% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Matsui:284094,
      author       = {Matsui, Tamires C. and Coura, Giovanna M. E. and Melo, Ivo
                      S. F. and Batista, Carla R. A. and Augusto, Paulo Sérgio A.
                      and Godin, Adriana M. and Araújo, Débora P. and César,
                      Isabela C. and Secchim Ribeiro, Lucas and Souza, Danielle G.
                      and Klein, André and de Fátima, Ângelo and Machado, Renes
                      R. and Coelho, Márcio M.},
      title        = {{N}icorandil inhibits neutrophil recruitment in
                      carrageenan-induced experimental pleurisy in mice},
      journal      = {European journal of pharmacology},
      volume       = {769},
      issn         = {0014-2999},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2026-00102},
      pages        = {306 - 312},
      year         = {2015},
      abstract     = {Nicorandil is a drug characterized by the coupling of a
                      nitric oxide (NO) donor to nicotinamide. We have previously
                      demonstrated that nicotinamide exhibits activity in
                      different models of pain and inflammation. Now, we
                      investigated the effects induced by per os (p.o.)
                      administration of nicorandil (25, 50 or 100mg/Kg) on
                      neutrophil recruitment in a carrageenan-induced model of
                      pleurisy in mice. Effects induced by nicorandil (100mg/kg)
                      were compared with those induced by equimolar doses of
                      nicotinamide (58mg/kg) and N-(2-hydroxyethyl)-nicotinamide
                      (NHN; 79mg/kg). We also investigated whether effects on the
                      production of inflammatory mediators play a role in the
                      activity of nicorandil. P.o. nicorandil, 0.5h before and 1h
                      after the i.pl. injection of carrageenan, reduced neutrophil
                      recruitment. However, equimolar doses of nicotinamide or NHN
                      failed to induce such effect. Single treatment (previous or
                      late) with nicorandil (100mg/Kg, p.o.) also reduced
                      neutrophils recruitment, although to a lesser extent when
                      compared to the double treatment. Nicorandil reduced the
                      concentrations of interleukin-1β, CXCL-1 and prostaglandin
                      E2 in the pleural exudate. Concluding, we demonstrated the
                      activity of nicorandil in a model of pleurisy induced by
                      carrageenan. This activity was characterized by reduction of
                      the neutrophil accumulation and inhibition of production of
                      inflammatory mediators. The effects induced by nicorandil on
                      the leukocytes recruitment and production of inflammatory
                      mediators contribute to a better understanding of its
                      clinical benefits and indicate that these benefits may be
                      due to its vasodilating and anti-inflammatory activities.},
      keywords     = {Animals / Anti-Inflammatory Agents: pharmacology /
                      Carrageenan: adverse effects / Cytokines: biosynthesis /
                      Eicosanoids: biosynthesis / Female / Leukocytes: drug
                      effects / Leukocytes: immunology / Leukocytes: metabolism /
                      Mice / Neutrophil Infiltration: drug effects / Nicorandil:
                      pharmacology / Nicorandil: therapeutic use / Pleurisy:
                      chemically induced / Pleurisy: drug therapy / Pleurisy:
                      immunology / Pleurisy: metabolism / Cytokines (Other) /
                      Inflammation (Other) / Neutrophils (Other) / Nicorandil
                      (Other) / Nicotinamide (Other) / Prostaglandin E(2) (Other)
                      / Anti-Inflammatory Agents (NLM Chemicals) / Cytokines (NLM
                      Chemicals) / Eicosanoids (NLM Chemicals) / Nicorandil (NLM
                      Chemicals) / Carrageenan (NLM Chemicals)},
      ddc          = {610},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.ejphar.2015.11.034},
      url          = {https://pub.dzne.de/record/284094},
}