2026-05-22 16:43 |
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2026-05-22 16:39 |
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2026-05-22 16:33 |
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2026-05-22 16:32 |
[DZNE-2026-00549]
Journal Article
Klafki, H.-W. ; Derad, C. ; Hoberg, M. ; et al
Evaluation of fully automated ApoE4 proteotyping for APOE ε4 genotype estimation in the FINDERI cohort.
Carriers of the ε4 allele of the apolipoprotein E (APOE) gene have an increased risk for Alzheimer's disease (AD) and amyloid-related imaging abnormalities (ARIAs) upon anti-amyloid beta (Αβ) immunotherapy. Measuring apoE4 and pan-apoE proteins in blood plasma for apoE4 proteotyping may offer an alternative to APOE genotyping.We assessed apoE4 proteotyping accuracy in 479 participants of the prospective FINd DElirium RIsk factors (FINDERI) study in patients undergoing cardiac surgery and compared results to quantitative polymerase chain reaction (qPCR) genotyping.Proteotype-genotype discordance occurred in 8 of 479 participants (1.67%). [...]
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2026-05-22 16:31 |
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2026-05-22 15:14 |
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2026-05-20 12:44 |
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2026-05-20 12:40 |
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2026-05-20 12:38 |
[DZNE-2026-00542]
Journal Article
König, A. ; Tröger, J. ; Mallick, E. ; et al
Speech-based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts.
Early detection of Alzheimer's disease (AD) is critical for timely intervention as disease-modifying treatments emerge. Speech-based digital biomarkers offer scalable options for remotely capturing speech-derived functional changes associated with early cognitive decline, but validation across real-world populations remains limited.We evaluated the speech biomarker for cognition (SB-C), an automated speech-derived measure associated with cognitive status, in 736 participants across five European cohorts (Barcelonaβeta Brain Research Center's Alzheimer's at-risk cohort, European Prevention of Alzheimer's Dementia Scotland, Dementia Study of Cognitive and Biomarker Dynamics, Longitudinal Cognitive Impairment and Dementia Study, and Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably [BioFINDER-Primary Care]). [...]
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2026-05-20 12:34 |
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