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Translocator protein (TSPO)-PET imaging facilitates monitoring of glioblastoma in preclinical models and patients. However, specificity of TSPO-PET signals remains to be investigated. [...]

Early progression after PRRT occurs in a subset of patients with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Associations between body composition and early PET-based progression after PRRT were assessed.In this retrospective analysis, 321 patients undergoing PRRT were screened. [...]

Parkinson's disease (PD) is a complex heterogeneous neurodegenerative syndrome that is clinically defined. However, how it begins at the molecular and systems level remains unresolved. [...]

Renal toxicity after peptide receptor radionuclide therapy (PRRT) is commonly assessed using Common Terminology Criteria for Adverse Events (CTCAE), whereas nephrological classification relies on Kidney Disease: Improving Global Outcomes (KDIGO)-based renal function categories. We compared CTCAE- and KDIGO-derived eGFRcr-based definitions of renal function deterioration after PRRT and evaluated their predictive value for subsequent long-term renal outcome.149 gastroenteropancreatic neuroendocrine tumor patients scheduled for PRRT with renal follow-up for at least 12 months after treatment were included. [...]

Endovascular thrombectomy (EVT) is established for large infarcts, but remains cautiously applied in extensive infarcts with an Alberta Stroke Program Early CT Score (ASPECTS) of 0-2. Real-life outcome data remain limited.Retrospective analysis of the German Stroke Registry-Endovascular Treatment comparing extensive (ASPECTS 0-2) and large infarcts (ASPECTS 3-5) in patients with anterior-circulation occlusion and EVT. [...]

Neuroinfectious diseases (NDs) are potentially treatable conditions associated with substantial morbidity, but their clinical course remains difficult to predict. While specific MRI patterns are characteristic of distinct aetiologies, their prognostic value remains poorly investigated. [...]

Real-time quaking-induced conversion (RT-QuIC) of recombinant prion protein is a biomarker for Creutzfeldt-Jakob disease (CJD). RT-QuIC assesses a sample's seeding activity across multiple wells. [...]

Liver MRI plays a critical role in the diagnosis and monitoring of liver disease; however, image quality is often degraded by respiratory motion and noise, particularly in high-resolution and diffusion-weighted imaging. Propeller-based sequences such as BLADE improve motion robustness, but advanced reconstruction strategies are required to fully exploit their potential under accelerated conditions.We propose a phase-constrained zero-shot self-supervised learning (PC ZS-SSL) framework for BLADE liver MRI reconstruction. [...]

With aging societies, the incidence and prevalence of dementia are increasing rapidly and will continue to do so worldwide in the next years and decades. It is now possible to diagnose dementia at an early stage using neuropsychological tests and biomarker studies, including imaging (MRI, PET), cerebrospinal fluid analysis, and genetic testing. [...]

Focal Cortical Dysplasia (FCD) is a leading cause of drug-resistant focal epilepsy, and its identification on Magnetic Resonance Imaging (MRI) can enable potentially curative surgical treatment. FCD features are often subtle and heterogeneous and current deep learning models for automated detection exhibit limited sensitivity. [...]