Documents in Process

[18F]fluorodeprenyl-D2 ([18F]F-DED) positron emission tomography (PET) imaging detects reactive astrogliosis in patients with autoimmune encephalitis (AIE) and multiple system atrophy (MSA). Although dynamic 60-min acquisitions are established, shorter static imaging protocols are desirable for severely impaired patients. [...]

Sleep is multidimensional, and it remains unclear which aspects are most relevant to cognition and dementia risk. We aimed to apply a data-driven approach to identify clusters of sleep variables that reflect meaningful sleep composites and examined their association with cognition and dementia risk.This was a prospective observational cohort study that used data from the Sleep and Dementia Consortium, comprising 5 US population-based cohorts. [...]

To design and develop an 8-channel transmit 32-channel receive 11.7T head coil for the strongest human MRI scanner to date, demonstrate safety, and evaluate signal-to-noise ratio (SNR) gains compared to 7T, the most used ultra-high-field (UHF) platform.The transmit array design incorporated a folded-end radiofrequency (RF) shield to mitigate wave propagation in the scanner bore. The receive array consisted of 32-overlapped loops constructed on a helmet size-matched with the industry standard 7T head coil. [...]

To integrate MR-based servo navigation in MPRAGE and 3D-TSE sequences and demonstrate its potential for prospective head motion correction in structural imaging.Repeated modules of servo navigators were inserted before each preparation pulse of MPRAGE and 3D-TSE sequences (before-prep) for rapid convergence of motion parameter estimation. Additionally, reference navigators were distributed along the imaging echo train to test a within-echo train correction (within-ET) with contrast-matched models, enabling more frequent geometry updates. [...]

To demonstrate the synergy of undersampled radial 2in1-RARE-EPI acquisition and nonlinear model-based reconstruction for accelerated and simultaneous T2, T2*, and R2' mapping in brains of patients with multiple sclerosis (MS).2in1-RARE-EPI combines a RARE module with an EPI module to capture T2 and T2* information. Nonlinear model-based reconstruction was applied to estimate T2, T2* maps directly from undersampled k-space data. [...]

Clinical prognostication and decision-making in IDH-mutant glioma is increasingly complex, especially with new targeted treatment options like IDH-inhibitors. Individual patient risk stratification for better treatment planning is needed; however, standard prognostic models rely on clinical and histologic parameters as well as MRI, which may not fully reflect the tumor's biological behavior. [...]

Postoperative delirium (POD) is a frequent and severe complication after cardiac surgery that is associated with increased risk of dementia and adverse outcomes. Early identification of high-risk patients remains challenging.To examine whether preoperative plasma Alzheimer disease biomarkers are associated with baseline cognition and can independently estimate POD in patients undergoing elective cardiac surgery.This prospective, observational cohort study (FIND Delirium Risk Factors [FINDERI]) included patients 50 years or older undergoing elective cardiac surgery at a comprehensive cardiac surgery center in Germany between February 1, 2021, and October 31, 2022. [...]

What makes some people willing to help strangers at a personal cost, while others are more hesitant or selective? Early life adversity - such as neglect or abuse - may shape how we respond to strangers in need later in life, yet the underlying neural mechanisms remain unclear. In this study we tested whether the neuropeptide oxytocin, a key modulator for a rich repertoire of social behaviours, influences altruistic decisions in adults with different childhood experiences. [...]

Protecting hippocampal structures, such as the cornu ammonis 3 and dentate gyrus (CA3/DG), that are tied to mnemonic discrimination could be a promising approach to mitigate the age-related decline in episodic memory. This study examines the potential benefits of cognitive and physical engagement, specifically language learning and moderate aerobic exercise, for maintaining hippocampal subfield integrity and memory performance. [...]

Auger-electron-emitting radionuclides offer a distinctive route toward molecular-scale radiotherapy because their biological effects depend primarily on the nanoscale location of the decay event rather than on long-range tissue penetration. This review examines Auger-emitting radionuclides from a radiopharmaceutical perspective, integrating decay-associated physicochemical processes, cellular dosimetry, subcellular targeting, and translational relevance. [...]