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@ARTICLE{Pasternak:269683,
      author       = {Pasternak, Maurice and Mirza, Saira S and Luciw, Nicholas
                      and Mutsaerts, Henri J M M and Petr, Jan and Thomas, David
                      and Cash, David and Bocchetta, Martina and Tartaglia, Maria
                      Carmela and Mitchell, Sara B and Black, Sandra E and
                      Freedman, Morris and Tang-Wai, David and Rogaeva, Ekaterina
                      and Russell, Lucy L and Bouzigues, Arabella and van Swieten,
                      John C and Jiskoot, Lize C and Seelaar, Harro and Laforce,
                      Robert and Tiraboschi, Pietro and Borroni, Barbara and
                      Galimberti, Daniela and Rowe, James B and Graff, Caroline
                      and Finger, Elizabeth and Sorbi, Sandro and de Mendonça,
                      Alexandre and Butler, Chris and Gerhard, Alex and
                      Sanchez-Valle, Raquel and Moreno, Fermin and Synofzik,
                      Matthis and Vandenberghe, Rik and Ducharme, Simon and Levin,
                      Johannes and Otto, Markus and Santana, Isabel and Strafella,
                      Antonio P and MacIntosh, Bradley J and Rohrer, Jonathan D
                      and Masellis, Mario},
      collaboration = {Initiative, GENetic Frontotemporal dementia},
      othercontributors = {Nelson, Annabel and Bocchetta, Martina and Cash, David and
                          Thomas, David L and Todd, Emily and Benotmane, Hanya and
                          Nicholas, Jennifer and Samra, Kiran and Shafei, Rachelle and
                          Timberlake, Carolyn and Cope, Thomas and Rittman, Timothy
                          and Benussi, Alberto and Premi, Enrico and Gasparotti,
                          Roberto and Archetti, Silvana and Gazzina, Stefano and
                          Arighi, Andrea and Fenoglio, Chiara and Scarpini, Elio and
                          Fumagalli, Giorgio and Borracci, Vittoria and Rossi,
                          Giacomina and Giaccone, Giorgio and Fede, Giuseppe Di and
                          Caroppo, Paola and Tiraboschi, Pietro and Prioni, Sara and
                          Redaelli, Veronica and Tang-Wai, David and Rogaeva,
                          Ekaterina and Castelo-Branco, Miguel and Freedman, Morris
                          and Keren, Ron and Black, Sandra and Mitchell, Sara and
                          Shoesmith, Christen and Bartha, Robart and Rademakers, Rosa
                          and Poos, Jackie and Papma, Janne M and Giannini, Lucia and
                          van Minkelen, Rick and Pijnenburg, Yolande and Nacmias,
                          Benedetta and Ferrari, Camilla and Polito, Cristina and
                          Lombardi, Gemma and Bessi, Valentina and Veldsman, Michele
                          and Andersson, Christin and Thonberg, Hakan and Öijerstedt,
                          Linn and Jelic, Vesna and Thompson, Paul and Langheinrich,
                          Tobias and Lladó, Albert and Antonell, Anna and Olives,
                          Jaume and Balasa, Mircea and Bargalló, Nuria and
                          Borrego-Ecija, Sergi and Verdelho, Ana and Maruta, Carolina
                          and Ferreira, Catarina B and Miltenberger, Gabriel and
                          Simões do Couto, Frederico and Gabilondo, Alazne and
                          Gorostidi, Ana and Villanua, Jorge and Cañada, Marta and
                          Tainta, Mikel and Zulaica, Miren and Barandiaran, Myriam and
                          Alves, Patricia and Bender, Benjamin and Wilke, Carlo and
                          Graf, Lisa and Vogels, Annick and Vandenbulcke, Mathieu and
                          Van Damme, Philip and Bruffaerts, Rose and Poesen, Koen and
                          Rosa-Neto, Pedro and Gauthier, Serge and Camuzat, Agnès and
                          Brice, Alexis and Bertrand, Anne and Funkiewiez, Aurélie
                          and Rinaldi, Daisy and Saracino, Dario and Colliot, Olivier
                          and Sayah, Sabrina and Prix, Catharina and Wlasich,
                          Elisabeth and Wagemann, Olivia and Loosli, Sandra and
                          Schönecker, Sonja and Hoegen, Tobias and Lombardi, Jolina
                          and Anderl-Straub, Sarah and Rollin, Adeline and Kuchcinski,
                          Gregory and Bertoux, Maxime and Lebouvier, Thibaud and
                          Deramecourt, Vincent and Santiago, Beatriz and Duro, Diana
                          and João Leitão, Maria and Almeida, Maria Rosario and
                          Tábuas-Pereira, Miguel and Afonso, Sónia},
      title        = {{L}ongitudinal cerebral perfusion in presymptomatic genetic
                      frontotemporal dementia: {GENFI} results.},
      journal      = {Alzheimer's and dementia},
      volume       = {20},
      number       = {5},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-00597},
      pages        = {3525 - 3542},
      year         = {2024},
      abstract     = {Effective longitudinal biomarkers that track disease
                      progression are needed to characterize the presymptomatic
                      phase of genetic frontotemporal dementia (FTD). We
                      investigate the utility of cerebral perfusion as one such
                      biomarker in presymptomatic FTD mutation carriers.We
                      investigated longitudinal profiles of cerebral perfusion
                      using arterial spin labeling magnetic resonance imaging in
                      42 C9orf72, 70 GRN, and 31 MAPT presymptomatic carriers and
                      158 non-carrier controls. Linear mixed effects models
                      assessed perfusion up to 5 years after baseline
                      assessment.Perfusion decline was evident in all three
                      presymptomatic groups in global gray matter. Each group also
                      featured its own regional pattern of hypoperfusion over
                      time, with the left thalamus common to all groups. Frontal
                      lobe regions featured lower perfusion in those who
                      symptomatically converted versus asymptomatic carriers past
                      their expected age of disease onset.Cerebral perfusion is a
                      potential biomarker for assessing genetic FTD and its
                      genetic subgroups prior to symptom onset.Gray matter
                      perfusion declines in at-risk genetic frontotemporal
                      dementia (FTD). Regional perfusion decline differs between
                      at-risk genetic FTD subgroups . Hypoperfusion in the left
                      thalamus is common across all presymptomatic groups.
                      Converters exhibit greater right frontal hypoperfusion than
                      non-converters past their expected conversion date. Cerebral
                      hypoperfusion is a potential early biomarker of genetic
                      FTD.},
      keywords     = {Humans / Frontotemporal Dementia: genetics / Frontotemporal
                      Dementia: physiopathology / Frontotemporal Dementia:
                      diagnostic imaging / Female / Male / Middle Aged /
                      Longitudinal Studies / Magnetic Resonance Imaging /
                      Cerebrovascular Circulation: physiology / Cerebrovascular
                      Circulation: genetics / C9orf72 Protein: genetics / tau
                      Proteins: genetics / Gray Matter: diagnostic imaging / Gray
                      Matter: pathology / Progranulins: genetics / Biomarkers /
                      Disease Progression / Brain: diagnostic imaging /
                      Heterozygote / Mutation / Aged / Spin Labels / Adult /
                      arterial spin labeling (Other) / cerebral perfusion (Other)
                      / frontotemporal dementia (Other) / presymptomatic biomarker
                      (Other)},
      ddc          = {610},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38623902},
      pmc          = {pmc:PMC11095434},
      doi          = {10.1002/alz.13750},
      url          = {https://pub.dzne.de/record/269683},
}