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024 7 _ |a 10.1590/S0074-02762012000100006
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024 7 _ |a 1678-8060
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037 _ _ |a DZNE-2026-00107
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Segatto, Marcela
|b 0
245 _ _ |a Genetic diversity of Leishmania infantum field populations from Brazil
260 _ _ |a Rio de Janeiro
|c 2012
|b Inst.
336 7 _ |a article
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520 _ _ |a Leishmania infantum (syn. Leishmania chagasi) is the etiological agent of visceral leishmaniasis (VL) in Brazil. The epidemiology of VL is poorly understood. Therefore, a more detailed molecular characterization at an intraspecific level is certainly needed. Herein, three independent molecular methods, multilocus microsatellite typing (MLMT), random amplification of polymorphic DNA (RAPD) and simple sequence repeats-polymerase chain reaction (SSR-PCR), were used to evaluate the genetic diversity of 53 L. infantum isolates from five different endemic areas in Brazil. Population structures were inferred by distance-based and Bayesian-based approaches. Eighteen very similar genotypes were detected by MLMT, most of them differed in only one locus and no correlation was found between MLMT profiles, geographical origin or the estimated population structure. However, complex profiles composed of 182 bands obtained by both RAPD and SSR-PCR assays gave different results. Unweighted pair group method with arithmetic mean trees built from these data revealed a high degree of homogeneity within isolates of L. infantum. Interestingly, despite this genetic homogeneity, most of the isolates clustered according to their geographical origin.
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650 _ 7 |a DNA, Protozoan
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Brazil
|2 MeSH
650 _ 2 |a Cluster Analysis
|2 MeSH
650 _ 2 |a DNA, Protozoan: genetics
|2 MeSH
650 _ 2 |a Dogs
|2 MeSH
650 _ 2 |a Genetic Variation: genetics
|2 MeSH
650 _ 2 |a Genotype
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Leishmania infantum: genetics
|2 MeSH
650 _ 2 |a Leishmania infantum: isolation & purification
|2 MeSH
650 _ 2 |a Microsatellite Repeats
|2 MeSH
650 _ 2 |a Molecular Typing
|2 MeSH
650 _ 2 |a Polymerase Chain Reaction
|2 MeSH
650 _ 2 |a Random Amplified Polymorphic DNA Technique
|2 MeSH
700 1 _ |a Secchim Ribeiro, Lucas
|0 P:(DE-2719)9001782
|b 1
700 1 _ |a Costa, Dorcas Lamounier
|b 2
700 1 _ |a Costa, Carlos Henrique Nery
|b 3
700 1 _ |a Oliveira, Márcia Rosa de
|b 4
700 1 _ |a Carvalho, Sílvio Fernando Guimarães
|b 5
700 1 _ |a Macedo, Andréa Mara
|b 6
700 1 _ |a Valadares, Helder Magno Silva
|b 7
700 1 _ |a Dietze, Reynaldo
|b 8
700 1 _ |a Brito, Cristiana Ferreira Alves de
|b 9
700 1 _ |a Lemos, Elenice Moreira
|b 10
773 _ _ |a 10.1590/S0074-02762012000100006
|g Vol. 107, no. 1, p. 39 - 47
|0 PERI:(DE-600)2017165-1
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|p 39 - 47
|t Memórias do Instituto Oswaldo Cruz
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|y 2012
|x 0074-0276
856 4 _ |u https://pub.dzne.de/record/284099/files/%5B2012%2C%20Segatto%20M%5D%20Genetic%20diversity%20of%20Leishmania%20infantum%20field%20populations%20from%20Brazil.pdf
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