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Stimulation of the innate immune system has been implicated in ALS and particularly in distinct monogenic forms of ALS. To address whether this is of diagnostic value, we performed a proof-of concept study using qPCR to assess the Interferon score in blood samples of genetic ALS. [...]

Stimulation of G protein-coupled receptors (GPCRs) that couple to Gi/o leads to the activation of G protein-activated inward rectifier K+ (GIRK) channels and membrane hyperpolarization in excitable cells. GIRK channel availability can determine the success of optogenetic silencing strategies based on Gi/o-coupled GPCRs. [...]

The cortico-subthalamic hyperdirect pathway provides a rapid route for cortical influence over basal ganglia processing and is a key target of deep brain stimulation (DBS) in Parkinson's disease (PD). However, to what degree dopamine modulates signal transmission along this pathway in humans remains unclear. [...]

VPS13A belongs to the family of bridge-like lipid transfer proteins, which connect opposing membranes at organelle contact sites in order to facilitate bulk lipid transfer. Loss of function mutations in the VPS13A gene cause VPS13A disease. [...]

Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and expert opinion suggest PKAN, BPAN, PLAN, and MPAN are the most common subtypes. [...]

Background: Scalable, process-sensitive tools are needed to address the gap between neuropathological onset and clinical recognition of cognitive decline. Tablet-based assessments can capture behavioral and temporal data beyond conventional test metrics, but require validation in target populations. [...]

This dataset contains epigenome-wide association study (EWAS) summary statistics for ten diet quality scores from the Rhineland Study, a population-based cohort (n = 5,768 participants).Traits included (diet quality scores): Mediterranean Diet Score (MDS), Dietary Approaches to Stop Hypertension (DASH), Mediterranean–DASH Intervention for Neurodegenerative Delay (MIND), Alternate Healthy Eating Index (AHEI), Nordic diet score, Plant-based Diet Index (PDI), Healthful Plant-based Diet Index (hPDI), Unhealthful Plant-based Diet Index (uPDI), Dietary Inflammatory Index (DII), and EAT-Lancet diet score.The repository also includes generic scripts, adapted for general use, for calculating adherence to the diet quality scores, performing the EWAS analyses, generating the descriptive tables, and fitting the linear regression models for the associations between the diet quality scores and epigenetic aging outcomes.This work accompanies the manuscript "Associations between diet quality, epigenetic aging, and the epigenome: Findings from two population-based studies."

Bulk RNA-seq dataset of microglia isolated from a transgenic Parkinson's disease mouse model (Camk2a-tTA; V1S/SV2 α-synuclein). Microglia were enriched from adult brain by enzymatic dissociation (Miltenyi Adult Brain Dissociation Kit), Anti-O4 oligodendrocyte depletion, and CD11b positive selection (~2 M cells per pooled sample). [...]

Data and analysis code accompanying the manuscript "An intrinsic cytoskeletal oscillator establishes neuronal polarity". The study shows that the neuronal soma acts as a central organiser of axon–dendrite polarity through a soma-initiated, Arp2/3-driven actin oscillator: periodic somatic actin waves remodel a global actomyosin network, transiently relax myosin-II contractility at a single neurite tip, and bias that neurite toward axon fate. [...]

This dataset contains epigenome-wide association study (EWAS) meta-analysis summary statistics for hippocampal imaging traits from six population-based cohorts (n = 8,156 participants). Traits included:- left hippocampal volume (LHCV)- right hippocampal volume (RHCV)- hippocampal asymmetry (HCasy)- sex-stratified HCasy analysesThe repository also includes generic scripts used to perform cohort-level EWAS analyses..