TY  - JOUR
AU  - Bartrés-Faz, David
AU  - Demnitz-King, Harriet
AU  - Cabello-Toscano, María
AU  - Vaqué-Alcázar, Lídia
AU  - Saunders, Rob
AU  - Touron, Edelweiss
AU  - Cattaneo, Gabriele
AU  - Gonneaud, Julie
AU  - Klimecki-Lenz, Olga Maria
AU  - Bargalló, Núria
AU  - Sánchez-Solana, Javier
AU  - Tormos, José M.
AU  - Chételat, Gäel
AU  - Pascual-Leone, Álvaro
AU  - Marchant, Natalie L.
AU  - André, Claire
AU  - Bachelet, Romain
AU  - Baez Lugo, Sebastian
AU  - Chocat, Anne
AU  - Collette, Fabienne
AU  - Coll-Padros, Nina
AU  - Dautricourt, Sophie
AU  - De La Sayette, Vincent
AU  - Delarue, Marion
AU  - Ferrand Devouge, Eglantine
AU  - Frison, Eric
AU  - Goldet, Karine
AU  - Jessen, Frank
AU  - Krolak-Salmon, Pierre
AU  - Kuhn, Elizabeth
AU  - Landeau, Brigitte
AU  - Lefranc, Valérie
AU  - Lutz, Antoine
AU  - Mezenge, Florence
AU  - Meiberth, Dix
AU  - Michel, Laurence
AU  - Molinuevo, José Luis
AU  - Ourry, Valentin
AU  - Poisnel, Géraldine
AU  - Quillard, Anne
AU  - Rauchs, Géraldine
AU  - Salmon, Eric
AU  - Schild, Ann-Katrin
AU  - Schimmer, Corinne
AU  - Smagghe, Delphine
AU  - Smith, Rhonda
AU  - Schlosser, Marco
AU  - Vuilleumier, Patrik
AU  - Wallet, Cédrick
AU  - Walker, Zuzana
AU  - Whitfield, Tim
AU  - Wirth, Miranka
TI  - Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults
JO  - Nature Mental Health
VL  - 3
IS  - 1
SN  - 2731-6076
CY  - London
PB  - Nature Publishing Group UK
M1  - DZNE-2025-00712
SP  - 92 - 103
PY  - 2025
AB  - Psychological characteristics are associated with varying dementia risk and protective factors. To determine whether these characteristics aggregate into psychological profiles and whether these profiles differentially relate to aging health, we conducted a cross-sectional investigation in two independent middle-aged (51.4 ± 7.0 years (mean ± s.d.); N = 750) and older adult (71.1 ± 5.9 years; N = 282) cohorts, supplemented by longitudinal analyses in the former. Using a person-centered approach, three profiles emerged in both cohorts: those with low protective characteristics (profile 1), high risk characteristics (profile 2) and well-balanced characteristics (profile 3). Profile 1 showed the worst objective cognition in older age and middle age (at follow-up), and most rapid cortical thinning. Profile 2 exhibited the worst mental health symptomology and lowest sleep quality in both older age and middle age. We identified profile-dependent divergent patterns of associations that may suggest two distinct paths for mental, cognitive and brain health, emphasizing the need for comprehensive psychological assessments in dementia prevention research to identify groups for more personalized behavior-change strategies.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1038/s44220-024-00361-8
UR  - https://pub.dzne.de/record/279184
ER  -