Contributions to a conference proceedings

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2023-01-04
14:55
[DZNE-2023-00111] Journal Article/Contribution to a conference proceedings
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Segregation of brain systems is associated with cognitive and eye movement performance in the general population
Alzheimer's Association International Conference 2022, Meeting location, Alzheimer's and dementia 18(S1), () [10.1002/alz.062365]
The human brain is a large-scale network, which contains multiple segregated and functionally specialized systems. The organization of brain systems has been reported to change in a dedifferentiated way with increasing age. [...]

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2023-01-04
14:53
[DZNE-2023-00110] Journal Article/Contribution to a conference proceedings
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DEMENTIA CAREGIVER SUPPORT PROGRAM IN VIETNAM: DEVELOPMENT, IMPLEMENTATION AND FIRST RESULTS
Alzheimer's Association International Conference 2022, Meeting location, Alzheimer's and dementia 18(S8), () [10.1002/alz.062110]
Previous studies on support programs including psychoeducation, care training, and counselling have shown to be beneficial for family dementia caregivers with the potential to reduce care giver burden. In this pre-post study, we aimed to assess the effects of a new support program to reduce caregivers’ burden.MethodsWe developed and conducted a 4-week support program (4 sessions, 1.5 hours each). [...]

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2023-01-04
14:51
[DZNE-2023-00109] Journal Article/Contribution to a conference proceedings
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Effectiveness of a digitally supported care management program for family and other informal dementia caregivers: baseline data from the GAIN randomized controlled trial
Alzheimer's Association International Conference 2022, Meeting location, Alzheimer's and dementia 18(S8), () [10.1002/alz.061719]
Almost two-thirds of people with dementia (PwD) living at home receive care from a family or other informal caregiver. For the caregiver this can result in a work load comparable or above a full-time employment position. [...]

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2023-01-04
12:18
[DZNE-2023-00108] Journal Article/Contribution to a conference proceedings
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Age‐related tau‐PET uptake and its downstream effects extend beyond the medial temporal lobe in cognitively normal older adults
Alzheimer's Association International Conference 2022, Meeting location, Alzheimer's and dementia 18(S1), () [10.1002/alz.067081]
Amyloid-beta (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial temporal lobe (MTL). However, there is evidence that age-related Aβ-independent tau pathology is present outside the MTL (Kaufman et al., Acta Neuropathol, 2018). [...]

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2023-01-04
12:15
[DZNE-2023-00107] Journal Article/Contribution to a conference proceedings
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The Impact of COVID‐19 on Family Dementia Caregivers in Vietnam ‐ Insights from A Memory Clinic in Ho Chi Minh City
Alzheimer's Association International Conference 2022, Meeting location, Alzheimer's and dementia 18(S8), () [10.1002/alz.060139]
The COVID-19 pandemic has unprecedented consequences on stress, isolation, and financial well-being for family caregivers of people with dementia globally. In Vietnam, soaring COVID-19 cases have led to widespread social distancing, isolation, and quarantine orders from the government. [...]

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2023-01-04
12:11
[DZNE-2023-00106] Journal Article/Contribution to a conference proceedings
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AD‐causing variants that affect PSEN1 transmembrane domains are associated with faster neurodegeneration and cognitive decline compared to those affecting cytoplasmic domains.
Alzheimer's Association International Conference 2022, Meeting location, Alzheimer's and dementia 18(S1), () [10.1002/alz.068221]
Rates of cognitive and biomarker change in Autosomal Dominant Alzheimer disease (ADAD) vary substantially across individuals. Prior cross-sectional work suggests that the location of the pathogenic variant within PSEN1, specifically whether the underlying variant affects transmembrane (TM) or cytoplasmic (CY) domains in PSEN1, may be a key determinant in these differential rates of progression. [...]

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2023-01-04
12:06
[DZNE-2023-00105] Journal Article/Contribution to a conference proceedings
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Design and implementation of the participatory German network for translational dementia care research (TaNDem) – A Qualitative Study on the Perspectives of Stakeholders and Healthcare Providers in Dementia Care Research
Alzheimer's Association International Conference 2022, Meeting location, Alzheimer's and dementia 18(S9), () [10.1002/alz.063086]
Currently, there is a lack of sustainable, translational structures in dementia care research that enable a nationally guided participatory interaction between research, care practice, and those affected by dementia. A close cooperation between research and care practice with a simultaneous inclusion of those affected by dementia is essential to translate scientific evidence into practice and address routine care needs in healthcare research. [...]

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2023-01-04
12:03
[DZNE-2023-00104] Journal Article/Contribution to a conference proceedings
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Identifying relevant psychosocial factors in the Care of People with Dementia: findings of a focus group study with informal caregivers and health professionals
Alzheimer's Association International Conference 2022, Meeting location, Alzheimer's and dementia 18(S8), () [10.1002/alz.060058]
Psychosocial factors offer promising possibilities for preventing dementia and slowing its progression. The extent to which psychosocial factors are taken into account in the treatment and care of people with dementia is not well known. [...]

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2023-01-04
12:00
[DZNE-2023-00103] Journal Article/Contribution to a conference proceedings
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User‐centered design to examine interaction of people with MCI or dementia with smartwatches: the SAMi intervention study framework
Alzheimer's Association International Conference 2022, Meeting location, Alzheimer's and dementia 18(S8), () [10.1002/alz.060553]
Assistive technologies show promising features to support people with cognitive impairment in daily life, e.g. mobile sensors for falls detection. [...]

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2023-01-04
11:51
[DZNE-2023-00102] Journal Article/Contribution to a conference proceedings
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Subcortical tau‐accumulation predicts neuronal dysfunction in the cortex based on functional connectivity in 4R‐tauopathies
Alzheimer's Association International Conference 2022, Meeting location, Alzheimer's and dementia 18(S1), () [10.1002/alz.067547]
4-repeat (4R) tauopathies are neurodegenerative diseases characterized by cerebral accumulation of 4R tau pathology. The most prominent 4R-tauopathies are progressive-supranuclear-palsy (PSP) and corticobasal-syndrome (CBS) characterized by tau accumulation in subcortical nuclei as well as cortical neuronal dysfunction, as shown by PET-assessed hypoperfusion and glucose hypometabolism. [...]

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