TY  - JOUR
AU  - P. P. Vilela, Ana
AU  - R. G. R. Aguiar, Eric
AU  - V. Ferreira, Flavia
AU  - Secchim Ribeiro, Lucas
AU  - P. Olmo, Roenick
AU  - T. Marques, Joao
TI  - Small Non-Coding RNAs as Biomarkers
JO  - Recent patents on biomarkers
VL  - 2
IS  - 2
SN  - 2210-3090
CY  - Sharjah
PB  - Bentham Science Publishers
M1  - DZNE-2026-00106
SP  - 119 - 130
PY  - 2012
N1  - ISSN 2210-3090 not unique: **2 hits**.
AB  - RNA interference (RNAi) pathways utilize small non-coding RNAs (ncRNAs) to regulate diverse biological processes in eukaryotes. Different classes of small ncRNAs function through distinct RNAi pathways and the focus of this review will be on two of these: microRNAs (miRNAs) and small interfering RNAs (siRNAs). The siRNA pathway is triggered by viral infection and repetitive elements functioning as a defense system in eukaryotes. miRNAs, on the other hand, are encoded in the genome and regulate a myriad of biological processes such as embryonic development and tissue differentiation in plants and animals. These different small RNA pathways have great potential to be used as biomarkers of the biological processes they regulate. In this review, we describe the role RNAi pathways have in diverse pathological and physiological conditions and how the detection of specific small ncRNAs can be used as biomarkers for these conditions. We discuss other areas not yet explored for the use of small ncRNAs as biomarkers and review recent patents proposing to use small RNAs as biomarkers. These patents mainly include cases where changes in expression of miRNAs, individually or in groups, have been shown to correlate with disease or disease states, most commonly cancer.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.2174/2210309011202020119
UR  - https://pub.dzne.de/record/284098
ER  -