| 001 | 284093 | ||
| 005 | 20260126112138.0 | ||
| 024 | 7 | _ | |a 10.1038/ijo.2015.204 |2 doi |
| 024 | 7 | _ | |a 0307-0565 |2 ISSN |
| 024 | 7 | _ | |a 1476-5497 |2 ISSN |
| 037 | _ | _ | |a DZNE-2026-00101 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Freire, R. H. |b 0 |
| 245 | _ | _ | |a Wheat gluten intake increases weight gain and adiposity associated with reduced thermogenesis and energy expenditure in an animal model of obesity |
| 260 | _ | _ | |a Avenel, NJ |c 2016 |b Nature Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1769422860_1868 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a ISSN 1476-5497 not unique: **2 hits**. |
| 520 | _ | _ | |a The association between gluten and body weight is inconsistent. Previously, we showed that a gluten-free diet reduces weight gain without changing food intake in mice fed high-fat diets. In the present study, we investigated the effects of gluten intake on fat metabolism, thermogenesis and energy expenditure in mice fed a standard or high-fat diet.Mice were fed four different experimental diets during 8 weeks: a control-standard diet (CD), a CD added with 4.5% of wheat gluten (CD-G), a high-fat diet (HFD) and a HFD added with 4.5% of wheat gluten (HFD-G). After 8 weeks, the mice received (99m)Tc-radiolabeled gluten orally to study gluten absorption and biodistribution or they underwent indirect calorimetry. After killing, subcutaneous and brown adipose tissues (SAT and BAT) were collected to assess thermogenesis-related protein expression. Lipid metabolism was studied in adipocyte cultures from the four groups.Despite having had the same energy intake, CD-G and HFD-G mice exhibited increased body weight and fat deposits compared with their respective controls. (99m)Tc-GLU or its peptides were detected in the blood, liver and visceral adipose tissue, suggesting that gluten can even reach extraintestinal organs. Uncoupling protein-1 expression was reduced in the BAT of HFD-G and in the SAT of CD-G and HFD-G mice. Indirect calorimetry showed lower oxygen volume consumption in CD-G and HFD-G groups compared with their controls. In HFD mice, daily energy expenditure was reduced with gluten intake. Gluten also reduced adiponectin, peroxisome proliferator-activated receptor (PPAR)-α and PPARγ and hormone-sensitive lipase in cultures of isolated adipocytes from HFD mice, whereas in the CD-G group, gluten intake increased interleukin-6 expression and tended to increase that of tumor necrosis factor.Wheat gluten promotes weight gain in animals on both HFD and CD, partly by reducing the thermogenic capacity of adipose tissues. |
| 536 | _ | _ | |a 899 - ohne Topic (POF4-899) |0 G:(DE-HGF)POF4-899 |c POF4-899 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, Journals: pub.dzne.de |
| 650 | _ | 7 | |a Glutens |0 8002-80-0 |2 NLM Chemicals |
| 650 | _ | 2 | |a Adipogenesis |2 MeSH |
| 650 | _ | 2 | |a Adiposity |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Disease Models, Animal |2 MeSH |
| 650 | _ | 2 | |a Energy Intake |2 MeSH |
| 650 | _ | 2 | |a Energy Metabolism: physiology |2 MeSH |
| 650 | _ | 2 | |a Feeding Behavior |2 MeSH |
| 650 | _ | 2 | |a Gene Expression Regulation |2 MeSH |
| 650 | _ | 2 | |a Glutens |2 MeSH |
| 650 | _ | 2 | |a Lipid Metabolism |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Obesity: metabolism |2 MeSH |
| 650 | _ | 2 | |a Thermogenesis |2 MeSH |
| 650 | _ | 2 | |a Weight Gain: physiology |2 MeSH |
| 700 | 1 | _ | |a Fernandes, L. R. |b 1 |
| 700 | 1 | _ | |a Silva, R. B. |b 2 |
| 700 | 1 | _ | |a Coelho, B. S. L. |b 3 |
| 700 | 1 | _ | |a de Araújo, L. P. T. |b 4 |
| 700 | 1 | _ | |a Secchim Ribeiro, Lucas |0 P:(DE-2719)9001782 |b 5 |u dzne |
| 700 | 1 | _ | |a Andrade, J. M. O. |b 6 |
| 700 | 1 | _ | |a Lima, P. M. A. |b 7 |
| 700 | 1 | _ | |a Araújo, R. S. |b 8 |
| 700 | 1 | _ | |a Santos, S. H. S. |b 9 |
| 700 | 1 | _ | |a Coimbra, C. C. |b 10 |
| 700 | 1 | _ | |a Cardoso, V. N. |b 11 |
| 700 | 1 | _ | |a Alvarez-Leite, J. I. |b 12 |
| 773 | _ | _ | |a 10.1038/ijo.2015.204 |g Vol. 40, no. 3, p. 479 - 486 |0 PERI:(DE-600)2101927-7 |n 3 |p 479 - 486 |t International journal of obesity |v 40 |y 2016 |x 0307-0565 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/284093/files/DZNE-2026-00101_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/284093/files/DZNE-2026-00101_Restricted.pdf?subformat=pdfa |x pdfa |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 5 |6 P:(DE-2719)9001782 |
| 913 | 1 | _ | |a DE-HGF |b Programmungebundene Forschung |l ohne Programm |1 G:(DE-HGF)POF4-890 |0 G:(DE-HGF)POF4-899 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-800 |4 G:(DE-HGF)POF |v ohne Topic |x 0 |
| 915 | _ | _ | |a DEAL Springer |0 StatID:(DE-HGF)3002 |2 StatID |d 2025-01-01 |w ger |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b INT J OBESITY : 2022 |d 2025-01-01 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2025-01-01 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2025-01-01 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2025-01-01 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2025-01-01 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2025-01-01 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2025-01-01 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2025-01-01 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2025-01-01 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2025-01-01 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2025-01-01 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2025-01-01 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2025-01-01 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2025-01-01 |
| 920 | _ | _ | |l yes |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a I:(DE-2719)1040260 |
| 980 | 1 | _ | |a EXTERN4VITA |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|
guest ::