Documents in Process

We investigated the diagnostic utility of the plasma glial fibrillary acidic protein (GFAP)/neurofilament light chain (NfL) ratio in genetic frontotemporal dementia (FTD) and compared its performance with GFAP and NfL alone.Baseline plasma samples were available from 391 pathogenic variant carriers and non-carriers, with longitudinal samples (≥2) from 259 participants. Linear mixed-effects models were used to assess baseline differences between clinical groups, longitudinal trajectories, and the ability of the GFAP/NfL ratio to discriminate underlying TAR DNA-binding protein (TDP) versus tau pathology.Baseline GFAP/NfL ratios differed across clinical groups; however, the ratio did not outperform GFAP or NfL alone in any clinically relevant comparison. [...]

Alterations in electromechanical coupling have been described in patients with amyotrophic lateral sclerosis (ALS) and may contribute to the pathophysiology of the disease. Regardless of this, few measurements of electromechanical delay (EMD) in ALS patients have been published. [...]

Alzheimer's disease (AD) is commonly diagnosed when neuronal damage is already established and irreversible. Achieving an accurate differential diagnosis in the preclinical and mild cognitive impairment (MCI) stage is one of the greatest challenges nowadays. [...]

To evaluate associations between respiratory support strategies, partial pressure of carbon dioxide (pCO2) variability and oxygen exposure in neonates with hypoxic-ischaemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH).This retrospective multicentre study used data from the German Hypothermia Registry, including neonates ≥ 36 weeks with moderate-to-severe HIE treated with TH between 2022 and 2025. Respiratory support was categorized as continuous positive airway pressure (CPAP) or invasive ventilation. [...]

To improve signal strength and homogeneity of whole-brain diffusion-weighted imaging (DWI) at 7T.Universal multiband excitation and refocusing pulses were optimized with the gradient ascent pulse engineering (GRAPE) algorithm across a database of B 1 + and B 0 maps obtained from 20 subjects. Slice-selective multiband pulses were optimized in a two-step optimization for transverse and sagittal slice orientations. [...]

Prion diseases are inevitably fatal, rare, and infectious neurodegenerative diseases of humans and animals. Initially, they were thought to be caused by unconventional slow viruses, and early research therefore relied heavily on experimental approaches used in virology. [...]

Artificial intelligence (AI) is expected to become increasingly important in hospitals and clinical care. However, successful implementation depends on technical, organizational, and user-related factors. [...]

The ability to remember where objects are located is a fundamental cognitive function particularly vulnerable to aging and neurodegenerative disease. Previous functional magnetic resonance imaging (fMRI) research has combined object-location memory (OLM) with broader spatial memory and navigation tasks, resulting in inconsistent findings. [...]

BackgroundSubjective cognitive decline (SCD) is recognized as an early indicator of preclinical Alzheimer's disease (AD). However, individuals with SCD do not exhibit cognitive impairment on standard neuropsychological tests. [...]

The transcription factor TATA-box-binding protein (TBP) plays a crucial role in neurons, as highlighted by its involvement in spinocerebellar ataxia type 17 (SCA17), where pathological polyglutamine expansions disrupt its function. While the molecular pathomechanisms remain unclear, our previous study showed that calcium-activated calpains cleave TBP in SCA17 cell and animal models. [...]