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2025-07-01
16:30
DBCoverage [DZNE-2025-00757] Journal Article
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Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.
Serum lipid levels, which are influenced by both genetic and environmental factors, are key determinants of cardiometabolic health and are influenced by both genetic and environmental factors. Improving our understanding of their underlying biological mechanisms can have important public health and therapeutic implications. [...]

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2025-07-01
16:29
pmc [DZNE-2025-00756] Journal Article
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Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease.
Molecular psychiatry 30(7), 3150 - 3159 () [10.1038/s41380-025-03021-0]
Subjective cognitive decline (SCD) is proposed as an indicator of transitional disease stage 2 in the Alzheimer's disease (AD) continuum. However, molecular and particularly longitudinal fluid biomarker data for this stage are still limited. [...]

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2025-07-01
16:21
pmc [DZNE-2025-00755] Journal Article
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A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy.
Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. [...]

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2025-07-01
16:16
[DZNE-2025-00754] Journal Article
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Low income, being without employment, and living alone: how they are associated with cognitive functioning-Results from the German national cohort (NAKO).
Aim was to investigate to what extent cognitive functioning differs by three socioeconomic conditions: low income, being without employment, and living alone. A total of N = 158,144 participants of the population-based German National Cohort (NAKO) provided data on socioeconomic conditions and completed cognitive tests. [...]

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2025-07-01
16:11
[DZNE-2025-00753] Journal Article
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Constitutive HIF-1α Expression in the Epidermis Fuels Proliferation and Is Essential for Effective Barrier Formation.
Epidermis is one of the most rapidly proliferating tissues in the body with high demands for adenosine triphosphate and cellular building blocks. In this study, we show that to meet these requirements, keratinocytes constitutively express HIF-1α, even in the presence of oxygen levels sufficient for HIF-1α hydroxylation. [...]

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2025-07-01
16:10
DBCoverage [DZNE-2025-00752] Journal Article
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Role of Compensatory miRNA Networks in Cognitive Recovery from Heart Failure.
Background: Heart failure (HF) is associated with an increased risk of cognitive impairment and hippocampal dysfunction, yet the underlying molecular mechanisms remain poorly understood. This study aims to investigate the role of microRNA (miRNA) networks in hippocampus-dependent memory recovery in a mouse model of HF. [...]

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2025-07-01
15:57
[DZNE-2025-00751] Journal Article
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Serum neurofilament light chain and multimodal neuroprognostication after cardiac arrest - A retrospective cohort study.
Most patients remain comatose within the first days after cardiac arrest (CA) and resuscitation. Guidelines recommend multimodal neuroprognostication including neuron specific enolase (NSE) as serum biomarker. [...]

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2025-07-01
15:56
DBCoverage [DZNE-2025-00750] Journal Article
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Neural dynamics of visual working memory representation during sensory distraction.
eLife 13, RP99290 () [10.7554/eLife.99290]
Recent studies have provided evidence for the concurrent encoding of sensory percepts and visual working memory (VWM) contents across visual areas; however, it has remained unclear how these two types of representations are concurrently present. Here, we reanalyzed an open-access fMRI dataset where participants memorized a sensory stimulus while simultaneously being presented with sensory distractors. [...]

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2025-07-01
15:55
pmc [DZNE-2025-00749] Journal Article
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Utility, Costs and Cost-Utility of Amyloid-PET in the Diagnostic Process of Memory Clinic Patients: A Trial-Based Economic Evaluation From AMYPAD-DPMS.
Amyloid positron emission tomography (PET) is instrumental in achieving an accurate diagnosis and may help to limit health-seeking behavior. Currently, amyloid-PET is not routinely used in clinical practice due to lack of evidence on cost-utility. [...]

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2025-07-01
15:53
pmc [DZNE-2025-00748] Journal Article (Review Article)
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Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview.
Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. [...]

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