000284080 001__ 284080
000284080 005__ 20260126111626.0
000284080 0247_ $$2doi$$a10.1038/s44321-024-00093-3
000284080 0247_ $$2ISSN$$a1757-4676
000284080 0247_ $$2ISSN$$a1715-4684
000284080 0247_ $$2ISSN$$a1757-4684
000284080 037__ $$aDZNE-2026-00088
000284080 041__ $$aEnglish
000284080 082__ $$a610
000284080 1001_ $$00000-0002-9900-3214$$aHawwari, Ibrahim$$b0
000284080 245__ $$aPlatelet transcription factors license the pro-inflammatory cytokine response of human monocytes
000284080 260__ $$a[London]$$bNature Publishing Group UK$$c2024
000284080 3367_ $$2DRIVER$$aarticle
000284080 3367_ $$2DataCite$$aOutput Types/Journal article
000284080 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1769422300_1864
000284080 3367_ $$2BibTeX$$aARTICLE
000284080 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000284080 3367_ $$00$$2EndNote$$aJournal Article
000284080 520__ $$aIn humans, blood Classical CD14+ monocytes contribute to host defense by secreting large amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation and life-threatening cytokine storms, while dysfunctional monocytes are associated with 'immunoparalysis', a state of immune hypo responsiveness and reduced pro-inflammatory gene expression, predisposing individuals to opportunistic infections. Understanding how monocyte functions are regulated is critical to prevent these harmful outcomes. We reveal platelets' vital role in the pro-inflammatory cytokine responses of human monocytes. Naturally low platelet counts in patients with immune thrombocytopenia or removal of platelets from healthy monocytes result in monocyte immunoparalysis, marked by impaired cytokine response to immune challenge and weakened host defense transcriptional programs. Remarkably, supplementing monocytes with fresh platelets reverses these conditions. We discovered that platelets serve as reservoirs of key cytokine transcription regulators, such as NF-κB and MAPK p38, and pinpointed the enrichment of platelet NF-κB2 in human monocytes by proteomics. Platelets proportionally restore impaired cytokine production in human monocytes lacking MAPK p38α, NF-κB p65, and NF-κB2. We uncovered a vesicle-mediated platelet-monocyte-propagation of inflammatory transcription regulators, positioning platelets as central checkpoints in monocyte inflammation.
000284080 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x0
000284080 588__ $$aDataset connected to CrossRef, Journals: pub.dzne.de
000284080 650_7 $$2Other$$aHyperinflammation
000284080 650_7 $$2Other$$aImmune Thrombocytopenia
000284080 650_7 $$2Other$$aImmunoparalysis
000284080 650_7 $$2Other$$aInflammasomes
000284080 650_7 $$2Other$$aToll-like Receptors
000284080 650_7 $$2NLM Chemicals$$aCytokines
000284080 650_7 $$2NLM Chemicals$$aTranscription Factors
000284080 650_2 $$2MeSH$$aHumans
000284080 650_2 $$2MeSH$$aMonocytes: metabolism
000284080 650_2 $$2MeSH$$aMonocytes: immunology
000284080 650_2 $$2MeSH$$aBlood Platelets: metabolism
000284080 650_2 $$2MeSH$$aBlood Platelets: immunology
000284080 650_2 $$2MeSH$$aCytokines: metabolism
000284080 650_2 $$2MeSH$$aTranscription Factors: metabolism
000284080 650_2 $$2MeSH$$aTranscription Factors: genetics
000284080 650_2 $$2MeSH$$aInflammation: metabolism
000284080 7001_ $$aRossnagel, Lukas$$b1
000284080 7001_ $$aRosero, Nathalia$$b2
000284080 7001_ $$00000-0002-4615-7252$$aMaasewerd, Salie$$b3
000284080 7001_ $$aVasconcelos, Matilde B$$b4
000284080 7001_ $$aJentzsch, Marius$$b5
000284080 7001_ $$00000-0001-9868-7653$$aDemczuk, Agnieszka$$b6
000284080 7001_ $$aTeichmann, Lino L$$b7
000284080 7001_ $$aMeffert, Lisa$$b8
000284080 7001_ $$00000-0002-9495-706X$$aBertheloot, Damien$$b9
000284080 7001_ $$0P:(DE-2719)9001782$$aSecchim Ribeiro, Lucas$$b10$$udzne
000284080 7001_ $$aKallabis, Sebastian$$b11
000284080 7001_ $$aMeissner, Felix$$b12
000284080 7001_ $$00000-0001-9042-2909$$aArditi, Moshe$$b13
000284080 7001_ $$aAtici, Asli E$$b14
000284080 7001_ $$00000-0001-5570-8928$$aNoval Rivas, Magali$$b15
000284080 7001_ $$aFranklin, Bernardo S$$b16
000284080 773__ $$0PERI:(DE-600)2485479-7$$a10.1038/s44321-024-00093-3$$gVol. 16, no. 8, p. 1901 - 1929$$n8$$p1901 - 1929$$tEMBO molecular medicine$$v16$$x1757-4676$$y2024
000284080 8564_ $$uhttps://pub.dzne.de/record/284080/files/DZNE-2026-00088.pdf$$yOpenAccess
000284080 8564_ $$uhttps://pub.dzne.de/record/284080/files/DZNE-2026-00088.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000284080 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001782$$aExternal Institute$$b10$$kExtern
000284080 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000284080 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-28
000284080 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-28
000284080 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-28
000284080 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-28
000284080 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000284080 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bEMBO MOL MED : 2022$$d2024-12-28
000284080 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bEMBO MOL MED : 2022$$d2024-12-28
000284080 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2024-12-28$$wger
000284080 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-02-14T13:51:27Z
000284080 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-02-14T13:51:27Z
000284080 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-28
000284080 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2024-12-28
000284080 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-28
000284080 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000284080 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review, Double anonymous peer review$$d2024-02-14T13:51:27Z
000284080 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2024-12-28
000284080 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-28
000284080 915__ $$0StatID:(DE-HGF)10000$$2StatID$$aHosted Content
000284080 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-28
000284080 920__ $$lyes
000284080 980__ $$ajournal
000284080 980__ $$aI:(DE-2719)1040260
000284080 9801_ $$aUNRESTRICTED
000284080 9801_ $$aEXTERN4VITA
000284080 9801_ $$aFullTexts