TY  - JOUR
AU  - Secchim Ribeiro, Lucas
AU  - Migliari Branco, Laura
AU  - Franklin, Bernardo S.
TI  - Regulation of Innate Immune Responses by Platelets
JO  - Frontiers in immunology
VL  - 10
SN  - 1664-3224
CY  - Lausanne
PB  - Frontiers Media
M1  - DZNE-2026-00095
SP  - 1320
PY  - 2019
AB  - The role of platelets has been extensively studied in the context of coagulation and vascular integrity. Their hemostatic imbalance can lead to known conditions as atherosclerotic plaques, thrombosis, and ischemia. Nevertheless, the knowledge regarding the regulation of different cell types by platelets has been growing exponentially in the past years. Among these biological systems, the innate immune response is remarkably affected by the crosstalk with platelets. This interaction can come from the formation of platelet-leukocyte aggregates, signaling by direct contact between membrane surface molecules or by the stimulation of immune cells by soluble factors and active microparticles secreted by platelets. These ubiquitous blood components are able to sense and react to danger signals, guiding leukocytes to an injury site and providing a scaffold for the formation of extracellular traps for efficient microbial killing and clearance. Using several different mechanisms, platelets have an important task as they regulate the release of different cytokines and chemokines upon sterile or infectious damage, the expression of cell markers and regulation of cell death and survival. Therefore, platelets are more than clotting agents, but critical players within the fine inflammatory equilibrium for the host. In this review, we present pointers to a better understanding about how platelets control and modulate innate immune cells, as well as a summary of the outcome of this interaction, providing an important step for therapeutic opportunities and guidance for future research on infectious and autoimmune diseases.
KW  - Animals
KW  - Apoptosis: immunology
KW  - Blood Platelets: immunology
KW  - Cell Communication: immunology
KW  - Cell Movement: immunology
KW  - Cell Survival: immunology
KW  - Cytokines: biosynthesis
KW  - Extracellular Traps: immunology
KW  - Humans
KW  - Immunity, Innate
KW  - Infections: immunology
KW  - Inflammation: immunology
KW  - Leukocytes: immunology
KW  - Phagocytosis: immunology
KW  - Signal Transduction: immunology
KW  - cell survival (Other)
KW  - cytokine production (Other)
KW  - inflammation (Other)
KW  - innate immunity (Other)
KW  - leukocyte migration (Other)
KW  - platelets (Other)
KW  - Cytokines (NLM Chemicals)
LB  - PUB:(DE-HGF)16
DO  - DOI:10.3389/fimmu.2019.01320
UR  - https://pub.dzne.de/record/284087
ER  -