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000269683 041__ $$aItalian
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000269683 1001_ $$00000-0003-0647-172X$$aPasternak, Maurice$$b0
000269683 245__ $$aLongitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results.
000269683 260__ $$aHoboken, NJ$$bWiley$$c2024
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000269683 520__ $$aEffective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We investigate the utility of cerebral perfusion as one such biomarker in presymptomatic FTD mutation carriers.We investigated longitudinal profiles of cerebral perfusion using arterial spin labeling magnetic resonance imaging in 42 C9orf72, 70 GRN, and 31 MAPT presymptomatic carriers and 158 non-carrier controls. Linear mixed effects models assessed perfusion up to 5 years after baseline assessment.Perfusion decline was evident in all three presymptomatic groups in global gray matter. Each group also featured its own regional pattern of hypoperfusion over time, with the left thalamus common to all groups. Frontal lobe regions featured lower perfusion in those who symptomatically converted versus asymptomatic carriers past their expected age of disease onset.Cerebral perfusion is a potential biomarker for assessing genetic FTD and its genetic subgroups prior to symptom onset.Gray matter perfusion declines in at-risk genetic frontotemporal dementia (FTD). Regional perfusion decline differs between at-risk genetic FTD subgroups . Hypoperfusion in the left thalamus is common across all presymptomatic groups. Converters exhibit greater right frontal hypoperfusion than non-converters past their expected conversion date. Cerebral hypoperfusion is a potential early biomarker of genetic FTD.
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000269683 650_7 $$2Other$$aarterial spin labeling
000269683 650_7 $$2Other$$acerebral perfusion
000269683 650_7 $$2Other$$afrontotemporal dementia
000269683 650_7 $$2Other$$apresymptomatic biomarker
000269683 650_2 $$2MeSH$$aHumans
000269683 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000269683 650_2 $$2MeSH$$aFrontotemporal Dementia: physiopathology
000269683 650_2 $$2MeSH$$aFrontotemporal Dementia: diagnostic imaging
000269683 650_2 $$2MeSH$$aFemale
000269683 650_2 $$2MeSH$$aMale
000269683 650_2 $$2MeSH$$aMiddle Aged
000269683 650_2 $$2MeSH$$aLongitudinal Studies
000269683 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000269683 650_2 $$2MeSH$$aCerebrovascular Circulation: physiology
000269683 650_2 $$2MeSH$$aCerebrovascular Circulation: genetics
000269683 650_2 $$2MeSH$$aC9orf72 Protein: genetics
000269683 650_2 $$2MeSH$$atau Proteins: genetics
000269683 650_2 $$2MeSH$$aGray Matter: diagnostic imaging
000269683 650_2 $$2MeSH$$aGray Matter: pathology
000269683 650_2 $$2MeSH$$aProgranulins: genetics
000269683 650_2 $$2MeSH$$aBiomarkers
000269683 650_2 $$2MeSH$$aDisease Progression
000269683 650_2 $$2MeSH$$aBrain: diagnostic imaging
000269683 650_2 $$2MeSH$$aHeterozygote
000269683 650_2 $$2MeSH$$aMutation
000269683 650_2 $$2MeSH$$aAged
000269683 650_2 $$2MeSH$$aSpin Labels
000269683 650_2 $$2MeSH$$aAdult
000269683 7001_ $$aMirza, Saira S$$b1
000269683 7001_ $$aLuciw, Nicholas$$b2
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000269683 7001_ $$aBorroni, Barbara$$b21
000269683 7001_ $$aGalimberti, Daniela$$b22
000269683 7001_ $$aRowe, James B$$b23
000269683 7001_ $$aGraff, Caroline$$b24
000269683 7001_ $$aFinger, Elizabeth$$b25
000269683 7001_ $$aSorbi, Sandro$$b26
000269683 7001_ $$ade Mendonça, Alexandre$$b27
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000269683 7001_ $$aMoreno, Fermin$$b31
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000269683 7001_ $$aMacIntosh, Bradley J$$b39
000269683 7001_ $$aRohrer, Jonathan D$$b40
000269683 7001_ $$aMasellis, Mario$$b41
000269683 7001_ $$aInitiative, GENetic Frontotemporal dementia$$b42$$eCollaboration Author
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000269683 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.13750$$gVol. 20, no. 5, p. 3525 - 3542$$n5$$p3525 - 3542$$tAlzheimer's and dementia$$v20$$x1552-5260$$y2024
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