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@ARTICLE{PPVilela:284098,
      author       = {P. P. Vilela, Ana and R. G. R. Aguiar, Eric and V.
                      Ferreira, Flavia and Secchim Ribeiro, Lucas and P. Olmo,
                      Roenick and T. Marques, Joao},
      title        = {{S}mall {N}on-{C}oding {RNA}s as {B}iomarkers},
      journal      = {Recent patents on biomarkers},
      volume       = {2},
      number       = {2},
      issn         = {2210-3090},
      address      = {Sharjah},
      publisher    = {Bentham Science Publishers},
      reportid     = {DZNE-2026-00106},
      pages        = {119 - 130},
      year         = {2012},
      note         = {ISSN 2210-3090 not unique: **2 hits**.},
      abstract     = {RNA interference (RNAi) pathways utilize small non-coding
                      RNAs (ncRNAs) to regulate diverse biological processes in
                      eukaryotes. Different classes of small ncRNAs function
                      through distinct RNAi pathways and the focus of this review
                      will be on two of these: microRNAs (miRNAs) and small
                      interfering RNAs (siRNAs). The siRNA pathway is triggered by
                      viral infection and repetitive elements functioning as a
                      defense system in eukaryotes. miRNAs, on the other hand, are
                      encoded in the genome and regulate a myriad of biological
                      processes such as embryonic development and tissue
                      differentiation in plants and animals. These different small
                      RNA pathways have great potential to be used as biomarkers
                      of the biological processes they regulate. In this review,
                      we describe the role RNAi pathways have in diverse
                      pathological and physiological conditions and how the
                      detection of specific small ncRNAs can be used as biomarkers
                      for these conditions. We discuss other areas not yet
                      explored for the use of small ncRNAs as biomarkers and
                      review recent patents proposing to use small RNAs as
                      biomarkers. These patents mainly include cases where changes
                      in expression of miRNAs, individually or in groups, have
                      been shown to correlate with disease or disease states, most
                      commonly cancer.},
      ddc          = {610},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.2174/2210309011202020119},
      url          = {https://pub.dzne.de/record/284098},
}