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@ARTICLE{Perucci:284091,
      author       = {Perucci, Luiza O. and Campi Santos, Patricia and Secchim
                      Ribeiro, Lucas and Souza, Danielle G. and Gomes, Karina B.
                      and Dusse, Luci M. S. and Sousa, Lirlândia P.},
      title        = {{L}ipoxin {A}4 {I}s {I}ncreased in the {P}lasma of
                      {P}reeclamptic {W}omen},
      journal      = {American journal of hypertension},
      volume       = {29},
      number       = {10},
      issn         = {0895-7061},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2026-00099},
      pages        = {1179 - 1185},
      year         = {2016},
      abstract     = {Excessive inflammation is involved in preeclampsia (PE)
                      pathogenesis. Lipoxin A4 (LXA4) is an eicosanoid that
                      counter-regulates inflammation. The main objective of this
                      study was to determine LXA4 plasma levels in PE women. The
                      correlations among LXA4 levels, ultrasensitive C-reactive
                      protein (us-CRP) levels, and clinical/laboratory parameters
                      of the studied participants were also investigated.LXA4
                      plasma levels were determined by ELISA in 23 nonpregnant, 26
                      normotensive pregnant, and 27 PE women (early PE (N = 10)
                      and late PE (N = 17)), according to gestational age (GA) at
                      clinical symptoms onset). The clinical/laboratory parameters
                      included in Spearman's correlation analysis were: systolic
                      and diastolic blood pressure (SBP and DBP, respectively),
                      lactate dehydrogenase (LDH) activity, platelet count,
                      proteinuria, and white blood cell count (WBC).LXA4 levels
                      were higher in PE women than in nonpregnant and normotensive
                      pregnant women, and similar between nonpregnant and
                      normotensive pregnant women. LXA4 plasma levels were higher
                      in early PE vs. normotensive pregnancy (GA < 34 weeks) and
                      in late PE vs. normotensive pregnancy (GA ≥ 34 weeks). No
                      significant differences were detected between early and late
                      PE. LXA4 levels were positively correlated with us-CRP
                      levels, SBP, DBP, and WBC. No significant correlation was
                      detected between LXA4 levels and the other laboratory
                      parameters.Chronic inflammation in PE, in spite of increased
                      levels of LXA4, points to a possible failure in this
                      regulatory pathway. Further studies are necessary to clarify
                      this issue and to evaluate the role of LXA4 and other
                      proresolving mediators of inflammation in the pathogenesis
                      of PE.},
      keywords     = {Adult / C-Reactive Protein: metabolism / Case-Control
                      Studies / Female / Humans / Lipoxins: blood / Pre-Eclampsia:
                      blood / Pre-Eclampsia: immunology / Pregnancy / Young Adult
                      / blood pressure (Other) / hypertension (Other) /
                      inflammation (Other) / lipoxin A4 (Other) / preeclampsia
                      (Other) / resolution. (Other) / Lipoxins (NLM Chemicals) /
                      lipoxin A4 (NLM Chemicals) / C-Reactive Protein (NLM
                      Chemicals)},
      ddc          = {610},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1093/ajh/hpw053},
      url          = {https://pub.dzne.de/record/284091},
}