TY  - JOUR
AU  - Matsui, Tamires C.
AU  - Coura, Giovanna M. E.
AU  - Melo, Ivo S. F.
AU  - Batista, Carla R. A.
AU  - Augusto, Paulo Sérgio A.
AU  - Godin, Adriana M.
AU  - Araújo, Débora P.
AU  - César, Isabela C.
AU  - Secchim Ribeiro, Lucas
AU  - Souza, Danielle G.
AU  - Klein, André
AU  - de Fátima, Ângelo
AU  - Machado, Renes R.
AU  - Coelho, Márcio M.
TI  - Nicorandil inhibits neutrophil recruitment in carrageenan-induced experimental pleurisy in mice
JO  - European journal of pharmacology
VL  - 769
SN  - 0014-2999
CY  - New York, NY [u.a.]
PB  - Elsevier
M1  - DZNE-2026-00102
SP  - 306 - 312
PY  - 2015
AB  - Nicorandil is a drug characterized by the coupling of a nitric oxide (NO) donor to nicotinamide. We have previously demonstrated that nicotinamide exhibits activity in different models of pain and inflammation. Now, we investigated the effects induced by per os (p.o.) administration of nicorandil (25, 50 or 100mg/Kg) on neutrophil recruitment in a carrageenan-induced model of pleurisy in mice. Effects induced by nicorandil (100mg/kg) were compared with those induced by equimolar doses of nicotinamide (58mg/kg) and N-(2-hydroxyethyl)-nicotinamide (NHN; 79mg/kg). We also investigated whether effects on the production of inflammatory mediators play a role in the activity of nicorandil. P.o. nicorandil, 0.5h before and 1h after the i.pl. injection of carrageenan, reduced neutrophil recruitment. However, equimolar doses of nicotinamide or NHN failed to induce such effect. Single treatment (previous or late) with nicorandil (100mg/Kg, p.o.) also reduced neutrophils recruitment, although to a lesser extent when compared to the double treatment. Nicorandil reduced the concentrations of interleukin-1β, CXCL-1 and prostaglandin E2 in the pleural exudate. Concluding, we demonstrated the activity of nicorandil in a model of pleurisy induced by carrageenan. This activity was characterized by reduction of the neutrophil accumulation and inhibition of production of inflammatory mediators. The effects induced by nicorandil on the leukocytes recruitment and production of inflammatory mediators contribute to a better understanding of its clinical benefits and indicate that these benefits may be due to its vasodilating and anti-inflammatory activities.
KW  - Animals
KW  - Anti-Inflammatory Agents: pharmacology
KW  - Carrageenan: adverse effects
KW  - Cytokines: biosynthesis
KW  - Eicosanoids: biosynthesis
KW  - Female
KW  - Leukocytes: drug effects
KW  - Leukocytes: immunology
KW  - Leukocytes: metabolism
KW  - Mice
KW  - Neutrophil Infiltration: drug effects
KW  - Nicorandil: pharmacology
KW  - Nicorandil: therapeutic use
KW  - Pleurisy: chemically induced
KW  - Pleurisy: drug therapy
KW  - Pleurisy: immunology
KW  - Pleurisy: metabolism
KW  - Cytokines (Other)
KW  - Inflammation (Other)
KW  - Neutrophils (Other)
KW  - Nicorandil (Other)
KW  - Nicotinamide (Other)
KW  - Prostaglandin E(2) (Other)
KW  - Anti-Inflammatory Agents (NLM Chemicals)
KW  - Cytokines (NLM Chemicals)
KW  - Eicosanoids (NLM Chemicals)
KW  - Nicorandil (NLM Chemicals)
KW  - Carrageenan (NLM Chemicals)
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1016/j.ejphar.2015.11.034
UR  - https://pub.dzne.de/record/284094
ER  -