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2023-03-22
14:16
DBCoverage [DZNE-2023-00373] Journal Article
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Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron.
iScience 26(4), 106323 () [10.1016/j.isci.2023.106323]
The recurrent emerging of novel viral variants of concern (VOCs) with evasion of preexisting antibody immunity upholds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case numbers and maintains a persistent demand for updated therapies. We selected the patient-derived antibody CV38-142 based on its potency and breadth against the VOCs Alpha, Beta, Gamma, and Delta for preclinical development into a therapeutic. [...]
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2023-03-22
14:12
DBCoverage [DZNE-2023-00372] Journal Article
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SARAspeech-Feasibility of automated assessment of ataxic speech disturbance.
npj digital medicine 6(1), 43 ()
Ataxias are a group of movement disorders that are characterized by progressive loss of balance, impaired coordination and speech disturbance, which together lead to markedly reduced quality of life. Speech disturbance is clinically diagnosed, but methods for objective assessment of severity are lacking. [...]
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2023-03-22
14:08

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2023-03-22
14:00
[DZNE-2023-00370] Journal Article
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A Residual Marker of Cognitive Reserve Is Associated with Resting-State Intrinsic Functional Connectivity Along the Alzheimer's Disease Continuum.
Journal of Alzheimer's disease Advance online publication, 1 - 16 () [10.3233/JAD-220464]
Cognitive reserve (CR) explains inter-individual differences in the impact of the neurodegenerative burden on cognitive functioning. A residual model was proposed to estimate CR more accurately than previous measures. [...]

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2023-03-22
13:49
[DZNE-2023-00369] Journal Article
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The interplay between micro RNAs and genetic liability to Alzheimer's Disease on memory trajectories in the general population.
Deficits in cognitive function and memory are common early symptoms of neurodegenerative disorders, such as Alzheimer's Disease (AD). Several studies have discussed micro RNAs (miRNAs) as potential epigenetic early detection biomarkers. [...]

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2023-03-22
13:48

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2023-03-22
13:38
[DZNE-2023-00367] Journal Article (Editorial)
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Adult neurogenesis in the hippocampus.
Hippocampus Advance online publication, n/a () [10.1002/hipo.23525]
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2023-03-22
13:36
[DZNE-2023-00366] Contribution to a conference proceedings/Contribution to a book
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Complex Network for Complex Problems: A comparative study of CNN and Complex-valued CNN
2022 IEEE 5th International Conference on Image Processing Applications and Systems (IPAS) : [Proceedings] - IEEE, 2022. - ISBN 978-1-6654-6219-8 - doi:10.1109/IPAS55744.2022.10053060
2022 IEEE 5th International Conference on Image Processing Applications and Systems (IPAS), GenovaGenova, Italy, 5 Dec 2022 - 7 Dec 20222022-12-052022-12-07
IEEE 1-5 () [10.1109/IPAS55744.2022.10053060]
Neural networks, especially convolutional neural networks (CNN), are one of the most common tools these days used in computer vision. Most of these networks work with real-valued data using real-valued features. [...]
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2023-03-22
13:29
[DZNE-2023-00365] Contribution to a conference proceedings/Contribution to a book
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Liver Segmentation in Time-resolved C-arm CT Volumes Reconstructed from Dynamic Perfusion Scans using Time Separation Technique
2022 IEEE 5th International Conference on Image Processing Applications and Systems (IPAS) : [Proceedings] - IEEE, 2022. - ISBN 978-1-6654-6219-8 - doi:10.1109/IPAS55744.2022.10052849
2022 IEEE 5th International Conference on Image Processing Applications and Systems (IPAS), GenovaGenova, Italy, 5 Dec 2022 - 7 Dec 20222022-12-052022-12-07
IEEE 1-7 () [10.1109/IPAS55744.2022.10052849]
Perfusion imaging is a valuable tool for diagnosing and treatment planning for liver tumours. The time separation technique (TST) has been successfully used for modelling C-arm cone-beam computed tomography (CBCT) perfusion data [...]
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2023-03-21
16:47
[DZNE-2023-00364] Preprint
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The impact of dance movement interventions on psychological health in older adults without dementia: A systematic review and meta-analysis
Multimodal lifestyle-based interventions that integrate physical, mental and social stimulation could promote mental health and brain resilience against dementia. This meta-analysis examined the efficacy of dance movement interventions (DMI) on psychological health in older adults. [...]
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