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000284089 0247_ $$2doi$$a10.3389/fcimb.2017.00419
000284089 037__ $$aDZNE-2026-00097
000284089 041__ $$aEnglish
000284089 082__ $$a610
000284089 1001_ $$aOliveira, Lorena V. N.$$b0
000284089 245__ $$aInfluenza A Virus as a Predisposing Factor for Cryptococcosis
000284089 260__ $$aLausanne$$bFrontiers Media$$c2017
000284089 3367_ $$2DRIVER$$aarticle
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000284089 520__ $$aInfluenza A virus (IAV) infects millions of people annually and predisposes to secondary bacterial infections. Inhalation of fungi within the Cryptococcus complex causes pulmonary disease with secondary meningo-encephalitis. Underlying pulmonary disease is a strong risk factor for development of C. gattii cryptococcosis though the effect of concurrent infection with IAV has not been studied. We developed an in vivo model of Influenza A H1N1 and C. gattii co-infection. Co-infection resulted in a major increase in morbidity and mortality, with severe lung damage and a high brain fungal burden when mice were infected in the acute phase of influenza multiplication. Furthermore, IAV alters the host response to C. gattii, leading to recruitment of significantly more neutrophils and macrophages into the lungs. Moreover, IAV induced the production of type 1 interferons (IFN-α4/β) and the levels of IFN-γ were significantly reduced, which can be associated with impairment of the immune response to Cryptococcus during co-infection. Phagocytosis, killing of cryptococci and production of reactive oxygen species (ROS) by IAV-infected macrophages were reduced, independent of previous IFN-γ stimulation, leading to increased proliferation of the fungus within macrophages. In conclusion, IAV infection is a predisposing factor for severe disease and adverse outcomes in mice co-infected with C. gattii.
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000284089 650_7 $$2Other$$aCryptococcosis
000284089 650_7 $$2Other$$aCryptococcus gattii
000284089 650_7 $$2Other$$aco-infection
000284089 650_7 $$2Other$$ainfluenza A H1N1
000284089 650_7 $$2Other$$arisk factor
000284089 650_7 $$2NLM Chemicals$$aChemokines
000284089 650_7 $$2NLM Chemicals$$aCytokines
000284089 650_7 $$2NLM Chemicals$$aIFNG protein, mouse
000284089 650_7 $$2NLM Chemicals$$aReactive Oxygen Species
000284089 650_7 $$014691-52-2$$2NLM Chemicals$$aPeroxynitrous Acid
000284089 650_7 $$031C4KY9ESH$$2NLM Chemicals$$aNitric Oxide
000284089 650_7 $$082115-62-6$$2NLM Chemicals$$aInterferon-gamma
000284089 650_7 $$0EC 1.11.1.7$$2NLM Chemicals$$aPeroxidase
000284089 650_7 $$0EC 3.2.1.52$$2NLM Chemicals$$aAcetylglucosaminidase
000284089 650_2 $$2MeSH$$aAcetylglucosaminidase: metabolism
000284089 650_2 $$2MeSH$$aAnimals
000284089 650_2 $$2MeSH$$aBehavior, Animal
000284089 650_2 $$2MeSH$$aBrain: microbiology
000284089 650_2 $$2MeSH$$aBrain: pathology
000284089 650_2 $$2MeSH$$aCausality
000284089 650_2 $$2MeSH$$aCell Proliferation
000284089 650_2 $$2MeSH$$aChemokines: metabolism
000284089 650_2 $$2MeSH$$aCoinfection: immunology
000284089 650_2 $$2MeSH$$aCoinfection: microbiology
000284089 650_2 $$2MeSH$$aCoinfection: mortality
000284089 650_2 $$2MeSH$$aCoinfection: virology
000284089 650_2 $$2MeSH$$aCryptococcosis: complications
000284089 650_2 $$2MeSH$$aCryptococcosis: immunology
000284089 650_2 $$2MeSH$$aCryptococcus gattii: immunology
000284089 650_2 $$2MeSH$$aCryptococcus gattii: pathogenicity
000284089 650_2 $$2MeSH$$aCryptococcus neoformans: immunology
000284089 650_2 $$2MeSH$$aCytokines: metabolism
000284089 650_2 $$2MeSH$$aDisease Models, Animal
000284089 650_2 $$2MeSH$$aDisease Susceptibility
000284089 650_2 $$2MeSH$$aDogs
000284089 650_2 $$2MeSH$$aFemale
000284089 650_2 $$2MeSH$$aHumans
000284089 650_2 $$2MeSH$$aInfluenza A Virus, H1N1 Subtype: immunology
000284089 650_2 $$2MeSH$$aInfluenza A Virus, H1N1 Subtype: pathogenicity
000284089 650_2 $$2MeSH$$aInterferon-gamma: metabolism
000284089 650_2 $$2MeSH$$aLung: enzymology
000284089 650_2 $$2MeSH$$aLung: pathology
000284089 650_2 $$2MeSH$$aLung: virology
000284089 650_2 $$2MeSH$$aMacrophages: metabolism
000284089 650_2 $$2MeSH$$aMacrophages: virology
000284089 650_2 $$2MeSH$$aMadin Darby Canine Kidney Cells
000284089 650_2 $$2MeSH$$aMice
000284089 650_2 $$2MeSH$$aMice, Inbred C57BL
000284089 650_2 $$2MeSH$$aNeutrophils
000284089 650_2 $$2MeSH$$aNitric Oxide: metabolism
000284089 650_2 $$2MeSH$$aOrthomyxoviridae Infections: complications
000284089 650_2 $$2MeSH$$aOrthomyxoviridae Infections: immunology
000284089 650_2 $$2MeSH$$aPeroxidase: metabolism
000284089 650_2 $$2MeSH$$aPeroxynitrous Acid: metabolism
000284089 650_2 $$2MeSH$$aPhagocytosis
000284089 650_2 $$2MeSH$$aReactive Oxygen Species: metabolism
000284089 650_2 $$2MeSH$$aSurvival Rate
000284089 7001_ $$aCosta, Marliete C.$$b1
000284089 7001_ $$aMagalhães, Thaís F. F.$$b2
000284089 7001_ $$aBastos, Rafael W.$$b3
000284089 7001_ $$0P:(DE-2719)9003461$$aCampi Santos, Patricia$$b4$$udzne
000284089 7001_ $$aCarneiro, Hellem C. S.$$b5
000284089 7001_ $$aRibeiro, Noelly Q.$$b6
000284089 7001_ $$aFerreira, Gabriella F.$$b7
000284089 7001_ $$0P:(DE-2719)9001782$$aSecchim Ribeiro, Lucas$$b8$$udzne
000284089 7001_ $$aGonçalves, Ana P. F.$$b9
000284089 7001_ $$aFagundes, Caio T.$$b10
000284089 7001_ $$aPascoal-Xavier, Marcelo A.$$b11
000284089 7001_ $$aDjordjevic, Julianne T.$$b12
000284089 7001_ $$aSorrell, Tania C.$$b13
000284089 7001_ $$aSouza, Daniele G.$$b14
000284089 7001_ $$aMachado, Alexandre M. V.$$b15
000284089 7001_ $$aSantos, Daniel A.$$b16
000284089 773__ $$0PERI:(DE-600)2619676-1$$a10.3389/fcimb.2017.00419$$gVol. 7, p. 419$$p419$$tFrontiers in Cellular and Infection Microbiology$$v7$$x2235-2988$$y2017
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