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000284099 037__ $$aDZNE-2026-00107
000284099 041__ $$aEnglish
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000284099 1001_ $$aSegatto, Marcela$$b0
000284099 245__ $$aGenetic diversity of Leishmania infantum field populations from Brazil
000284099 260__ $$aRio de Janeiro$$bInst.$$c2012
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000284099 520__ $$aLeishmania infantum (syn. Leishmania chagasi) is the etiological agent of visceral leishmaniasis (VL) in Brazil. The epidemiology of VL is poorly understood. Therefore, a more detailed molecular characterization at an intraspecific level is certainly needed. Herein, three independent molecular methods, multilocus microsatellite typing (MLMT), random amplification of polymorphic DNA (RAPD) and simple sequence repeats-polymerase chain reaction (SSR-PCR), were used to evaluate the genetic diversity of 53 L. infantum isolates from five different endemic areas in Brazil. Population structures were inferred by distance-based and Bayesian-based approaches. Eighteen very similar genotypes were detected by MLMT, most of them differed in only one locus and no correlation was found between MLMT profiles, geographical origin or the estimated population structure. However, complex profiles composed of 182 bands obtained by both RAPD and SSR-PCR assays gave different results. Unweighted pair group method with arithmetic mean trees built from these data revealed a high degree of homogeneity within isolates of L. infantum. Interestingly, despite this genetic homogeneity, most of the isolates clustered according to their geographical origin.
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000284099 650_7 $$2NLM Chemicals$$aDNA, Protozoan
000284099 650_2 $$2MeSH$$aAnimals
000284099 650_2 $$2MeSH$$aBrazil
000284099 650_2 $$2MeSH$$aCluster Analysis
000284099 650_2 $$2MeSH$$aDNA, Protozoan: genetics
000284099 650_2 $$2MeSH$$aDogs
000284099 650_2 $$2MeSH$$aGenetic Variation: genetics
000284099 650_2 $$2MeSH$$aGenotype
000284099 650_2 $$2MeSH$$aHumans
000284099 650_2 $$2MeSH$$aLeishmania infantum: genetics
000284099 650_2 $$2MeSH$$aLeishmania infantum: isolation & purification
000284099 650_2 $$2MeSH$$aMicrosatellite Repeats
000284099 650_2 $$2MeSH$$aMolecular Typing
000284099 650_2 $$2MeSH$$aPolymerase Chain Reaction
000284099 650_2 $$2MeSH$$aRandom Amplified Polymorphic DNA Technique
000284099 7001_ $$0P:(DE-2719)9001782$$aSecchim Ribeiro, Lucas$$b1
000284099 7001_ $$aCosta, Dorcas Lamounier$$b2
000284099 7001_ $$aCosta, Carlos Henrique Nery$$b3
000284099 7001_ $$aOliveira, Márcia Rosa de$$b4
000284099 7001_ $$aCarvalho, Sílvio Fernando Guimarães$$b5
000284099 7001_ $$aMacedo, Andréa Mara$$b6
000284099 7001_ $$aValadares, Helder Magno Silva$$b7
000284099 7001_ $$aDietze, Reynaldo$$b8
000284099 7001_ $$aBrito, Cristiana Ferreira Alves de$$b9
000284099 7001_ $$aLemos, Elenice Moreira$$b10
000284099 773__ $$0PERI:(DE-600)2017165-1$$a10.1590/S0074-02762012000100006$$gVol. 107, no. 1, p. 39 - 47$$n1$$p39 - 47$$tMemórias do Instituto Oswaldo Cruz$$v107$$x0074-0276$$y2012
000284099 8564_ $$uhttps://pub.dzne.de/record/284099/files/%5B2012%2C%20Segatto%20M%5D%20Genetic%20diversity%20of%20Leishmania%20infantum%20field%20populations%20from%20Brazil.pdf$$yOpenAccess
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