Abstracts

Cannabinoid is currently one of the most commonly used recreational drugs in the world with an approximate user of 22.2 million. As more and more states in the US are legalizing the use of cannabinoid, the rate of cannabinoid use is increasing specially in pregnant women. [...]

Fatal familial insomnia (FFI) is an autosomaldominant prion disease caused by a D178Nmutation in PRNP in combination with methio-nine at codon 129 in the mutated allele of thesame gene. The present study analyzes patho-logical and molecular features in 7 FFI casescarrying the mutation D178N and M homozy-gous at the codon 129 of PRNP. [...]

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Background:Human cerebral small vessel disease (CSVD, cerebral microangiopathy) is one of the leading causes of vascular dementia and ischemic stroke and is caused by degenerative small vessel wall chang-es. In spontaneously hype1tensive stroke-prone rats (SHRSP), a wen-established animal model of.SVD, we recently showed that cerebral microangiopathy develops in distinct histopathologicall teps initiated by intracapillary and -arteriolar erythrocyte accumulations. [...]

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Alzheimer's disease (AD), the most common neurodegenerative disease, is characterized by extracellular deposits of amyloid peptides (Aβ), within senile plaques, and intracellular aggregation of hyperphosphorylated Tau protein causing neurofibrillary tangles (NFTs). AD is also defined by an extensive neuronal loss and chronic neuroinflammation mediated by microglial cells and astrocytes surrounding the lesions. [...]

APOE4 is the strongest genetic risk factor for late-onset Alz-heimer’s disease. While APOE influences brain amyloid-β(Aβ) pathology via affecting Aβ aggregation and clearance,recent findings reveal an Aβ-independent role of APOE inregulating tau-mediated neurodegeneration. [...]

Background: White matter (WM) alterations are a commonfeature of Alzheimer Disease (AD), typically detected in vivowith diffusion tensor imaging (DTI). Blood-based neurofila-ment light (NfL) is an emerging biomarker for monitoringneurodegeneration. [...]

Introduction A disintegrin and metalloproteinase 15(ADAM15) is a member of the ADAM family of metallo-proteinases, which are functionally important enzymesinvolved in a wide variety of biological functions. A previ-ous study on Adam15-null mice demonstrated that malemice lacking ADAM15 developed accelerated age-relatedosteoarthritis (OA), suggesting that ADAM15 has chon-droprotective effects in OA. [...]