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2021-12-16
16:18

[DZNE-2021-01592] Journal Article

Tin, A. ; Schlosser, P. ; Matias-Garcia, P. R. ; et al
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.

Nature Communications 12(1), 7173 (2021) [10.1038/s41467-021-27198-4]

Elevated serum urate levels, a complex trait and major risk factor for incident gout, are correlated with cardiometabolic traits via incompletely understood mechanisms. DNA methylation in whole blood captures genetic and environmental influences and is assessed in transethnic meta-analysis of epigenome-wide association studies (EWAS) of serum urate (discovery, n = 12,474, replication, n = 5522). [...]

ddc:500

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2021-12-16
16:17

[DZNE-2021-01591] Journal Article

Schlosser, P. ; Tin, A. ; Matias-Garcia, P. R. ; et al
Meta-analyses identify DNA methylation associated with kidney function and damage.

Nature Communications 12(1), 7174 (2021) [10.1038/s41467-021-27234-3]

Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. [...]

ddc:500

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