Documents in Process

Effective disease-modifying therapies remain unavailable for neurodegenerative diseases (NDDs). Tyrosine kinase inhibitors (TKIs) indicated for chronic myeloid leukemia (CML) have been hypothesized to modulate the pathological mechanisms underlying neurodegeneration. [...]

The increased utility of quantitative metrics in medical imaging has prompted the use of colour representation of the data. Colour schemes for image display can highlight pathology and distinguish normal anatomy, thus potentially aiding image interpretation. [...]

Background: Differentiating Cerebral Amyloid Angiopathy (CAA) from Alzheimer's disease (AD) in vivo is challenging due to overlapping amyloid pathology and limited availability sensitivity of hemorrhagic markers in memory clinic settings. We investigated whether integrating regional cortical atrophy with cerebrospinal fluid (CSF) neurofilament light chain (NfL), a marker of axonal injury, might have a diagnostic value. [...]

Background: Neurodegenerative diseases often feature a prolonged phase of subtle changes preceding diagnosis. In amyotrophic lateral sclerosis (ALS), defining this prodromal period is critical for identifying early disease features and intervention windows. [...]

Introduction: The α-synuclein seed amplification assay (synSAA) is a biomarker test for synucleinopathies. Different synSAA conditions have different properties, and some of these conditions enable differentiation between diseases associated with Lewy bodies versus those associated with glial inclusions. [...]

Loss of retinal pigment epithelium (RPE) in the eye leads to photoreceptor dysfunction, death, and eventually, vision loss. Cell replacement strategies using RPE cells derived in vitro from pluripotent stem cells are currently evaluated as a potential therapeutic strategy. [...]

Postoperatives Delir (POD) ist eine häufige und klinisch hochrelevante Komplikation nach herzchirurgischen Eingriffen, die mit erhöhter Morbidität und Mortalität sowie verlängerten Aufenthalten auf der Intensivstation und im Krankenhaus assoziiert ist. Der Einfluss intra- und früher postoperativer Faktoren auf das Auftreten eines POD bei herzchirurgischen Patienten ist bislang nicht eindeutig geklärt. [...]

Motion artefacts in magnetic resonance brain images can have a strong impact on diagnostic confidence. The assessment of MR image quality is fundamental before proceeding with the clinical diagnosis [...]

Magnetic resonance imaging (MRI) inherently suffers from noise, which limits downstream medical analyses. In MRI, noise-free images are unobtainable; therefore, existing denoising approaches formulate surrogate training objectives, compromising between preserving detail and concealing noise, causing domain shifts or incomplete denoising. [...]