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Death domain-associated protein (Daxx) is one of the two main H3.3 chaperones in mammalian cells and acts as key repressor of RTEs of viral origin. In present study, we found that Daxx is an IFN-stimulated gene mediating repression of RTEs and IFN-stimulated genes (ISGs) upon inflammatory stimuli in microglia. [...]

Death domain-associated protein (Daxx) is one of the two main H3.3 chaperones in mammalian cells and acts as key repressor of RTEs of viral origin. In the present study, we found that Daxx is an IFN-stimulated gene mediating repression of RTEs and IFN-stimulated genes (ISGs) upon inflammatory stimuli in microglia. [...]

Death domain-associated protein (Daxx) is one of the two main H3.3 chaperones in mammalian cells and acts as key repressor of RTEs of viral origin. In present study, we found that Daxx is an IFN-stimulated gene mediating repression of RTEs and IFN-stimulated genes (ISGs) upon inflammatory stimuli in microglia. [...]

Death domain-associated protein (Daxx) is one of the two main H3.3 chaperones in mammalian cells and acts as key repressor of RTEs of viral origin. In present study, we found that Daxx is an IFN-stimulated gene mediating repression of RTEs and IFN-stimulated genes (ISGs) upon inflammatory stimuli in microglia. [...]

Hemispherotomy is a surgical intervention for severe drug-resistant epilepsy that fully disconnects the lesional brain hemisphere from the rest of the nervous system. This creates a rare opportunity to explore whether consciousness can be sustained without external input. [...]

This study investigates how to improve the reliability of probability estimates produced by deep learning models for the detection of Alzheimer’s disease using MRI data. Although convolutional neural networks (CNNs) can accurately classify neurodegenerative diseases, their softmax outputs often misrepresent true classification probabilities. [...]

The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of tau regulation, degradation, and propagation; advances in biomarker development for the diagnosis and staging of tauopathies; and evolving therapeutic strategies targeting diverse aspects of tau pathophysiology. [...]

Ictal single-photon emission computed tomography (SPECT) is an imaging technique used to identify the seizure-onset zone (SOZ) in epilepsy patients. It visualizes increased cerebral blood flow near the SOZ through radiopharmaceuticals injected shortly after seizure onset. [...]

Accurately predicting age at symptom onset in genetic frontotemporal dementia (FTD) remains challenging due to substantial inter-individual variability, even among carriers of distinct pathogenic variants within the same gene. Time-to-event models provide a natural framework to address this problem while accounting for right censoring in presymptomatic individuals. [...]

Disruption of circadian rhythms is a key feature of neurodegenerative diseases and a non-motor feature of Parkinson's disease, which significantly impairs health-related quality of life; yet, the underlying mechanisms are only partially understood. Preclinical animal models with neuropathological and symptomatic significance might contribute to a better understanding of circadian dysfunction. [...]