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@ARTICLE{SecchimRibeiro:284087,
      author       = {Secchim Ribeiro, Lucas and Migliari Branco, Laura and
                      Franklin, Bernardo S.},
      title        = {{R}egulation of {I}nnate {I}mmune {R}esponses by
                      {P}latelets},
      journal      = {Frontiers in immunology},
      volume       = {10},
      issn         = {1664-3224},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DZNE-2026-00095},
      pages        = {1320},
      year         = {2019},
      abstract     = {The role of platelets has been extensively studied in the
                      context of coagulation and vascular integrity. Their
                      hemostatic imbalance can lead to known conditions as
                      atherosclerotic plaques, thrombosis, and ischemia.
                      Nevertheless, the knowledge regarding the regulation of
                      different cell types by platelets has been growing
                      exponentially in the past years. Among these biological
                      systems, the innate immune response is remarkably affected
                      by the crosstalk with platelets. This interaction can come
                      from the formation of platelet-leukocyte aggregates,
                      signaling by direct contact between membrane surface
                      molecules or by the stimulation of immune cells by soluble
                      factors and active microparticles secreted by platelets.
                      These ubiquitous blood components are able to sense and
                      react to danger signals, guiding leukocytes to an injury
                      site and providing a scaffold for the formation of
                      extracellular traps for efficient microbial killing and
                      clearance. Using several different mechanisms, platelets
                      have an important task as they regulate the release of
                      different cytokines and chemokines upon sterile or
                      infectious damage, the expression of cell markers and
                      regulation of cell death and survival. Therefore, platelets
                      are more than clotting agents, but critical players within
                      the fine inflammatory equilibrium for the host. In this
                      review, we present pointers to a better understanding about
                      how platelets control and modulate innate immune cells, as
                      well as a summary of the outcome of this interaction,
                      providing an important step for therapeutic opportunities
                      and guidance for future research on infectious and
                      autoimmune diseases.},
      subtyp        = {Review Article},
      keywords     = {Animals / Apoptosis: immunology / Blood Platelets:
                      immunology / Cell Communication: immunology / Cell Movement:
                      immunology / Cell Survival: immunology / Cytokines:
                      biosynthesis / Extracellular Traps: immunology / Humans /
                      Immunity, Innate / Infections: immunology / Inflammation:
                      immunology / Leukocytes: immunology / Phagocytosis:
                      immunology / Signal Transduction: immunology / cell survival
                      (Other) / cytokine production (Other) / inflammation (Other)
                      / innate immunity (Other) / leukocyte migration (Other) /
                      platelets (Other) / Cytokines (NLM Chemicals)},
      ddc          = {610},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.3389/fimmu.2019.01320},
      url          = {https://pub.dzne.de/record/284087},
}