Documents in Process

The optimal monitoring strategy for atrial fibrillation (AF) detection after transient ischemic attacks (TIAs) is uncertain, as existing evidence is largely derived from ischemic stroke or mixed stroke-TIA populations. This systematic review and meta-analysis aimed to determine the rate of newly diagnosed AF in TIA patients using different electrocardiographic monitoring modalities and durations.A literature search from 1966 through 31 May 2025 was conducted according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines using a protocol registered on PROSPERO (CRD420251075716). [...]

Aging is frequently assessed through lifespan extension and proxy biomarkers, yet these approaches may not fully capture the complexity of biological aging. Here, we propose refinements to discovery and evaluation strategies in aging research. [...]

Intermittent theta burst stimulation (iTBS) is a promising noninvasive treatment for major depressive disorder (MDD), though significant variability exists in patient responses. This quadruple-blind, sham-controlled crossover randomized clinical trial investigated whether clinical improvement was influenced by the spatial selection of stimulation sites or early cardiac rhythm modulations. [...]

Background: There are currently no sex-specific recommendations for antipsychotic prescribing in schizophrenia, although women may be more susceptible to certain side-effects and may require lower doses to achieve comparable efficacy to men. However, sex differences remain insufficiently studied to inform treatment decisions.Methods: We plan a systematic review and individual-participant-data meta-analysis of randomized trials comparing different antipsychotic drugs, doses, formulations with each other or with placebo in adults with acute schizophrenia. [...]

The relationship between sleep disorders and neurodegeneration is complex. Using >1 million electronic health records from Wales, UK, and Finland, we mined biobank data to identify relationships between sleep disorders and neurodegenerative diseases (NDDs). [...]

Early perfusion amyloid-PET imaging is emerging as a valuable tool to potentially capture patients’ neurodegeneration patterns, allowing same-day, same-tracer categorization of both amyloidosis (A) and neurodegeneration (N) biomarkers. Early perfusion amyloid-PET might provide an added value for differential diagnosis and, in keeping with the capability of FDG-PET to indirectly track co-pathology in AD patients, it may complement the information provided by amyloid PET thus supporting a more accurate weighting of the different underlying pathological processes. [...]

Die Deutsche Gesellschaft für Neurologie (DGN) möchte die strukturierte Weiterbildung im gesamten Bereich neuroimmunologischer Erkrankungen und damit die Sicherung der Qualität ärztlicher Berufsausübung in diesem wachsenden Feld sicherstellen. Daher hat sie ihre Klinische Kommission „Neuroimmunologie“ damit beauftragt, entsprechend der Musterweiterbildungsordnung (MWBO) der Bundesärztekammer (BÄK) einen Entwurf für einen „Schwerpunkt Neuroimmunologie“ zu erarbeiten. [...]

While inhibition of terminal complement activation is an effective therapeutic strategy in acetylcholine receptor antibody-positive generalized myasthenia gravis (AChR-Ab+ gMG) and aquaporin‑4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-Ab+ NMOSD), it is associated with an increased risk for invasive meningococcal infection. As such, all patients receiving complement inhibitors—including eculizumab, ravulizumab, and zilucoplan—require vaccination against meningococcal serogroups A, C, W, Y (MenACWY) and B (MenB). [...]