Documents in Process

Introduction: Deep brain stimulation is an effective therapy for patients with isolated dystonia. In pallidal local field potential recordings, theta was identified as a biomarker for symptom severity, and beta as a transdiagnostic biomarker for bradykinesia. [...]

The number of randomized-controlled trials (RCTs) originating from China is considerable. However, linguistic barriers and concerns regarding methodological rigor impede their inclusion in meta-analyses.We searched 5 major Chinese databases for RCTs investigating antipsychotics in schizophrenia and contacted study authors to request information about reliability and methods of randomization and blinding using a semi-structured telephone interview and a specifically-designed online questionnaire in Chinese.Among 11,306 articles, 5117 purported RCTs were eligible. [...]

In human pose estimation, a comprehensive evaluation of state-of-the-art frameworks is necessary to advance both research and practical applications. This paper presents a thorough review of state-of-the-art 2D and 3D human pose estimation frameworks, analyzing 118 papers and four GitHub repositories, with a focus on frameworks made since 2019. [...]

Primary progressive aphasia (PPA) is a neurodegenerative disease that leads to progressive impairment of language and communication, with serious consequences for the daily lives of affected patients.As part of an international research collaboration (https://www.comet-initiative.org/Studies/Details/1871), important endpoints for investigating the success of (speech and language) therapy for people with PPA were developed (Core Outcome Set for PPA, COS-PPA). Here we report the results from Germany, discuss them in the context of the overall project, and compare them with the core outcomes for post-stroke aphasia.Six small group interviews were conducted with n=9 patients with PPA and n=13 caregivers using the nominal group technique to ask about wishes and goals regarding communication and speech-language therapy as well as their importance.PPA patients emphasised linguistic goals, while care partners focused on communication relevant to everyday life and psychological aspects. [...]

Acute myocardial injury occurs in about every fourth patient in the early phase after ischemic stroke. It may be caused by an imbalance between myocardial oxygen supply and demand, potentially leading to type 2 myocardial infarction (MI). [...]

Alzheimer's disease involves trans-synaptic spread of tau pathology from temporal lobe epicenters, driven by amyloid beta (Aβ) deposition. How modular brain network architecture shapes this process and the ensuing cognitive decline remains incompletely understood. [...]

Despite evidence of early neurodegeneration, postural instability is commonly associated with later stages of Parkinson's disease (PD), mainly due to a lack of sensitive measures. Here, we aim to provide a sensitive, easily obtainable objective measure of postural instability for earlier clinical detection. [...]

We investigated the role of copy number variations (CNVs) in Parkinson's disease (PD) using genotyping data from 10,815 patients (2731 early-onset PD, EOPD) and 8901 controls from the COURAGE-PD consortium. CNVs were analyzed using a sliding window genome-wide association and burden approach. [...]