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Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and expert opinion suggest PKAN, BPAN, PLAN, and MPAN are the most common subtypes. [...]

Background: Scalable, process-sensitive tools are needed to address the gap between neuropathological onset and clinical recognition of cognitive decline. Tablet-based assessments can capture behavioral and temporal data beyond conventional test metrics, but require validation in target populations. [...]

This dataset contains epigenome-wide association study (EWAS) summary statistics for ten diet quality scores from the Rhineland Study, a population-based cohort (n = 5,768 participants).Traits included (diet quality scores): Mediterranean Diet Score (MDS), Dietary Approaches to Stop Hypertension (DASH), Mediterranean–DASH Intervention for Neurodegenerative Delay (MIND), Alternate Healthy Eating Index (AHEI), Nordic diet score, Plant-based Diet Index (PDI), Healthful Plant-based Diet Index (hPDI), Unhealthful Plant-based Diet Index (uPDI), Dietary Inflammatory Index (DII), and EAT-Lancet diet score.The repository also includes generic scripts, adapted for general use, for calculating adherence to the diet quality scores, performing the EWAS analyses, generating the descriptive tables, and fitting the linear regression models for the associations between the diet quality scores and epigenetic aging outcomes.This work accompanies the manuscript "Associations between diet quality, epigenetic aging, and the epigenome: Findings from two population-based studies."

Bulk RNA-seq dataset of microglia isolated from a transgenic Parkinson's disease mouse model (Camk2a-tTA; V1S/SV2 α-synuclein). Microglia were enriched from adult brain by enzymatic dissociation (Miltenyi Adult Brain Dissociation Kit), Anti-O4 oligodendrocyte depletion, and CD11b positive selection (~2 M cells per pooled sample). [...]

Data and analysis code accompanying the manuscript "An intrinsic cytoskeletal oscillator establishes neuronal polarity". The study shows that the neuronal soma acts as a central organiser of axon–dendrite polarity through a soma-initiated, Arp2/3-driven actin oscillator: periodic somatic actin waves remodel a global actomyosin network, transiently relax myosin-II contractility at a single neurite tip, and bias that neurite toward axon fate. [...]

This dataset contains epigenome-wide association study (EWAS) meta-analysis summary statistics for hippocampal imaging traits from six population-based cohorts (n = 8,156 participants). Traits included:- left hippocampal volume (LHCV)- right hippocampal volume (RHCV)- hippocampal asymmetry (HCasy)- sex-stratified HCasy analysesThe repository also includes generic scripts used to perform cohort-level EWAS analyses..

This repository provides a compact MATLAB/SPM12 implementation of representational-similarity analyses for navigation fMRI data. It includes a fully reproducible mock-data workflow that generates synthetic two-run BOLD data, event files, motion regressors, and example pmEC, retrosplenial cortex, and presubiculum ROIs. [...]

The variant annotations used in the manuscript "Genomic foundation models do not yet boost common variant discovery", on ~7M 1000 Genomes EUR SNPs (MAF > 0.01). The models included are AlphaGenome (eight output types), the 102 principal components of Borzoi variant effect scores (Sniff), GPN-Star constraint scores (three, with their top-0.1% indicators), Zoonomia constraint (two), the AlphaGenome variant impact score (AVI), and the 96 baselineLD (v2.2) annotations..

QCima Studio is a standalone software application for quality control of MACSima spatial proteomics datasets. It provides convenient access to review individual antibody signals alongside their corresponding background and autofluorescence reference images.Users can adjust visualization settings, classify signals as accepted or discarded, and automatically organize imaging data by scene (Rack–Well–ROI), antibody, and autofluorescence reference.The software is designed for fast, script-free QC workflows and supports session saving, analysis resumption, structured metadata review, and seamless transfer of QC decisions back to MACS iQ View..

This repository contains the MATLAB/SPM12 analysis scripts that implement the first-level fMRI model and region-of-interest representational similarity analyses used to quantify six-fold grid-cell-like representations and their temporal stability across runs.The repository includes:A first-level GLM in which translation events are grouped into six directional phase regressors. Each regressor combines movement directions separated by 60°, producing phase offsets of 0°, 10°, 20°, 30°, 40°, and 50°.An ROI-based representational similarity analysis that extracts voxelwise beta patterns for the six phase conditions from each run.Calculation of run-specific neural representational dissimilarity matrices (RDMs) using correlation distance Calculation of a cross-run neural RDM and its Spearman correlation with a theoretical six-fold model RDM (grid-cell-like signal magnitude)Assessment of temporal stability as the Spearman correlation between the unique off-diagonal elements of the run-1 and run-2 neural RDMs (temporal stability metric)A fully synthetic mock dataset generator for testing the complete analysis pipeline.The mock dataset follows the main acquisition and task structure, with a repetition time of 2.2 seconds, two runs of 246 volumes, six motion regressors per run, semicolon-delimited event files, and a synthetic ROI mask. [...]