatment and even death. [...]

Ektodomänenspaltung und Intramembranproteolyse des Amyloiden Vorläufer Proteins (APP) durch Alpha-, Beta- und gamma-Sekretase sind in die Pathogenese der Alzheimer Erkrankung (AD) involviert. Eine vermehrte proteolytische Prozessierung und Sekretion eines anderen Membranproteins, des Typ II Interleukin-1 Rezeptors (IL-1R2) wurde mit der Pathogenese der Alzheimer Erkrankung in Verbindung gebracht. [...]

The anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common form of autoimmune mediated brain inflammation. Typically patients initially develop psychotic changes such as substantive thought disorders and hallucinations, followed by neurological symptoms like impaired consciousness, dyskinesia, seizures, autonomic dysregulations and central hypoventilation. [...]