Documents in Process

Objectives: We aimed to investigate the mediating role of lifestyle activities in the association between social deprivation and cognition. Methods: To investigate, we analysed data of 3867 respondents (Mean Age: 73.37, SD: 5.57) in the U.S. [...]

Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. [...]

This review covers recent advances (2023-2024) in neuroimaging research into the pathophysiology, progression, and treatment of Alzheimer's disease (AD) and related dementias (ADRD). Despite the rapid emergence of blood-based biomarkers, neuroimaging continues to be a vital area of research in ADRD. [...]

This study investigated evidence for or against a difference in treatment effect between women and men for lecanemab and donanemab.Data were derived from supplementary analyses of the regulatory studies CLARITY-AD (lecanemab) and TRAILBLAZER-ALZ2 (donanemab). Bayes factor functions were used to analyze treatment effects on Clinical Dementia Rating Sum of Boxes (CDR-SB) scores.We found moderate evidence of a lower treatment effect in women than in men for lecanemab (maximum Bayes factor = 5.97), suggesting that the presence of an effect was almost six times more likely than the absence of an effect. [...]

Background. Combining Transcranial Electrical Stimulation and Visual Stimulation at the gamma frequency of 40 Hz holds scientific and clinical potential, but requires concurrent electrophysiological measurement to quantify neuronal effects. [...]

The protein neurofilament light chain in blood (bNfL) has become a valuable biomarker in the diagnosis, monitoring, and prognosis of neurological diseases. However, its potential use beyond neurology in routine clinical practice remains unexplored. [...]

Predictors for checkpoint inhibitor-related pneumonitis (cinrPneumonitis) are desperately needed. This study aimed to investigate the pretreatment standardized uptake value (SUV) on [18F]FDG-PET/CT of non-tumorous lung tissue as a predictive imaging marker for the development of cinrPneumonitis in 239 patients with lung cancer.All patients with lung cancer receiving [18F]Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) prior to immune checkpoint inhibitor (ICI) therapy were included and retrospectively analyzed. [...]

How does synaptic wiring depend on receptor clustering, scaffold networks, and signaling cohorts? In a recent study in Molecular Cell, Jia et al.1 demonstrate that targeting the interaction strength between the scaffold proteins, rather than the total amount of each protein component, modulates the signal propagation across the protein network..