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Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically heterogenous. The application of omics technologies-mainly studying nucleic acids-has significantly improved MB classification and stratification, but treatment options are still unsatisfactory. [...]

Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using optical imaging. The viral transduction of GECIs is commonly used to target expression to specific brain regions, can be conveniently used with any mouse strain of interest without the need for prior crossing with a GECI mouse line, and avoids potential hazards due to the chronic expression of GECIs during development. [...]

Our proposed EPVS segmentation challenge focuses on detection of Enlarged Perivascular Spaces (EPVS) in brain MRIs. EPVS is a crucial neuroimage indicator of cerebral vascular disease, linked to conditions like small vessel disease and cognitive impairment risks. [...]

Training checkpoints for HypVINN (https://github.com/Deep-MI/FastSurfer) - please cite the paper when using this resource (https://doi.org/10.1162/imag_a_00034). Abstract The hypothalamus plays a crucial role in the regulation of a broad range of physiological, behavioral, and cognitive functions. [...]

This data repository contains an example of the acquired MRI sequences and the output of the post-processing pipelines in the Rhineland Study. An overview and information about the MRI sequences and post-processing pipelines can be found in our work 'Versatile MRI Acquisition and Processing Protocol for Population-Based Neuroimaging.' (under-submission)

Dataset used in a paper 'Using temperature coefficients to support resonance assignment of intrinsically disordered proteins' by Paulina Putko, Javier Agustin Romero, Christian F. Pantoja, Markus Zweckstetter, Krzysztof Kazimierczuk, and Anna Zawadzka-Kazimierczuk [...]

To obtain a general TR catalog across the human genome, we identified genomic intervals with a stretch of exact repetitions of a DNA motif ranging from 1-6bp on GRCh38 autosomes and sex chromosomes by using STRfinder (v1.0). To end up, we successfully found 1,233,959 TR intervals, covering 0.783306% (34 Mbp) of GRCh38 (https://console.cloud.google.com/storage/browser/_details/genomics-public-data/resources/broad/hg38/v0/Homo_sapiens_assembly38.fasta)..

To obtain a general TR catalog across the human genome, we identified genomic intervals with a stretch of exact repetitions of a DNA motif ranging from 1-6bp on GRCh38 autosomes and sex chromosomes by using STRfinder (v1.0), and each STR region was annotated based on gencode.V38 (https://www.gencodegenes.org/human/release_38.html). To end up, we successfully found 1,233,959 TR intervals, covering 0.783306% (34 Mbp) of GRCh38 (https://console.cloud.google.com/storage/browser/_details/genomics-public-data/resources/broad/hg38/v0/Homo_sapiens_assembly38.fasta)..

Synaptic dysfunction is a key feature of SHANK-associated disorders such as autism spectrum disorder, schizophrenia, and Phelan-McDermid syndrome. Since detailed knowledge of their effect on synaptic nanostructure remains limited, we aimed to investigate such alterations in ex11|SH3 SHANK3-KO mice combining expansion and STED microscopy. [...]

Repository for the datasets, code, and images underlying figures in the manuscript 'Combined expansion and STED microscopy reveals altered fingerprints of postsynaptic nanostructure across brain regions in ASD-related SHANK3-deficiency'. The folder structure is organized according to associated figures: Figure_NHSE-EF (Figures 1/S1), Figure_SYNLOC (Figure 2/S2-S3), Figure_REGSHAPE-SH3SHAPE (Figure 3/S4-S8), Figure_SH3STED (Figure 4-5/S9-S14), Figure_S15. [...]