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@ARTICLE{BartrsFaz:279184,
      author       = {Bartrés-Faz, David and Demnitz-King, Harriet and
                      Cabello-Toscano, María and Vaqué-Alcázar, Lídia and
                      Saunders, Rob and Touron, Edelweiss and Cattaneo, Gabriele
                      and Gonneaud, Julie and Klimecki-Lenz, Olga Maria and
                      Bargalló, Núria and Sánchez-Solana, Javier and Tormos,
                      José M. and Chételat, Gäel and Pascual-Leone, Álvaro and
                      Marchant, Natalie L. and André, Claire and Bachelet, Romain
                      and Baez Lugo, Sebastian and Chocat, Anne and Collette,
                      Fabienne and Coll-Padros, Nina and Dautricourt, Sophie and
                      De La Sayette, Vincent and Delarue, Marion and Ferrand
                      Devouge, Eglantine and Frison, Eric and Goldet, Karine and
                      Jessen, Frank and Krolak-Salmon, Pierre and Kuhn, Elizabeth
                      and Landeau, Brigitte and Lefranc, Valérie and Lutz,
                      Antoine and Mezenge, Florence and Meiberth, Dix and Michel,
                      Laurence and Molinuevo, José Luis and Ourry, Valentin and
                      Poisnel, Géraldine and Quillard, Anne and Rauchs,
                      Géraldine and Salmon, Eric and Schild, Ann-Katrin and
                      Schimmer, Corinne and Smagghe, Delphine and Smith, Rhonda
                      and Schlosser, Marco and Vuilleumier, Patrik and Wallet,
                      Cédrick and Walker, Zuzana and Whitfield, Tim and Wirth,
                      Miranka},
      title        = {{P}sychological profiles associated with mental, cognitive
                      and brain health in middle-aged and older adults},
      journal      = {Nature Mental Health},
      volume       = {3},
      number       = {1},
      issn         = {2731-6076},
      address      = {London},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2025-00712},
      pages        = {92 - 103},
      year         = {2025},
      abstract     = {Psychological characteristics are associated with varying
                      dementia risk and protective factors. To determine whether
                      these characteristics aggregate into psychological profiles
                      and whether these profiles differentially relate to aging
                      health, we conducted a cross-sectional investigation in two
                      independent middle-aged (51.4 ± 7.0 years (mean ± s.d.);
                      N = 750) and older adult (71.1 ± 5.9 years;
                      N = 282) cohorts, supplemented by longitudinal analyses
                      in the former. Using a person-centered approach, three
                      profiles emerged in both cohorts: those with low protective
                      characteristics (profile 1), high risk characteristics
                      (profile 2) and well-balanced characteristics (profile 3).
                      Profile 1 showed the worst objective cognition in older age
                      and middle age (at follow-up), and most rapid cortical
                      thinning. Profile 2 exhibited the worst mental health
                      symptomology and lowest sleep quality in both older age and
                      middle age. We identified profile-dependent divergent
                      patterns of associations that may suggest two distinct paths
                      for mental, cognitive and brain health, emphasizing the need
                      for comprehensive psychological assessments in dementia
                      prevention research to identify groups for more personalized
                      behavior-change strategies.},
      ddc          = {610},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1038/s44220-024-00361-8},
      url          = {https://pub.dzne.de/record/279184},
}