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2021-12-16
16:18
DBCoverage [DZNE-2021-01592] Journal Article
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Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
Elevated serum urate levels, a complex trait and major risk factor for incident gout, areĀ correlated with cardiometabolic traits via incompletely understood mechanisms. DNA methylation in whole blood captures genetic and environmental influences and is assessed in transethnic meta-analysis of epigenome-wide association studies (EWAS) of serum urate (discovery, n = 12,474, replication, n = 5522). [...]

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2021-12-16
16:17
DBCoverage [DZNE-2021-01591] Journal Article
; ; ; et al
Meta-analyses identify DNA methylation associated with kidney function and damage.
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. [...]

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