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@ARTICLE{Nalls:155333,
author = {Nalls, Mike A and Bras, Jose and Hernandez, Dena G and
Keller, Margaux F and Majounie, Elisa and Renton, Alan E and
Saad, Mohamad and Jansen, Iris and Guerreiro, Rita and
Lubbe, Steven and Plagnol, Vincent and Gibbs, J Raphael and
Schulte, Claudia and Pankratz, Nathan and Sutherland,
Margaret and Bertram, Lars and Lill, Christina M and
DeStefano, Anita L and Faroud, Tatiana and Eriksson,
Nicholas and Tung, Joyce Y and Edsall, Connor and Nichols,
Noah and Brooks, Janet and Arepalli, Sampath and Pliner,
Hannah and Letson, Chris and Heutink, Peter and Martinez,
Maria and Gasser, Thomas and Traynor, Bryan J and Wood, Nick
and Hardy, John and Singleton, Andrew B and Nalls, Mike A
and Plagnol, Vincent and Hernandez, Dena G and Edsall,
Connor and Nichols, Noah and Sharma, Manu and Sheerin,
Una-Marie and Saad, Mohamad and Simón-Sánchez, Javier and
Schulte, Claudia and Lesage, Suzanne and
Sveinbjörnsdóttir, Sigurlaug and Arepalli, Sampath and
Barker, Roger and Ben-Shlomo, Yoav and Berendse, Henk W and
Berg, Daniela and Bhatia, Kailash and de Bie, Rob M A and
Biffi, Alessandro and Bloem, Bas and Bochdanovits, Zoltan
and Bonin, Michael and Bras, Jose M and Brockmann, Kathrin
and Brooks, Janet and Burn, David J and Charlesworth, Gavin
and Chen, Honglei and Chinnery, Patrick F and Chong, Sean
and Clarke, Carl E and Cookson, Mark R and Cooper, J Mark
and Corvol, Jean Christophe and Counsell, Carl and Damier,
Philippe and Dartigues, Jean-François and Deloukas, Panos
and Deuschl, Günther and Dexter, David T and van Dijk,
Karin D and Dillman, Allissa and Durif, Frank and Dürr,
Alexandra and Edkins, Sarah and Evans, Jonathan R and
Foltynie, Thomas and Dong, Jing and Gardner, Michelle and
Gibbs, J Raphael and Goate, Alison and Gray, Emma and
Guerreiro, Rita and Harris, Clare and van Hilten, Jacobus J
and Hofman, Albert and Hollenbeck, Albert and Holton, Janice
and Hu, Michele and Huang, Xuemei and Wurster, Isabel and
Mätzler, Walter and Hudson, Gavin and Hunt, Sarah E and
Huttenlocher, Johanna and Illig, Thomas and Jónsson, Pálmi
V and Lambert, Jean-Charles and Langford, Cordelia and Lees,
Andrew and Lichtner, Peter and Limousin, Patricia and Lopez,
Grisel and Lorenz, Delia and Lubbe, Steven and McNeill,
Alisdair and Moorby, Catriona and Moore, Matthew and Morris,
Huw R and Morrison, Karen E and O'Sullivan, Sean S and
Pearson, Justin and Perlmutter, Joel S and Pétursson,
Hjörvar and Pollak, Pierre and Post, Bart and Potter, Simon
and Ravina, Bernard and Revesz, Tamas and Riess, Olaf and
Rivadeneira, Fernando and Rizzu, Patrizia and Ryten, Mina
and Sawcer, Stephen and Schapira, Anthony and Scheffer, Hans
and Shaw, Karen and Shoulson, Ira and Sidransky, Ellen and
Smith, Colin and Spencer, Chris C A and Stefánsson, Hreinn
and Bettella, Francesco and Stockton, Joanna D and Strange,
Amy and Talbot, Kevin and Tanner, Carlie M and
Tashakkori-Ghanbaria, Avazeh and Tison, François and
Trabzuni, Daniah and Traynor, Bryan J and Uitterlinden,
André G and Velseboer, Daan and Vidailhet, Marie and
Walker, Robert and van de Warrenburg, Bart and
Wickremaratchi, Mirdhu and Williams, Nigel and
Williams-Gray, Caroline H and Winder-Rhodes, Sophie and
Stefánsson, Kári and Martinez, Maria and Wood, Nicholas W
and Hardy, John and Heutink, Peter and Brice, Alexis and
Gasser, Thomas and Singleton, Andrew B and Renton, Alan E
and Nichols, Noah and Brooks, Janet and Arepalli, Sampath
and Pilner, Hannah and Letson, Chris and Traynor, Bryan J
and Factor, S. and Higgins, D. and Evans, S. and Shill, H.
and Stacy, M. and Danielson, J. and Marlor, L. and
Williamson, K. and Jankovic, J. and Hunter, C. and Simon, D.
and Ryan, P. and Scollins, L. and Saunders-Pullman, R. and
Boyar, K. and Costan-Toth, C. and Ohmann, E. and Sudarsky,
L. and Joubert, C. and Friedman, J. and Chou, K. and
Fernandez, H. and Lannon, M. and Galvez-Jimenez, N. and
Podichetty, A. and Thompson, K. and Lewitt, P. and
DeAngelis, M. and O'Brien, C. and Seeberger, L. and
Dingmann, C. and Judd, D. and Marder, K. and Fraser, J. and
Harris, J. and Bertoni, J. and Peterson, C. and Rezak, M.
and Medalle, G. and Chouinard, S. and Panisset, M. and Hall,
J. and Poiffaut, H. and Calabrese, V. and Roberge, P. and
Wojcieszek, J. and Belden, J. and Jennings, D. and Marek, K.
and Mendick, S. and Reich, S. and Dunlop, B. and Jog, M. and
Horn, C. and Uitti, R. and Turk, M. and Ajax, T. and
Mannetter, J. and Sethi, K. and Carpenter, J. and Dill, B.
and Hatch, L. and Ligon, K. and Narayan, S. and Blindauer,
K. and Abou-Samra, K. and Petit, J. and Elmer, L. and Aiken,
E. and Davis, K. and Schell, C. and Wilson, S. and
Velickovic, M. and Koller, W. and Phipps, S. and Feigin, A.
and Gordon, M. and Hamann, J. and Licari, E. and
Marotta-Kollarus, M. and Shannon, B. and Winnick, R. and
Simuni, T. and Videnovic, A. and Kaczmarek, A. and Williams,
K. and Wolff, M. and Rao, J. and Cook, M. and Fernandez, M.
and Kostyk, S. and Hubble, J. and Campbell, A. and Reider,
C. and Seward, A. and Camicioli, R. and Carter, J. and Nutt,
J. and Andrews, P. and Morehouse, S. and Stone, C. and
Mendis, T. and Grimes, D. and Alcorn-Costa, C. and Gray, P.
and Haas, K. and Vendette, J. and Sutton, J. and Hutchinson,
B. and Young, J. and Rajput, A. and Klassen, L. and Shirley,
T. and Manyam, B. and Simpson, P. and Whetteckey, J. and
Wulbrecht, B. and Truong, D. and Pathak, M. and Frei, K. and
Luong, N. and Tra, T. and Tran, Thanh-Phuong and Vo, J. and
Lang, Johannes D. and Kleiner-Fisman, G. and Nieves, A. and
Johnston, L. and So, J. and Podskalny, G. and Giffin, L. and
Atchison, P. and Allen, C. and Martin, W. and Wieler, M. and
Suchowersky, O. and Furtado, S. and Klimek, M. and
Hermanowicz, N. and Niswonger, S. and Shults, C. and
Fontaine, D. and Aminoff, M. and Christine, C. and Diminno,
M. and Hevezi, J. and Dalvi, A. and Kang, U. and Richman, J.
and Uy, S. and Young, J. and Dalvi, A. and Sahay, A. and
Gartner, M. and Schwieterman, D. and Hall, D. and Leehey, M.
and Culver, S. and Derian, T. and Demarcaida, T. and
Thurlow, S. and Rodnitzky, R. and Dobson, J. and Lyons, K.
and Pahwa, R. and Gales, T. and Thomas, S. and Shulman, L.
and Reich, S. and Weiner, W. and Dustin, K. and Lyons, K.
and Singer, C. and Koller, W. and Weiner, W. and Zelaya, L.
and Tuite, P. and Hagen, V. and Rolandelli, S. and
Schacherer, R. and Kosowicz, J. and Gordon, P. and Werner,
J. and Serrano, C. and Roque, S. and Kurlan, R. and Berry,
D. and Gardiner, I. and Hauser, R. and Sanchez-Ramos, J. and
Zesiewicz, T. and Delgado, H. and Price, K. and Rodriguez,
P. and Wolfrath, S. and Pfeiffer, R. and Davis, L. and
Pfeiffer, B. and Dewey, R. and Hayward, B. and Johnson, A.
and Meacham, M. and Estes, B. and Walker, F. and Hunt, V.
and O'Neill, C. and Racette, B. and Swisher, L. and
Eriksson, Nicholas and Dijamco, Cheri and Drabant, Emily M
and Dorfman, Elizabeth and Tung, Joyce Y and Hinds, David A
and Mountain, Joanna L and Wojcicki, Anne and Lill,
Christina and Bertram, Lars and Lew, M. and Suchowersky, O.
and Klein, Christina and Golbe, L. and Mark, M. H. and
Growdon, J. and Huggins, N. and Wooten, G. F. and Watts, R.
and Guttman, M. and Racette, B. and Perlmutter, J. and
Marlor, L. and Shill, H. and Singer, C. and Goldwurm, S. and
Pezzoli, G. and Saint-Hilaire, M. H. and Massood, T. and
Baker, K. and Itin, I. and Litvan, I. and Nicholson, G. and
Corbett, A. and Nance, M. and Drasby, E. and Isaacson, S.
and Burn, D. and Chinnery, P. and Pramstaller, P. and
Al-hinti, J. and Möller, Anke and Ostergaard, K. and
Sherman, S. and Roxburgh, R. and Snow, B. and Slevin, J. and
Cambi, F. and Kay, D. and Montimurro, J. and Kusel, V. and
Samii, A. and Martinez, E. and Yearout, D. and Nutt, J. and
Agarwal, P. and Griffith, A. and Roberts, J. W. and Higgins,
D. S. and Molho, Eric and Rosen, Ami and Clark, L. N. and
Liu, X. and Lee, J. H. and Cheng, R. and Marder, K. and
Louis, E. D. and Cote, L. J. and Waters, C. and Ford, B. and
Fahn, S. and Vance, Jeffery M and Beecham, Gary W and
Martin, Eden R and Nuytemans, Karen and Pericak-Vance,
Margaret A and Haines, Jonathan L and DeStefano, Anita and
Seshadri, Sudha and Choi, Seung Hoan and Frank, Samuel and
Bis, Joshua C and Psaty, Bruce M and Rice, Kenneth and
Longstreth, W. T. and Ton, Thanh G N and Jain, Samay and
Ikram, M Arfan and van Duijn, Cornelia M and Hofman, Albert
and Uitterlinden, Andre and Verlinden, Vincent and
Koudstaal, Peter J and Kara, Eleanna and Xiromerisiou,
Georgia and Dardiotis, Efthimios and Tsimourtou, Vana and
Spanaki, Cleanthe and Plaitakis, Andreas and Bozi, Maria and
Stefanis, Leonidas and Vassilatis, Dimitris and Koutsis,
Georgios and Panas, Marios and Houlden, Henry and
Hadjigeorgiou, Georgios M and Guerreiro, Rita and Bras, Jose
and Lunnon, Katie and Lupton, Michelle and Powell, John and
Parkkinen, Laura and Ansorge, Olaf and Hardy, John},
collaboration = {Consortium, International Parkinson's Disease Genomics and
consortium, Parkinson's Disease meta-analysis},
title = {{N}euro{X}, a fast and efficient genotyping platform for
investigation of neurodegenerative diseases.},
journal = {Neurobiology of aging},
volume = {36},
number = {3},
issn = {0197-4580},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {DZNE-2021-00600},
pages = {1605.e7 - 1605.e12},
year = {2015},
abstract = {Our objective was to design a genotyping platform that
would allow rapid genetic characterization of samples in the
context of genetic mutations and risk factors associated
with common neurodegenerative diseases. The platform needed
to be relatively affordable, rapid to deploy, and use a
common and accessible technology. Central to this project,
we wanted to make the content of the platform open to any
investigator without restriction. In designing this array we
prioritized a number of types of genetic variability for
inclusion, such as known risk alleles, disease-causing
mutations, putative risk alleles, and other functionally
important variants. The array was primarily designed to
allow rapid screening of samples for disease-causing
mutations and large population studies of risk factors.
Notably, an explicit aim was to make this array widely
available to facilitate data sharing across and within
diseases. The resulting array, NeuroX, is a remarkably cost
and time effective solution for high-quality genotyping.
NeuroX comprises a backbone of standard Illumina exome
content of approximately 240,000 variants, and over 24,000
custom content variants focusing on neurologic diseases.
Data are generated at approximately $50-$60 per sample using
a 12-sample format chip and regular Infinium infrastructure;
thus, genotyping is rapid and accessible to many
investigators. Here, we describe the design of NeuroX,
discuss the utility of NeuroX in the analyses of rare and
common risk variants, and present quality control metrics
and a brief primer for the analysis of NeuroX derived data.},
keywords = {Alleles / Costs and Cost Analysis / Genetic Association
Studies: methods / Genetic Predisposition to Disease:
genetics / Genetic Variation / Genotyping Techniques:
economics / Genotyping Techniques: methods /
Neurodegenerative Diseases: genetics / Oligonucleotide Array
Sequence Analysis: methods / Genetics (Other) / Genotyping
(Other) / Imputation (Other) / Meta-analysis (Other) /
Methods (Other) / Neurodegeneration (Other) / Parkinson's
(Other)},
ddc = {610},
pnm = {899 - ohne Topic (POF4-899)},
pid = {G:(DE-HGF)POF4-899},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:25444595},
pmc = {pmc:PMC4317375},
doi = {10.1016/j.neurobiolaging.2014.07.028},
url = {https://pub.dzne.de/record/155333},
}
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